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Prenatal p,p´-DDE exposure and neurodevelopment among children 3.5-5 years of age.

Torres-Sánchez L, Schnaas L, Rothenberg SJ, Cebrián ME, Osorio-Valencia E, Hernández Mdel C, García-Hernández RM, López-Carrillo L - Environ. Health Perspect. (2012)

Bottom Line: After adjustment, a doubling of DDE during the third trimester of pregnancy was associated with statistically significant reductions of -1.37, -0.88, -0.84, and -0.80 points in the general cognitive index, quantitative, verbal, and memory components respectively.The association between prenatal DDE and the quantitative component was weaker at 42 months than at older ages.No significant statistical interactions with sex or breastfeeding were observed.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Public Health, Morelos, Mexico.

ABSTRACT

Background: The results of previous studies suggest that prenatal exposure to bis[p-chlorophenyl]-1,1,1-trichloroethane (DDT) and to its main metabolite, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), impairs psychomotor development during the first year of life. However, information about the persistence of this association at later ages is limited.

Objectives: We assessed the association of prenatal DDE exposure with child neurodevelopment at 42-60 months of age.

Methods: Since 2001 we have been monitoring the neurodevelopment in children who were recruited at birth into a perinatal cohort exposed to DDT, in the state of Morelos, Mexico. We report McCarthy Scales of Children's Abilities for 203 children at 42, 48, 54, and 60 months of age. Maternal DDE serum levels were available for at least one trimester of pregnancy. The Home Observation for Measurement of the Environment scale and other covariables of interest were also available.

Results: After adjustment, a doubling of DDE during the third trimester of pregnancy was associated with statistically significant reductions of -1.37, -0.88, -0.84, and -0.80 points in the general cognitive index, quantitative, verbal, and memory components respectively. The association between prenatal DDE and the quantitative component was weaker at 42 months than at older ages. No significant statistical interactions with sex or breastfeeding were observed.

Conclusions: These findings support the hypothesis that prenatal DDE impairs early child neurodevelopment; the potential for adverse effects on development should be considered when using DDT for malaria control.

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Related in: MedlinePlus

Morelos Perinatal Cohort Study 2001–2009.
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f1: Morelos Perinatal Cohort Study 2001–2009.

Mentions: During 8.5 years of follow-up, 442 live first births occurred among the women (80% were primiparous) who had enrolled before their pregnancy (Figure 1). Eligibility criteria for this analysis were at least two assessments in the child for neurodevelopment between 42 and 60 months of age, birth weight of ≥ 2 kg, no history of complicated birth, and available maternal DDE serum levels for at least one trimester of pregnancy. There were 203 eligible children. Characteristics of 124 children who were lost to follow-up before 42 months of age and of 77 children who were excluded (noneligible) are shown in Table 1. The main reasons for loss to follow-up were change of address and lack of parental interest.


Prenatal p,p´-DDE exposure and neurodevelopment among children 3.5-5 years of age.

Torres-Sánchez L, Schnaas L, Rothenberg SJ, Cebrián ME, Osorio-Valencia E, Hernández Mdel C, García-Hernández RM, López-Carrillo L - Environ. Health Perspect. (2012)

Morelos Perinatal Cohort Study 2001–2009.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569679&req=5

f1: Morelos Perinatal Cohort Study 2001–2009.
Mentions: During 8.5 years of follow-up, 442 live first births occurred among the women (80% were primiparous) who had enrolled before their pregnancy (Figure 1). Eligibility criteria for this analysis were at least two assessments in the child for neurodevelopment between 42 and 60 months of age, birth weight of ≥ 2 kg, no history of complicated birth, and available maternal DDE serum levels for at least one trimester of pregnancy. There were 203 eligible children. Characteristics of 124 children who were lost to follow-up before 42 months of age and of 77 children who were excluded (noneligible) are shown in Table 1. The main reasons for loss to follow-up were change of address and lack of parental interest.

Bottom Line: After adjustment, a doubling of DDE during the third trimester of pregnancy was associated with statistically significant reductions of -1.37, -0.88, -0.84, and -0.80 points in the general cognitive index, quantitative, verbal, and memory components respectively.The association between prenatal DDE and the quantitative component was weaker at 42 months than at older ages.No significant statistical interactions with sex or breastfeeding were observed.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Public Health, Morelos, Mexico.

ABSTRACT

Background: The results of previous studies suggest that prenatal exposure to bis[p-chlorophenyl]-1,1,1-trichloroethane (DDT) and to its main metabolite, 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), impairs psychomotor development during the first year of life. However, information about the persistence of this association at later ages is limited.

Objectives: We assessed the association of prenatal DDE exposure with child neurodevelopment at 42-60 months of age.

Methods: Since 2001 we have been monitoring the neurodevelopment in children who were recruited at birth into a perinatal cohort exposed to DDT, in the state of Morelos, Mexico. We report McCarthy Scales of Children's Abilities for 203 children at 42, 48, 54, and 60 months of age. Maternal DDE serum levels were available for at least one trimester of pregnancy. The Home Observation for Measurement of the Environment scale and other covariables of interest were also available.

Results: After adjustment, a doubling of DDE during the third trimester of pregnancy was associated with statistically significant reductions of -1.37, -0.88, -0.84, and -0.80 points in the general cognitive index, quantitative, verbal, and memory components respectively. The association between prenatal DDE and the quantitative component was weaker at 42 months than at older ages. No significant statistical interactions with sex or breastfeeding were observed.

Conclusions: These findings support the hypothesis that prenatal DDE impairs early child neurodevelopment; the potential for adverse effects on development should be considered when using DDT for malaria control.

Show MeSH
Related in: MedlinePlus