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Imaging of multifocal liver lesions in children and adolescents.

Hegde SV, Dillman JR, Lopez MJ, Strouse PJ - Cancer Imaging (2013)

Bottom Line: Multifocal liver lesions are encountered regularly in children and adolescents.By knowing the specific ultrasonographic, computed tomographic, and magnetic resonance imaging (MRI) features of benign and malignant pediatric liver lesions as well as the particular clinical setting, radiologists can frequently narrow the differential diagnosis and sometimes offer a definitive diagnosis.The purpose of this review article is to illustrate the imaging findings of numerous benign and malignant causes of multifocal liver lesions in the pediatric population.

View Article: PubMed Central - PubMed

Affiliation: Section of Pediatric Radiology, Department of Radiology, University of Michigan Health System, Ann Arbor, MI, USA.

ABSTRACT
Multifocal liver lesions are encountered regularly in children and adolescents. By knowing the specific ultrasonographic, computed tomographic, and magnetic resonance imaging (MRI) features of benign and malignant pediatric liver lesions as well as the particular clinical setting, radiologists can frequently narrow the differential diagnosis and sometimes offer a definitive diagnosis. The purpose of this review article is to illustrate the imaging findings of numerous benign and malignant causes of multifocal liver lesions in the pediatric population.

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A 19-year-old woman with progressive abdominal distention due to fibrolamellar hepatocellular carcinoma. (a,b) Coronal reformatted postcontrast CT images show a large, circumscribed, lobular hyperenhancing mass (arrows) within the right hepatic lobe that contains central calcification. The liver is markedly enlarged, and scattered arterially hyperenhancing satellite lesions are present throughout the liver (arrowheads).
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Figure 11: A 19-year-old woman with progressive abdominal distention due to fibrolamellar hepatocellular carcinoma. (a,b) Coronal reformatted postcontrast CT images show a large, circumscribed, lobular hyperenhancing mass (arrows) within the right hepatic lobe that contains central calcification. The liver is markedly enlarged, and scattered arterially hyperenhancing satellite lesions are present throughout the liver (arrowheads).

Mentions: Fibrolamellar HCCs are generally large, circumscribed, lobulated masses that arterially hyperenhance on CT and MRI, and may contain central calcification and scarring (Fig. 11)[25]. Satellite lesions are present in 10–15% of cases (Fig. 11)[17]. The central scar associated with fibrolamellar HCC is typically hypointense on T2-weighted MRI, unlike that seen with FNH[17,25]. These tumors are often at an advanced stage at the time of diagnosis, and lymph node metastases are common[26,27].Figure 11


Imaging of multifocal liver lesions in children and adolescents.

Hegde SV, Dillman JR, Lopez MJ, Strouse PJ - Cancer Imaging (2013)

A 19-year-old woman with progressive abdominal distention due to fibrolamellar hepatocellular carcinoma. (a,b) Coronal reformatted postcontrast CT images show a large, circumscribed, lobular hyperenhancing mass (arrows) within the right hepatic lobe that contains central calcification. The liver is markedly enlarged, and scattered arterially hyperenhancing satellite lesions are present throughout the liver (arrowheads).
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Related In: Results  -  Collection

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Figure 11: A 19-year-old woman with progressive abdominal distention due to fibrolamellar hepatocellular carcinoma. (a,b) Coronal reformatted postcontrast CT images show a large, circumscribed, lobular hyperenhancing mass (arrows) within the right hepatic lobe that contains central calcification. The liver is markedly enlarged, and scattered arterially hyperenhancing satellite lesions are present throughout the liver (arrowheads).
Mentions: Fibrolamellar HCCs are generally large, circumscribed, lobulated masses that arterially hyperenhance on CT and MRI, and may contain central calcification and scarring (Fig. 11)[25]. Satellite lesions are present in 10–15% of cases (Fig. 11)[17]. The central scar associated with fibrolamellar HCC is typically hypointense on T2-weighted MRI, unlike that seen with FNH[17,25]. These tumors are often at an advanced stage at the time of diagnosis, and lymph node metastases are common[26,27].Figure 11

Bottom Line: Multifocal liver lesions are encountered regularly in children and adolescents.By knowing the specific ultrasonographic, computed tomographic, and magnetic resonance imaging (MRI) features of benign and malignant pediatric liver lesions as well as the particular clinical setting, radiologists can frequently narrow the differential diagnosis and sometimes offer a definitive diagnosis.The purpose of this review article is to illustrate the imaging findings of numerous benign and malignant causes of multifocal liver lesions in the pediatric population.

View Article: PubMed Central - PubMed

Affiliation: Section of Pediatric Radiology, Department of Radiology, University of Michigan Health System, Ann Arbor, MI, USA.

ABSTRACT
Multifocal liver lesions are encountered regularly in children and adolescents. By knowing the specific ultrasonographic, computed tomographic, and magnetic resonance imaging (MRI) features of benign and malignant pediatric liver lesions as well as the particular clinical setting, radiologists can frequently narrow the differential diagnosis and sometimes offer a definitive diagnosis. The purpose of this review article is to illustrate the imaging findings of numerous benign and malignant causes of multifocal liver lesions in the pediatric population.

Show MeSH
Related in: MedlinePlus