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Standard automated perimetry versus matrix frequency doubling technology perimetry in subjects with ocular hypertension and healthy control subjects.

Lamparter J, Aliyeva S, Schulze A, Berres M, Pfeiffer N, Hoffmann EM - PLoS ONE (2013)

Bottom Line: In OHT subjects, supero-temporal, supero-nasal and nasal sectors correlated significantly (r = 0.49, 0.62 and 0.38, p≤0.01, respectively).Poor agreement was found in the temporal, infero-temporal and infero-nasal disc sectors.This missing correlation might be related to early retinal nerve fiber layer damage in these regions of the disc, recognized by one of the visual field instruments.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University Medical Centre Mainz, Mainz, Germany.

ABSTRACT

Background: To evaluate the relationship and agreement between standard automated perimetry (SAP) and Matrix frequency doubling technology (Matrix-FDT) in subjects with ocular hypertension and healthy control subjects.

Methods: Forty-four eyes of 44 ocular hypertensive subjects and 29 eyes of 29 healthy age-matched control subjects were included in this prospective study. All participants underwent complete ophthalmic examination, including slit-lamp biomicroscopy, intraocular pressure measurement, pachymetry, and dilated fundus examination, and showed reliable visual field tests. One randomly selected eye of each participant was examined with SAP (Swedish Interactive Threshold Algorithm [SITA] Standard 24-2 test) and Matrix-FDT (24-2 threshold test), in random order. Correlations between global indices (MD, PSD), regions (2 hemifields, 4 quadrants, 6 sectors) and 52 single field positions were analyzed using Spearman's rank correlation coefficient.

Results: In both groups, mean deviation values of SAP and Matrix-FDT correlated significantly (OHT subjects: r = 0.47, p<0.005; healthy subjects: r = 0.68; p<0.001, respectively). Pattern standard deviation of SAP and Matrix-FDT showed no significant correlation in healthy subjects but correlated significantly in ocular hypertensive subjects (r = 0.45, p<0.005). In healthy subjects, a significant correlation between SAP and Matrix-FDT was shown in the supero-temporal and infero-temporal sectors of the disc (r = 0.40 and r = 0.38, p<0.05, respectively). In OHT subjects, supero-temporal, supero-nasal and nasal sectors correlated significantly (r = 0.49, 0.62 and 0.38, p≤0.01, respectively). The correlation pattern of individual visual field test locations appeared heterogeneous in both groups.

Conclusions: In both, ocular hypertensive and healthy subjects SAP and Matrix-FDT correlate well. In ocular hypertensive subjects, both techniques showed good correlation in the supero-temporal, supero-nasal, and nasal sectors of the disc. Poor agreement was found in the temporal, infero-temporal and infero-nasal disc sectors. This missing correlation might be related to early retinal nerve fiber layer damage in these regions of the disc, recognized by one of the visual field instruments.

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Related in: MedlinePlus

Structure-function map according to Garway-Heath et al.Visual field test points/sectors of the visual field can be related to sectors of the optic nerve head.
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pone-0057663-g004: Structure-function map according to Garway-Heath et al.Visual field test points/sectors of the visual field can be related to sectors of the optic nerve head.

Mentions: Garway-Heath et al. established an optic disc-visual field map which relates six sectors of the optic disc (supero-temporal, supero-nasal, nasal, infero-nasal, infero-temporal, and temporal) to corresponding sectors of the visual field (figure 4). [24] According to this map, the average of all test points belonging to one sector was evaluated in order to analyze the sectoral correlation between SAP and Matrix-FDT. Following the Garway-Heath map, it was chosen to name the sectors according to their location on the ONH, not according to their location in the visual field. For instance, the VF-temporal/ONH-nasal pair was given the name “nasal sector”. The supero-nasal disc sector corresponds to a peripheral, arcuate-shaped sector in the infero-temporal (5 field points) and the infero-nasal visual field (6 field points).


