Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice.
Bottom Line: Right beneath was a mononuclear cell accumulation consisting of CD45- or CD3-positive lymphocytes and CD45/CD3-negative F4/80 faintly positive macrophages; some of the macrophages contained singular MWCNT in their cytoplasm.The lesions were devoid of epithelioid cell granuloma and fibrosis.These findings were in favor of the widely proposed mode of action of fiber carcinogenesis, that is, frustrated phagocytosis where the mesotheliomagenic microenvironment on the peritoneal surface is neither qualitatively altered by the density of the fibers per area nor by the formation of granulomas against agglomerates.
Affiliation: Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan.Show MeSH
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Mentions: An additional finding was the dissemination of singular fibers to systemic organs such as the liver, mesenteric lymph nodes, pulmohilar lymph nodes, choroid plexus of the brain, glomeruli of the kidney and lung alveoli (Fig. 5). Because the brain, including the choroid plexus, lacks afferent lymphatics,17,18 it is probable that the fibers were distributed systemically via the blood stream.
Affiliation: Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan.