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MicroRNAs in age-related diseases.

Dimmeler S, Nicotera P - EMBO Mol Med (2013)

Bottom Line: MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs.MiRNAs target up to hundreds of mRNAs, thereby modulating gene expression patterns.The present article will discuss these findings, specifically focusing on the cardiovascular and neurological systems.

View Article: PubMed Central - PubMed

Affiliation: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany. dimmeler@em.uni-frankfurt.de

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Regulation of miRNAs during cardiovascular agingThe impact of aging on the vasculature and the heart is summarized. MiRNAs that are regulated during aging of the vasculature or the heart are shown with arrows indicating up- or downregulation during aging in comparison to young tissue. Only validated targets are shown.
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fig01: Regulation of miRNAs during cardiovascular agingThe impact of aging on the vasculature and the heart is summarized. MiRNAs that are regulated during aging of the vasculature or the heart are shown with arrows indicating up- or downregulation during aging in comparison to young tissue. Only validated targets are shown.

Mentions: Aging is the predominant risk factor for developing cardiovascular diseases (North & Sinclair, 2012). In the vasculature, aging impairs the atheroprotective effects of the endothelium as evidenced by reduced nitric oxide bioavailability and increased NFkB activation leading to endothelial inflammation (Pierce et al, 2009). Additionally, the smooth muscle cell phenotype is changed towards a pro-proliferative and pro-invasive characteristic and the composition of the extracellular matrix is significantly modulated (Wang et al, 2010a). Together, these changes result in arterial remodelling characterized by thickening of the intima and reduced arterial dilation capacity (Fig 1). It is considered that the changes in cellular functions and extracellular matrix during aging make the atrial wall susceptible for atherosclerotic lesion progression.


MicroRNAs in age-related diseases.

Dimmeler S, Nicotera P - EMBO Mol Med (2013)

Regulation of miRNAs during cardiovascular agingThe impact of aging on the vasculature and the heart is summarized. MiRNAs that are regulated during aging of the vasculature or the heart are shown with arrows indicating up- or downregulation during aging in comparison to young tissue. Only validated targets are shown.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569636&req=5

fig01: Regulation of miRNAs during cardiovascular agingThe impact of aging on the vasculature and the heart is summarized. MiRNAs that are regulated during aging of the vasculature or the heart are shown with arrows indicating up- or downregulation during aging in comparison to young tissue. Only validated targets are shown.
Mentions: Aging is the predominant risk factor for developing cardiovascular diseases (North & Sinclair, 2012). In the vasculature, aging impairs the atheroprotective effects of the endothelium as evidenced by reduced nitric oxide bioavailability and increased NFkB activation leading to endothelial inflammation (Pierce et al, 2009). Additionally, the smooth muscle cell phenotype is changed towards a pro-proliferative and pro-invasive characteristic and the composition of the extracellular matrix is significantly modulated (Wang et al, 2010a). Together, these changes result in arterial remodelling characterized by thickening of the intima and reduced arterial dilation capacity (Fig 1). It is considered that the changes in cellular functions and extracellular matrix during aging make the atrial wall susceptible for atherosclerotic lesion progression.

Bottom Line: MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs.MiRNAs target up to hundreds of mRNAs, thereby modulating gene expression patterns.The present article will discuss these findings, specifically focusing on the cardiovascular and neurological systems.

View Article: PubMed Central - PubMed

Affiliation: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany. dimmeler@em.uni-frankfurt.de

Show MeSH
Related in: MedlinePlus