Limits...
Short-term role of the dietary total antioxidant capacity in two hypocaloric regimes on obese with metabolic syndrome symptoms: the RESMENA randomized controlled trial.

Lopez-Legarrea P, de la Iglesia R, Abete I, Bondia-Pons I, Navas-Carretero S, Forga L, Martinez JA, Zulet MA - Nutr Metab (Lond) (2013)

Bottom Line: Dietary TAC was the component which showed the major influence on body weight (p = 0.034), body mass index (p = 0.026), waist circumference (p = 0.083) and fat mass (p = 0.015) reductions.Transaminases (ALT and AST) levels (p = 0.062 and p = 0.004, respectively) were associated with lower TAC values.RESMENA diet was as effective as AHA pattern for reducing MetS features.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea rd 1, Pamplona, 31008, Spain. jalfmtz@unav.es.

ABSTRACT

Background: Dietary strategies seem to be the most prescribed therapy in order to counteract obesity regarding not only calorie restriction, but also bioactive ingredients and the composition of the consumed foods. Dietary total antioxidant capacity (TAC) is gaining importance in order to assess the quality of the diet.

Methods: Ninety-six obese adults presenting metabolic syndrome (MetS) symptoms completed an 8-week intervention trial to evaluate the effects of a novel dietary program with changes in the nutrient distribution and meal frequency and to compare it with a dietary pattern based on the American Heart Association (AHA) guidelines.Anthropometric and biochemical parameters were assessed at baseline and at the endpoint of the study, in addition to 48-hours food dietary records.

Results: Both diets equally (p > 0.05) improved MetS manifestations. Dietary TAC was the component which showed the major influence on body weight (p = 0.034), body mass index (p = 0.026), waist circumference (p = 0.083) and fat mass (p = 0.015) reductions. Transaminases (ALT and AST) levels (p = 0.062 and p = 0.004, respectively) were associated with lower TAC values.

Conclusion: RESMENA diet was as effective as AHA pattern for reducing MetS features. Dietary TAC was the most contributing factor involved in body weight and obesity related markers reduction.

Trial registration: http://www.clinicaltrials.gov; NCT01087086.

No MeSH data available.


Related in: MedlinePlus

Changes on selected parameters categorized by low (<10.629 mmol day-1, n = 45) or high (>10.629 mmol day-1, n = 45) Total Antioxidant Capacity. BMI: Body Mass Index; ALT: Alanine aminotransferase; AST: Aspartate aminotranferase. p-values comparing the differences between low-TAC and high-TAC groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3584921&req=5

Figure 2: Changes on selected parameters categorized by low (<10.629 mmol day-1, n = 45) or high (>10.629 mmol day-1, n = 45) Total Antioxidant Capacity. BMI: Body Mass Index; ALT: Alanine aminotransferase; AST: Aspartate aminotranferase. p-values comparing the differences between low-TAC and high-TAC groups.

Mentions: Dietary TAC was the major influential factor, as body weight (p = 0.034), BMI (p = 0.026), fat mass (p = 0.015) and AST (p = 0.004) were significantly improved by this variable (Table 4). Dietary TAC also seemed to have a potential effect in ALT variations (p = 0.062). Concerning GI/GL, a trend towards an influence of insulin was found (Table 4). Since dietary TAC seemed to be the most influencing variable among the dietary analyzed elements, we categorized the sample considering the median value in: high- TAC (> 10.629 mmol day-1) or low- TAC (<10.629 mmol day-1) (Figure 2). As expected, the percentage of subjects from the RESMENA group (71%) included in the high-TAC group was significantly higher (p < 0.001) as compared with the Control group (29%). Body weight losses were marginally (p = 0.066) different when the subjects were categorized by the dietary TAC (Figure 2). Thus, the group with a higher dietary TAC showed a greater body weight reduction (−7.52 ± 0.64 kg) when compared with the low-TAC group (−6.35 ± 0.86 kg). Waist circumference decreased marginally towards significant differences between the two groups (p = 0.082) being greater in the high-TAC one (−7.77 ± 2.07 cm vs. -6.15 ± 0.31 cm). Fat mass was significantly reduced in both TAC groups and differences between them regarding densitometry fat mass kilograms (p = 0.026) were found. The low-TAC group significantly reduces ALT (p = 0.001) and AST (p = 0.002) transaminases levels, being statistically significant regarding the high-TAC group (p = 0.044 and p = 0.004, respectively) (Figure 2).


