Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival.
Bottom Line: The mRNA levels of FoxP3, TGF-β, IL4 and Gata3, a Th2 transcription factor, were reduced in rapidly progressing patients and inversely correlated with progression rates.No differences in IL10, Tbx21, a Th1 transcription factor or IFN-γ expression were found between slow and rapidly progressing patients.Importantly, early reduced FoxP3 levels could be used to identify rapidly progressing patients.
Affiliation: Department of Neurology, The Methodist Hospital Research Institute, Houston, TX, USA. firstname.lastname@example.orgShow MeSH
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Mentions: As Th2 lymphocytes are also neuroprotective in the ALS mouse (Beers et al, 2011b), we addressed whether Gata3, the master transcription factor for Th2 lymphocytes (Zhu & Paul, 2010) might also be affected. Gata3 levels in rapidly progressing patients were reduced 47% compared with slowly progressing patients (p = 0.003) and 57% compared with control volunteers (p = 0.00001; Fig 4A). Gata3 levels in ALS patients' leukocytes were inversely correlated with disease progression rates (p = 0.004; Fig 4B). Gata3 levels also directly correlated with FoxP3 and CD25 levels (both p < 0.001; Fig 4C and D).
Affiliation: Department of Neurology, The Methodist Hospital Research Institute, Houston, TX, USA. email@example.com