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Prenatal p,p´-DDE exposure and neurodevelopment among children 3.5-5 years of age.

Torres-Sánchez L, Schnaas L, Rothenberg SJ, Cebrián ME, Osorio-Valencia E, Hernández Mdel C, García-Hernández RM, López-Carrillo L - Environ. Health Perspect. (2012)

Bottom Line: After adjustment, a doubling of DDE during the third trimester of pregnancy was associated with statistically significant reductions of -1.37, -0.88, -0.84, and -0.80 points in the general cognitive index, quantitative, verbal, and memory components respectively.The association between prenatal DDE and the quantitative component was weaker at 42 months than at older ages.No significant statistical interactions with sex or breastfeeding were observed.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Public Health, Morelos, Mexico.

ABSTRACT

Background: The results of previous studies suggest that prenatal exposure to bis[p-chlorophenyl]-1,1,1-trichloroethane (DDT) and to its main metabolite, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), impairs psychomotor development during the first year of life. However, information about the persistence of this association at later ages is limited.

Objectives: We assessed the association of prenatal DDE exposure with child neurodevelopment at 42-60 months of age.

Methods: Since 2001 we have been monitoring the neurodevelopment in children who were recruited at birth into a perinatal cohort exposed to DDT, in the state of Morelos, Mexico. We report McCarthy Scales of Children's Abilities for 203 children at 42, 48, 54, and 60 months of age. Maternal DDE serum levels were available for at least one trimester of pregnancy. The Home Observation for Measurement of the Environment scale and other covariables of interest were also available.

Results: After adjustment, a doubling of DDE during the third trimester of pregnancy was associated with statistically significant reductions of -1.37, -0.88, -0.84, and -0.80 points in the general cognitive index, quantitative, verbal, and memory components respectively. The association between prenatal DDE and the quantitative component was weaker at 42 months than at older ages. No significant statistical interactions with sex or breastfeeding were observed.

Conclusions: These findings support the hypothesis that prenatal DDE impairs early child neurodevelopment; the potential for adverse effects on development should be considered when using DDT for malaria control.

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Related in: MedlinePlus

Maternal serum DDE during the third trimester and McCarthy Scales of Children’s Ability components according to age at evaluation. Interactions between serum DDE (continuous) and age at examination for each McCarthy component estimated through mixed-effects multivariate models. All models were adjusted for child’s age at examination, mother’s education and marital status when child was 4 years old, and HOME score. Additionally, the GCI model was adjusted by sex of child and attendance at a child care center; the quantitative model also was adjusted by maternal IQ and child’s birth weight; the verbal model also was adjusted by maternal age and IQ, birth weight, infant height at the time of the evaluation, and attendance at a child care center; the memory model also included maternal age and IQ, birth weight, and attendance at a child care center.
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f2: Maternal serum DDE during the third trimester and McCarthy Scales of Children’s Ability components according to age at evaluation. Interactions between serum DDE (continuous) and age at examination for each McCarthy component estimated through mixed-effects multivariate models. All models were adjusted for child’s age at examination, mother’s education and marital status when child was 4 years old, and HOME score. Additionally, the GCI model was adjusted by sex of child and attendance at a child care center; the quantitative model also was adjusted by maternal IQ and child’s birth weight; the verbal model also was adjusted by maternal age and IQ, birth weight, infant height at the time of the evaluation, and attendance at a child care center; the memory model also included maternal age and IQ, birth weight, and attendance at a child care center.

Mentions: The association between maternal serum DDE during the third trimester and the quantitative component score varied depending on age at assessment, with a statistically significant interaction at 54 months, compared to 42 months, resulting in a weaker association at 42 months (Figure 2). No significant interactions between other components and age (Figure 2), or between any components and sex or breastfeeding (data not shown), were observed (interaction p-values > 0.10). The HOME scale was a statistically significant positive predictor of all McCarthy test components (data not shown).


Prenatal p,p´-DDE exposure and neurodevelopment among children 3.5-5 years of age.

Torres-Sánchez L, Schnaas L, Rothenberg SJ, Cebrián ME, Osorio-Valencia E, Hernández Mdel C, García-Hernández RM, López-Carrillo L - Environ. Health Perspect. (2012)

Maternal serum DDE during the third trimester and McCarthy Scales of Children’s Ability components according to age at evaluation. Interactions between serum DDE (continuous) and age at examination for each McCarthy component estimated through mixed-effects multivariate models. All models were adjusted for child’s age at examination, mother’s education and marital status when child was 4 years old, and HOME score. Additionally, the GCI model was adjusted by sex of child and attendance at a child care center; the quantitative model also was adjusted by maternal IQ and child’s birth weight; the verbal model also was adjusted by maternal age and IQ, birth weight, infant height at the time of the evaluation, and attendance at a child care center; the memory model also included maternal age and IQ, birth weight, and attendance at a child care center.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569679&req=5

f2: Maternal serum DDE during the third trimester and McCarthy Scales of Children’s Ability components according to age at evaluation. Interactions between serum DDE (continuous) and age at examination for each McCarthy component estimated through mixed-effects multivariate models. All models were adjusted for child’s age at examination, mother’s education and marital status when child was 4 years old, and HOME score. Additionally, the GCI model was adjusted by sex of child and attendance at a child care center; the quantitative model also was adjusted by maternal IQ and child’s birth weight; the verbal model also was adjusted by maternal age and IQ, birth weight, infant height at the time of the evaluation, and attendance at a child care center; the memory model also included maternal age and IQ, birth weight, and attendance at a child care center.
Mentions: The association between maternal serum DDE during the third trimester and the quantitative component score varied depending on age at assessment, with a statistically significant interaction at 54 months, compared to 42 months, resulting in a weaker association at 42 months (Figure 2). No significant interactions between other components and age (Figure 2), or between any components and sex or breastfeeding (data not shown), were observed (interaction p-values > 0.10). The HOME scale was a statistically significant positive predictor of all McCarthy test components (data not shown).

Bottom Line: After adjustment, a doubling of DDE during the third trimester of pregnancy was associated with statistically significant reductions of -1.37, -0.88, -0.84, and -0.80 points in the general cognitive index, quantitative, verbal, and memory components respectively.The association between prenatal DDE and the quantitative component was weaker at 42 months than at older ages.No significant statistical interactions with sex or breastfeeding were observed.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Public Health, Morelos, Mexico.

ABSTRACT

Background: The results of previous studies suggest that prenatal exposure to bis[p-chlorophenyl]-1,1,1-trichloroethane (DDT) and to its main metabolite, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), impairs psychomotor development during the first year of life. However, information about the persistence of this association at later ages is limited.

Objectives: We assessed the association of prenatal DDE exposure with child neurodevelopment at 42-60 months of age.

Methods: Since 2001 we have been monitoring the neurodevelopment in children who were recruited at birth into a perinatal cohort exposed to DDT, in the state of Morelos, Mexico. We report McCarthy Scales of Children's Abilities for 203 children at 42, 48, 54, and 60 months of age. Maternal DDE serum levels were available for at least one trimester of pregnancy. The Home Observation for Measurement of the Environment scale and other covariables of interest were also available.

Results: After adjustment, a doubling of DDE during the third trimester of pregnancy was associated with statistically significant reductions of -1.37, -0.88, -0.84, and -0.80 points in the general cognitive index, quantitative, verbal, and memory components respectively. The association between prenatal DDE and the quantitative component was weaker at 42 months than at older ages. No significant statistical interactions with sex or breastfeeding were observed.

Conclusions: These findings support the hypothesis that prenatal DDE impairs early child neurodevelopment; the potential for adverse effects on development should be considered when using DDT for malaria control.

Show MeSH
Related in: MedlinePlus