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In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study.

Eskenazi B, Chevrier J, Rauch SA, Kogut K, Harley KG, Johnson C, Trujillo C, Sjödin A, Bradman A - Environ. Health Perspect. (2012)

Bottom Line: Maternal prenatal PBDE concentrations were associated with impaired attention as measured by a continuous performance task at 5 years and maternal report at 5 and 7 years of age, with poorer fine motor coordination-particularly in the nondominant-at both age points, and with decrements in Verbal and Full-Scale IQ at 7 years.PBDE concentrations in children 7 years of age were significantly or marginally associated with concurrent teacher reports of attention problems and decrements in Processing Speed, Perceptual Reasoning, Verbal Comprehension, and Full-Scale IQ.This study, the largest to date, contributes to growing evidence suggesting that PBDEs have adverse impacts on child neurobehavioral development.

View Article: PubMed Central - PubMed

Affiliation: Center for Environmental Research and Children's Health, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA. eskenazi@berkeley.edu

ABSTRACT

Background: California children's exposures to polybrominated diphenyl ether flame retardants (PBDEs) are among the highest worldwide. PBDEs are known endocrine disruptors and neurotoxicants in animals.

Objective: Here we investigate the relation of in utero and child PBDE exposure to neurobehavioral development among participants in CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas), a California birth cohort.

Methods: We measured PBDEs in maternal prenatal and child serum samples and examined the association of PBDE concentrations with children's attention, motor functioning, and cognition at 5 (n = 310) and 7 years of age (n = 323).

Results: Maternal prenatal PBDE concentrations were associated with impaired attention as measured by a continuous performance task at 5 years and maternal report at 5 and 7 years of age, with poorer fine motor coordination-particularly in the nondominant-at both age points, and with decrements in Verbal and Full-Scale IQ at 7 years. PBDE concentrations in children 7 years of age were significantly or marginally associated with concurrent teacher reports of attention problems and decrements in Processing Speed, Perceptual Reasoning, Verbal Comprehension, and Full-Scale IQ. These associations were not altered by adjustment for birth weight, gestational age, or maternal thyroid hormone levels.

Conclusions: Both prenatal and childhood PBDE exposures were associated with poorer attention, fine motor coordination, and cognition in the CHAMACOS cohort of school-age children. This study, the largest to date, contributes to growing evidence suggesting that PBDEs have adverse impacts on child neurobehavioral development.

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Related in: MedlinePlus

The point estimate and 95% CI for each quartile (Q) of maternal ∑PBDE concentration for outcomes that showed overall associations and evidence of nonlinearity (at p < 0.1). The quartile ranges for maternal PBDEs were ≤ 14.4, 14.5–24.78, 24.8–41.97, and ≥ 42 ng/g lipid. Tests for trend come from models using PBDE quartile (1–4) as a continuous variable.
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f1: The point estimate and 95% CI for each quartile (Q) of maternal ∑PBDE concentration for outcomes that showed overall associations and evidence of nonlinearity (at p < 0.1). The quartile ranges for maternal PBDEs were ≤ 14.4, 14.5–24.78, 24.8–41.97, and ≥ 42 ng/g lipid. Tests for trend come from models using PBDE quartile (1–4) as a continuous variable.

Mentions: Attention. At child age 5 years, maternal prenatal ΣPBDE concentrations (for the 4 main congeners) were marginally associated (p < 0.10) with maternally reported CBCL scores above the 93rd percentile for attention problems [adjusted odds ratio (aOR) for a 10-fold increase in ΣPBDE = 4.6; 95%CI: 0.9, 24.5] [see Supplemental Material, Table S5 (http://dx.doi.org/10.1289/ehp.1205597)], and strongly associated with both errors of omission scores and ADHD Confidence Index scores on the K-CPT (Table 1). Quartile categorization suggested that both errors of omission and the ADHD Confidence Index were primarily elevated in children with mothers in the highest quartile of ΣPBDE exposure (> 42 ng/g) (Figure 1).


In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study.

