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Persistent organic pollutants and type 2 diabetes: a prospective analysis in the nurses' health study and meta-analysis.

Wu H, Bertrand KA, Choi AL, Hu FB, Laden F, Grandjean P, Sun Q - Environ. Health Perspect. (2012)

Bottom Line: We used a fixed-effects model to summarize results.After multivariable adjustment, plasma HCB concentration was positively associated with incident T2D [pooled odds ratio (OR) 3.59 (95% CI: 1.49, 8.64, ptrend = 0.003) comparing extreme tertiles].Other POPs were not significantly associated with diabetes.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

ABSTRACT

Background: Prospective data regarding persistent organic pollutants (POPs) and risk of type 2 diabetes (T2D) are limited, and the results for individual POPs are not entirely consistent across studies.

Objectives: We prospectively examined plasma POP concentrations in relation to incident T2D and summarized existing evidence in a meta-analysis.

Methods: Plasma polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) concentrations were measured in 1,095 women who were free of diabetes at blood draw in 1989-1990 and participated in two case-control studies in the Nurses' Health Study. We identified 48 incident T2D cases through 30 June 2008. We conducted a literature search in PubMed and EMBASE through December 2011 to identify prospective studies on POPs in relation to diabetes. We used a fixed-effects model to summarize results.

Results: After multivariable adjustment, plasma HCB concentration was positively associated with incident T2D [pooled odds ratio (OR) 3.59 (95% CI: 1.49, 8.64, ptrend = 0.003) comparing extreme tertiles]. Other POPs were not significantly associated with diabetes. After pooling our results with those of six published prospective studies that included 842 diabetes cases in total, we found that HCB and total PCBs both were associated with diabetes: the pooled ORs were 2.00 (95% CI: 1.13, 3.53; I2 = 21.4%, pheterogeneity = 0.28) and 1.70 (95% CI: 1.28, 2.27; I2 = 16.3%, pheterogeneity = 0.30) for HCB and total PCBs, respectively.

Conclusions: These findings support an association between POP exposure and the risk of T2D.

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Related in: MedlinePlus

Pooled fixed-effects ORs (95% CIs) of incident diabetes comparing extreme categories (the highest vs. the lowest) of POP concentrations; p-values are pheterogeneity.
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f2: Pooled fixed-effects ORs (95% CIs) of incident diabetes comparing extreme categories (the highest vs. the lowest) of POP concentrations; p-values are pheterogeneity.

Mentions: When all data were pooled using a fixed-effects model, high concentrations of total PCBs and HCB were significantly associated with risk of diabetes, and the test for heterogeneity was not significant (Figure 2). The pooled ORs of diabetes comparing high versus low concentrations were 1.70 (95% CI: 1.28, 2.27; I2 = 16.3%, pheterogeneity = 0.30) for total PCBs and 2.00 (95% CI: 1.13, 3.53; I2 = 21.4%, pheterogeneity = 0.28) for HCB. Of note, estimates for HCB based on data from two previous studies (Lee et al. 2010, 2011) and the NHL and breast cancer studies in the NHS. Most other POPs of interest showed positive associations, although none of these associations achieved statistical significance. For example, the pooled ORs of diabetes for high versus low concentrations were 1.25 (95% CI: 0.94, 1.66; I2 = 36.8%, pheterogeneity = 0.16) for DDE, 1.20 (95% CI: 0.73, 1.96; I2 = 24.7%, pheterogeneity = 0.26) for PCB-118, and 1.36 (95% CI: 0.69, 2.68; I2 = 0.0%, pheterogeneity = 0.38) for PCB-138 (Figure 2). When we used a random-effects model to pool these data, we found similar results (data not shown).


Persistent organic pollutants and type 2 diabetes: a prospective analysis in the nurses' health study and meta-analysis.

Wu H, Bertrand KA, Choi AL, Hu FB, Laden F, Grandjean P, Sun Q - Environ. Health Perspect. (2012)

Pooled fixed-effects ORs (95% CIs) of incident diabetes comparing extreme categories (the highest vs. the lowest) of POP concentrations; p-values are pheterogeneity.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569682&req=5

f2: Pooled fixed-effects ORs (95% CIs) of incident diabetes comparing extreme categories (the highest vs. the lowest) of POP concentrations; p-values are pheterogeneity.
Mentions: When all data were pooled using a fixed-effects model, high concentrations of total PCBs and HCB were significantly associated with risk of diabetes, and the test for heterogeneity was not significant (Figure 2). The pooled ORs of diabetes comparing high versus low concentrations were 1.70 (95% CI: 1.28, 2.27; I2 = 16.3%, pheterogeneity = 0.30) for total PCBs and 2.00 (95% CI: 1.13, 3.53; I2 = 21.4%, pheterogeneity = 0.28) for HCB. Of note, estimates for HCB based on data from two previous studies (Lee et al. 2010, 2011) and the NHL and breast cancer studies in the NHS. Most other POPs of interest showed positive associations, although none of these associations achieved statistical significance. For example, the pooled ORs of diabetes for high versus low concentrations were 1.25 (95% CI: 0.94, 1.66; I2 = 36.8%, pheterogeneity = 0.16) for DDE, 1.20 (95% CI: 0.73, 1.96; I2 = 24.7%, pheterogeneity = 0.26) for PCB-118, and 1.36 (95% CI: 0.69, 2.68; I2 = 0.0%, pheterogeneity = 0.38) for PCB-138 (Figure 2). When we used a random-effects model to pool these data, we found similar results (data not shown).

Bottom Line: We used a fixed-effects model to summarize results.After multivariable adjustment, plasma HCB concentration was positively associated with incident T2D [pooled odds ratio (OR) 3.59 (95% CI: 1.49, 8.64, ptrend = 0.003) comparing extreme tertiles].Other POPs were not significantly associated with diabetes.

View Article: PubMed Central - PubMed

Affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

ABSTRACT

Background: Prospective data regarding persistent organic pollutants (POPs) and risk of type 2 diabetes (T2D) are limited, and the results for individual POPs are not entirely consistent across studies.

Objectives: We prospectively examined plasma POP concentrations in relation to incident T2D and summarized existing evidence in a meta-analysis.

Methods: Plasma polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) concentrations were measured in 1,095 women who were free of diabetes at blood draw in 1989-1990 and participated in two case-control studies in the Nurses' Health Study. We identified 48 incident T2D cases through 30 June 2008. We conducted a literature search in PubMed and EMBASE through December 2011 to identify prospective studies on POPs in relation to diabetes. We used a fixed-effects model to summarize results.

Results: After multivariable adjustment, plasma HCB concentration was positively associated with incident T2D [pooled odds ratio (OR) 3.59 (95% CI: 1.49, 8.64, ptrend = 0.003) comparing extreme tertiles]. Other POPs were not significantly associated with diabetes. After pooling our results with those of six published prospective studies that included 842 diabetes cases in total, we found that HCB and total PCBs both were associated with diabetes: the pooled ORs were 2.00 (95% CI: 1.13, 3.53; I2 = 21.4%, pheterogeneity = 0.28) and 1.70 (95% CI: 1.28, 2.27; I2 = 16.3%, pheterogeneity = 0.30) for HCB and total PCBs, respectively.

Conclusions: These findings support an association between POP exposure and the risk of T2D.

Show MeSH
Related in: MedlinePlus