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Sertoliform cystadenoma: a rare benign tumour of the rete testis.

Bremmer F, Schweyer S, Behnes CL, Blech M, Radzun HJ - Diagn Pathol (2013)

Bottom Line: They appear in patients from 26 to 62 years of age.Under the assumption of a malignant testicular tumour an inguinal orchiectomy was performed.Alpha feto protein (AFP), human chorionic gonadotropin (ß-HCG) and placental alkaline phosphatase (PLAP) as well as synaptophysin, epithelial membrane antigene (EMA), and BCL-2 were not expressed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, University of Göttingen, Göttingen, Germany. felix.bremmer@med.uni-goettingen.de

ABSTRACT

Unlabelled: Sertoliform cystadenoma of the rete testis represents an uncommon benign tumour. They appear in patients from 26 to 62 years of age. We describe a case of a 66-year-old man with a tumour in the area of the epididymal head. The tumour markers were not increased. Under the assumption of a malignant testicular tumour an inguinal orchiectomy was performed. The cut surface of this tumour was of grey/white color and showed small cysts. The tumour consisted of two compartments. The epithelial like tumour cells showed a sertoliform growth pattern and cystic dilatations. In between the tumour cells repeatedly actin expressing sclerotic areas could be recognized as the second tumour component. Proliferative activity was not increased. Immunohistochemically the tumour cells were positiv for inhibin, S-100, and CD 99. Alpha feto protein (AFP), human chorionic gonadotropin (ß-HCG) and placental alkaline phosphatase (PLAP) as well as synaptophysin, epithelial membrane antigene (EMA), and BCL-2 were not expressed. As far as we know this is the sixth reported case of this tumour. Because of the benign nature of this tumour the correct diagnosis is important for the intra- and postoperative management. Here we present a case of this rare tumour and discuss potential differential diagnosis.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1956026143857335.

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Sertoliform cystadenoma of the rete testis: On ultrasound examination the tumour arises from the rete testis (white arrow) and shows solid and cystic areas (black arrows, A + B).
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Figure 1: Sertoliform cystadenoma of the rete testis: On ultrasound examination the tumour arises from the rete testis (white arrow) and shows solid and cystic areas (black arrows, A + B).

Mentions: A 66 year old man was presented in the urological clinic because of slightly increased blood level of prostatic specific antigen. The investigation of the prostate revealed a benign hyperplasia. Further urological examinations showed a mass of approximately 2 cm in diameter in the area of the epididymal head (Figure 1A+B). On ultrasound examination this mass proved to be cystic and irregularly bounded. The tumour markers alpha-fetoprotein (AFP) and human chorionic gonadotropin (ß-HCG) were not increased. Under the assumption of a malignant testicular tumour an inguinal orchiectomy was performed.


Sertoliform cystadenoma: a rare benign tumour of the rete testis.

Bremmer F, Schweyer S, Behnes CL, Blech M, Radzun HJ - Diagn Pathol (2013)

Sertoliform cystadenoma of the rete testis: On ultrasound examination the tumour arises from the rete testis (white arrow) and shows solid and cystic areas (black arrows, A + B).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3584937&req=5

Figure 1: Sertoliform cystadenoma of the rete testis: On ultrasound examination the tumour arises from the rete testis (white arrow) and shows solid and cystic areas (black arrows, A + B).
Mentions: A 66 year old man was presented in the urological clinic because of slightly increased blood level of prostatic specific antigen. The investigation of the prostate revealed a benign hyperplasia. Further urological examinations showed a mass of approximately 2 cm in diameter in the area of the epididymal head (Figure 1A+B). On ultrasound examination this mass proved to be cystic and irregularly bounded. The tumour markers alpha-fetoprotein (AFP) and human chorionic gonadotropin (ß-HCG) were not increased. Under the assumption of a malignant testicular tumour an inguinal orchiectomy was performed.

Bottom Line: They appear in patients from 26 to 62 years of age.Under the assumption of a malignant testicular tumour an inguinal orchiectomy was performed.Alpha feto protein (AFP), human chorionic gonadotropin (ß-HCG) and placental alkaline phosphatase (PLAP) as well as synaptophysin, epithelial membrane antigene (EMA), and BCL-2 were not expressed.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, University of Göttingen, Göttingen, Germany. felix.bremmer@med.uni-goettingen.de

ABSTRACT

Unlabelled: Sertoliform cystadenoma of the rete testis represents an uncommon benign tumour. They appear in patients from 26 to 62 years of age. We describe a case of a 66-year-old man with a tumour in the area of the epididymal head. The tumour markers were not increased. Under the assumption of a malignant testicular tumour an inguinal orchiectomy was performed. The cut surface of this tumour was of grey/white color and showed small cysts. The tumour consisted of two compartments. The epithelial like tumour cells showed a sertoliform growth pattern and cystic dilatations. In between the tumour cells repeatedly actin expressing sclerotic areas could be recognized as the second tumour component. Proliferative activity was not increased. Immunohistochemically the tumour cells were positiv for inhibin, S-100, and CD 99. Alpha feto protein (AFP), human chorionic gonadotropin (ß-HCG) and placental alkaline phosphatase (PLAP) as well as synaptophysin, epithelial membrane antigene (EMA), and BCL-2 were not expressed. As far as we know this is the sixth reported case of this tumour. Because of the benign nature of this tumour the correct diagnosis is important for the intra- and postoperative management. Here we present a case of this rare tumour and discuss potential differential diagnosis.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1956026143857335.

Show MeSH
Related in: MedlinePlus