Standard automated perimetry versus matrix frequency doubling technology perimetry in subjects with ocular hypertension and healthy control subjects.

Lamparter J, Aliyeva S, Schulze A, Berres M, Pfeiffer N, Hoffmann EM - PLoS ONE (2013)

Structure-function map according to Garway-Heath et al.Visual field test points/sectors of the visual field can be related to sectors of the optic nerve head.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3585161&req=5

pone-0057663-g004: Structure-function map according to Garway-Heath et al.Visual field test points/sectors of the visual field can be related to sectors of the optic nerve head.
Mentions: Garway-Heath et al. established an optic disc-visual field map which relates six sectors of the optic disc (supero-temporal, supero-nasal, nasal, infero-nasal, infero-temporal, and temporal) to corresponding sectors of the visual field (figure 4). [24] According to this map, the average of all test points belonging to one sector was evaluated in order to analyze the sectoral correlation between SAP and Matrix-FDT. Following the Garway-Heath map, it was chosen to name the sectors according to their location on the ONH, not according to their location in the visual field. For instance, the VF-temporal/ONH-nasal pair was given the name “nasal sector”. The supero-nasal disc sector corresponds to a peripheral, arcuate-shaped sector in the infero-temporal (5 field points) and the infero-nasal visual field (6 field points).

Bottom Line: In OHT subjects, supero-temporal, supero-nasal and nasal sectors correlated significantly (r = 0.49, 0.62 and 0.38, p≤0.01, respectively).Poor agreement was found in the temporal, infero-temporal and infero-nasal disc sectors.This missing correlation might be related to early retinal nerve fiber layer damage in these regions of the disc, recognized by one of the visual field instruments.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University Medical Centre Mainz, Mainz, Germany.

ABSTRACT

Background: To evaluate the relationship and agreement between standard automated perimetry (SAP) and Matrix frequency doubling technology (Matrix-FDT) in subjects with ocular hypertension and healthy control subjects.

Methods: Forty-four eyes of 44 ocular hypertensive subjects and 29 eyes of 29 healthy age-matched control subjects were included in this prospective study. All participants underwent complete ophthalmic examination, including slit-lamp biomicroscopy, intraocular pressure measurement, pachymetry, and dilated fundus examination, and showed reliable visual field tests. One randomly selected eye of each participant was examined with SAP (Swedish Interactive Threshold Algorithm [SITA] Standard 24-2 test) and Matrix-FDT (24-2 threshold test), in random order. Correlations between global indices (MD, PSD), regions (2 hemifields, 4 quadrants, 6 sectors) and 52 single field positions were analyzed using Spearman's rank correlation coefficient.

Results: In both groups, mean deviation values of SAP and Matrix-FDT correlated significantly (OHT subjects: r = 0.47, p<0.005; healthy subjects: r = 0.68; p<0.001, respectively). Pattern standard deviation of SAP and Matrix-FDT showed no significant correlation in healthy subjects but correlated significantly in ocular hypertensive subjects (r = 0.45, p<0.005). In healthy subjects, a significant correlation between SAP and Matrix-FDT was shown in the supero-temporal and infero-temporal sectors of the disc (r = 0.40 and r = 0.38, p<0.05, respectively). In OHT subjects, supero-temporal, supero-nasal and nasal sectors correlated significantly (r = 0.49, 0.62 and 0.38, p≤0.01, respectively). The correlation pattern of individual visual field test locations appeared heterogeneous in both groups.

Conclusions: In both, ocular hypertensive and healthy subjects SAP and Matrix-FDT correlate well. In ocular hypertensive subjects, both techniques showed good correlation in the supero-temporal, supero-nasal, and nasal sectors of the disc. Poor agreement was found in the temporal, infero-temporal and infero-nasal disc sectors. This missing correlation might be related to early retinal nerve fiber layer damage in these regions of the disc, recognized by one of the visual field instruments.

Show MeSH
Related in: MedlinePlus