Eskenazi B, Chevrier J, Rauch SA, Kogut K, Harley KG, Johnson C, Trujillo C, Sjödin A, Bradman A - Environ. Health Perspect. (2012)

The point estimate and 95% CI for each quartile (Q) of maternal ∑PBDE concentration for outcomes that showed overall associations and evidence of nonlinearity (at p < 0.1). The quartile ranges for maternal PBDEs were ≤ 14.4, 14.5–24.78, 24.8–41.97, and ≥ 42 ng/g lipid. Tests for trend come from models using PBDE quartile (1–4) as a continuous variable.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569691&req=5

f1: The point estimate and 95% CI for each quartile (Q) of maternal ∑PBDE concentration for outcomes that showed overall associations and evidence of nonlinearity (at p < 0.1). The quartile ranges for maternal PBDEs were ≤ 14.4, 14.5–24.78, 24.8–41.97, and ≥ 42 ng/g lipid. Tests for trend come from models using PBDE quartile (1–4) as a continuous variable.
Mentions: Attention. At child age 5 years, maternal prenatal ΣPBDE concentrations (for the 4 main congeners) were marginally associated (p < 0.10) with maternally reported CBCL scores above the 93rd percentile for attention problems [adjusted odds ratio (aOR) for a 10-fold increase in ΣPBDE = 4.6; 95%CI: 0.9, 24.5] [see Supplemental Material, Table S5 (http://dx.doi.org/10.1289/ehp.1205597)], and strongly associated with both errors of omission scores and ADHD Confidence Index scores on the K-CPT (Table 1). Quartile categorization suggested that both errors of omission and the ADHD Confidence Index were primarily elevated in children with mothers in the highest quartile of ΣPBDE exposure (> 42 ng/g) (Figure 1).

Bottom Line: Maternal prenatal PBDE concentrations were associated with impaired attention as measured by a continuous performance task at 5 years and maternal report at 5 and 7 years of age, with poorer fine motor coordination-particularly in the nondominant-at both age points, and with decrements in Verbal and Full-Scale IQ at 7 years.PBDE concentrations in children 7 years of age were significantly or marginally associated with concurrent teacher reports of attention problems and decrements in Processing Speed, Perceptual Reasoning, Verbal Comprehension, and Full-Scale IQ.This study, the largest to date, contributes to growing evidence suggesting that PBDEs have adverse impacts on child neurobehavioral development.

View Article: PubMed Central - PubMed

Affiliation: Center for Environmental Research and Children's Health, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA. eskenazi@berkeley.edu

ABSTRACT

Background: California children's exposures to polybrominated diphenyl ether flame retardants (PBDEs) are among the highest worldwide. PBDEs are known endocrine disruptors and neurotoxicants in animals.

Objective: Here we investigate the relation of in utero and child PBDE exposure to neurobehavioral development among participants in CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas), a California birth cohort.

Methods: We measured PBDEs in maternal prenatal and child serum samples and examined the association of PBDE concentrations with children's attention, motor functioning, and cognition at 5 (n = 310) and 7 years of age (n = 323).

Results: Maternal prenatal PBDE concentrations were associated with impaired attention as measured by a continuous performance task at 5 years and maternal report at 5 and 7 years of age, with poorer fine motor coordination-particularly in the nondominant-at both age points, and with decrements in Verbal and Full-Scale IQ at 7 years. PBDE concentrations in children 7 years of age were significantly or marginally associated with concurrent teacher reports of attention problems and decrements in Processing Speed, Perceptual Reasoning, Verbal Comprehension, and Full-Scale IQ. These associations were not altered by adjustment for birth weight, gestational age, or maternal thyroid hormone levels.

Conclusions: Both prenatal and childhood PBDE exposures were associated with poorer attention, fine motor coordination, and cognition in the CHAMACOS cohort of school-age children. This study, the largest to date, contributes to growing evidence suggesting that PBDEs have adverse impacts on child neurobehavioral development.

Show MeSH
Related in: MedlinePlus