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Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice.

Takagi A, Hirose A, Futakuchi M, Tsuda H, Kanno J - Cancer Sci. (2012)

Bottom Line: Right beneath was a mononuclear cell accumulation consisting of CD45- or CD3-positive lymphocytes and CD45/CD3-negative F4/80 faintly positive macrophages; some of the macrophages contained singular MWCNT in their cytoplasm.The lesions were devoid of epithelioid cell granuloma and fibrosis.These findings were in favor of the widely proposed mode of action of fiber carcinogenesis, that is, frustrated phagocytosis where the mesotheliomagenic microenvironment on the peritoneal surface is neither qualitatively altered by the density of the fibers per area nor by the formation of granulomas against agglomerates.

View Article: PubMed Central - PubMed

Affiliation: Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan.

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Systemic distribution of singular fibers. Single micrometer-sized multi-wall carbon nanotube fibers are found in the choroid plexus in (a) normal lighting and (b) polarized light (in a mouse from the high-dose group sampled on day 168), (c) lung as an agglomerate within macrophages (polarized light) or (d) as singular fibers (polarized light) and (e) a renal glomerulus (polarized light) (in a mouse from the high-dose group sampled on day 197). Fibers were also found in hepatic sinusoids and mesenteric lymph nodes (not shown).
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fig05: Systemic distribution of singular fibers. Single micrometer-sized multi-wall carbon nanotube fibers are found in the choroid plexus in (a) normal lighting and (b) polarized light (in a mouse from the high-dose group sampled on day 168), (c) lung as an agglomerate within macrophages (polarized light) or (d) as singular fibers (polarized light) and (e) a renal glomerulus (polarized light) (in a mouse from the high-dose group sampled on day 197). Fibers were also found in hepatic sinusoids and mesenteric lymph nodes (not shown).

Mentions: An additional finding was the dissemination of singular fibers to systemic organs such as the liver, mesenteric lymph nodes, pulmohilar lymph nodes, choroid plexus of the brain, glomeruli of the kidney and lung alveoli (Fig. 5). Because the brain, including the choroid plexus, lacks afferent lymphatics,17,18 it is probable that the fibers were distributed systemically via the blood stream.


Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice.

Takagi A, Hirose A, Futakuchi M, Tsuda H, Kanno J - Cancer Sci. (2012)

Systemic distribution of singular fibers. Single micrometer-sized multi-wall carbon nanotube fibers are found in the choroid plexus in (a) normal lighting and (b) polarized light (in a mouse from the high-dose group sampled on day 168), (c) lung as an agglomerate within macrophages (polarized light) or (d) as singular fibers (polarized light) and (e) a renal glomerulus (polarized light) (in a mouse from the high-dose group sampled on day 197). Fibers were also found in hepatic sinusoids and mesenteric lymph nodes (not shown).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569866&req=5

fig05: Systemic distribution of singular fibers. Single micrometer-sized multi-wall carbon nanotube fibers are found in the choroid plexus in (a) normal lighting and (b) polarized light (in a mouse from the high-dose group sampled on day 168), (c) lung as an agglomerate within macrophages (polarized light) or (d) as singular fibers (polarized light) and (e) a renal glomerulus (polarized light) (in a mouse from the high-dose group sampled on day 197). Fibers were also found in hepatic sinusoids and mesenteric lymph nodes (not shown).
Mentions: An additional finding was the dissemination of singular fibers to systemic organs such as the liver, mesenteric lymph nodes, pulmohilar lymph nodes, choroid plexus of the brain, glomeruli of the kidney and lung alveoli (Fig. 5). Because the brain, including the choroid plexus, lacks afferent lymphatics,17,18 it is probable that the fibers were distributed systemically via the blood stream.

Bottom Line: Right beneath was a mononuclear cell accumulation consisting of CD45- or CD3-positive lymphocytes and CD45/CD3-negative F4/80 faintly positive macrophages; some of the macrophages contained singular MWCNT in their cytoplasm.The lesions were devoid of epithelioid cell granuloma and fibrosis.These findings were in favor of the widely proposed mode of action of fiber carcinogenesis, that is, frustrated phagocytosis where the mesotheliomagenic microenvironment on the peritoneal surface is neither qualitatively altered by the density of the fibers per area nor by the formation of granulomas against agglomerates.

View Article: PubMed Central - PubMed

Affiliation: Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan.

Show MeSH
Related in: MedlinePlus