MicroRNAs in age-related diseases.
Bottom Line: MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs.MiRNAs target up to hundreds of mRNAs, thereby modulating gene expression patterns.The present article will discuss these findings, specifically focusing on the cardiovascular and neurological systems.
Affiliation: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Aging is the predominant risk factor for developing cardiovascular diseases (North & Sinclair, 2012). In the vasculature, aging impairs the atheroprotective effects of the endothelium as evidenced by reduced nitric oxide bioavailability and increased NFkB activation leading to endothelial inflammation (Pierce et al, 2009). Additionally, the smooth muscle cell phenotype is changed towards a pro-proliferative and pro-invasive characteristic and the composition of the extracellular matrix is significantly modulated (Wang et al, 2010a). Together, these changes result in arterial remodelling characterized by thickening of the intima and reduced arterial dilation capacity (Fig 1). It is considered that the changes in cellular functions and extracellular matrix during aging make the atrial wall susceptible for atherosclerotic lesion progression.
Affiliation: Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, Frankfurt, Germany. firstname.lastname@example.org