Short-term role of the dietary total antioxidant capacity in two hypocaloric regimes on obese with metabolic syndrome symptoms: the RESMENA randomized controlled trial.

Lopez-Legarrea P, de la Iglesia R, Abete I, Bondia-Pons I, Navas-Carretero S, Forga L, Martinez JA, Zulet MA - Nutr Metab (Lond) (2013)

Changes on selected parameters categorized by low (<10.629 mmol day-1, n = 45) or high (>10.629 mmol day-1, n = 45) Total Antioxidant Capacity. BMI: Body Mass Index; ALT: Alanine aminotransferase; AST: Aspartate aminotranferase. p-values comparing the differences between low-TAC and high-TAC groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3584921&req=5

Figure 2: Changes on selected parameters categorized by low (<10.629 mmol day-1, n = 45) or high (>10.629 mmol day-1, n = 45) Total Antioxidant Capacity. BMI: Body Mass Index; ALT: Alanine aminotransferase; AST: Aspartate aminotranferase. p-values comparing the differences between low-TAC and high-TAC groups.
Mentions: Dietary TAC was the major influential factor, as body weight (p = 0.034), BMI (p = 0.026), fat mass (p = 0.015) and AST (p = 0.004) were significantly improved by this variable (Table 4). Dietary TAC also seemed to have a potential effect in ALT variations (p = 0.062). Concerning GI/GL, a trend towards an influence of insulin was found (Table 4). Since dietary TAC seemed to be the most influencing variable among the dietary analyzed elements, we categorized the sample considering the median value in: high- TAC (> 10.629 mmol day-1) or low- TAC (<10.629 mmol day-1) (Figure 2). As expected, the percentage of subjects from the RESMENA group (71%) included in the high-TAC group was significantly higher (p < 0.001) as compared with the Control group (29%). Body weight losses were marginally (p = 0.066) different when the subjects were categorized by the dietary TAC (Figure 2). Thus, the group with a higher dietary TAC showed a greater body weight reduction (−7.52 ± 0.64 kg) when compared with the low-TAC group (−6.35 ± 0.86 kg). Waist circumference decreased marginally towards significant differences between the two groups (p = 0.082) being greater in the high-TAC one (−7.77 ± 2.07 cm vs. -6.15 ± 0.31 cm). Fat mass was significantly reduced in both TAC groups and differences between them regarding densitometry fat mass kilograms (p = 0.026) were found. The low-TAC group significantly reduces ALT (p = 0.001) and AST (p = 0.002) transaminases levels, being statistically significant regarding the high-TAC group (p = 0.044 and p = 0.004, respectively) (Figure 2).

Bottom Line: Dietary TAC was the component which showed the major influence on body weight (p = 0.034), body mass index (p = 0.026), waist circumference (p = 0.083) and fat mass (p = 0.015) reductions.Transaminases (ALT and AST) levels (p = 0.062 and p = 0.004, respectively) were associated with lower TAC values.RESMENA diet was as effective as AHA pattern for reducing MetS features.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea rd 1, Pamplona, 31008, Spain. jalfmtz@unav.es.

ABSTRACT

Background: Dietary strategies seem to be the most prescribed therapy in order to counteract obesity regarding not only calorie restriction, but also bioactive ingredients and the composition of the consumed foods. Dietary total antioxidant capacity (TAC) is gaining importance in order to assess the quality of the diet.

Methods: Ninety-six obese adults presenting metabolic syndrome (MetS) symptoms completed an 8-week intervention trial to evaluate the effects of a novel dietary program with changes in the nutrient distribution and meal frequency and to compare it with a dietary pattern based on the American Heart Association (AHA) guidelines.Anthropometric and biochemical parameters were assessed at baseline and at the endpoint of the study, in addition to 48-hours food dietary records.

Results: Both diets equally (p > 0.05) improved MetS manifestations. Dietary TAC was the component which showed the major influence on body weight (p = 0.034), body mass index (p = 0.026), waist circumference (p = 0.083) and fat mass (p = 0.015) reductions. Transaminases (ALT and AST) levels (p = 0.062 and p = 0.004, respectively) were associated with lower TAC values.

Conclusion: RESMENA diet was as effective as AHA pattern for reducing MetS features. Dietary TAC was the most contributing factor involved in body weight and obesity related markers reduction.

Trial registration: http://www.clinicaltrials.gov; NCT01087086.

No MeSH data available.


Related in: MedlinePlus