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The use of electrospray mass spectrometry to determine speciation in a dynamic combinatorial library for anion recognition.

Phillips HI, Chernikov AV, Fletcher NC, Ashcroft AE, Ault JR, Filby MH, Wilson AJ - Chemistry (2012)

Bottom Line: The time taken for the complexes to come to equilibrium appears to be dependent on the counteranion, with chloride causing a rapid redistribution of two preformed heteroleptic complexes (of the order of 1 hour), whereas the time it takes in the presence of tetrafluoroborate salts is in excess of 24 h.Similarly the final distribution of products is dependent on the anion present, with the presence of chloride, and to a lesser extent bromide, preferring three amide-functionalized ligands, and a slight preference for an appended benzyl over a methoxyethyl group.Furthermore, for the first time, this study shows that the distribution of a dynamic library of metal complexes monitored by ESI-MS can adapt following the introduction of a different anion, in this case tetrabutylammonium chloride to give the most favoured heteroleptic complex despite the increasing ionic strength of the solution.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry and Chemical Engineering, Queen's University Belfast, UK.

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The equilibrium identified within a combination of [Fe(L1)3]Cl2 and [Fe(L3)3]Cl2 in acetonitrile.
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sch01: The equilibrium identified within a combination of [Fe(L1)3]Cl2 and [Fe(L3)3]Cl2 in acetonitrile.


The use of electrospray mass spectrometry to determine speciation in a dynamic combinatorial library for anion recognition.

Phillips HI, Chernikov AV, Fletcher NC, Ashcroft AE, Ault JR, Filby MH, Wilson AJ - Chemistry (2012)

The equilibrium identified within a combination of [Fe(L1)3]Cl2 and [Fe(L3)3]Cl2 in acetonitrile.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569615&req=5

sch01: The equilibrium identified within a combination of [Fe(L1)3]Cl2 and [Fe(L3)3]Cl2 in acetonitrile.
Bottom Line: The time taken for the complexes to come to equilibrium appears to be dependent on the counteranion, with chloride causing a rapid redistribution of two preformed heteroleptic complexes (of the order of 1 hour), whereas the time it takes in the presence of tetrafluoroborate salts is in excess of 24 h.Similarly the final distribution of products is dependent on the anion present, with the presence of chloride, and to a lesser extent bromide, preferring three amide-functionalized ligands, and a slight preference for an appended benzyl over a methoxyethyl group.Furthermore, for the first time, this study shows that the distribution of a dynamic library of metal complexes monitored by ESI-MS can adapt following the introduction of a different anion, in this case tetrabutylammonium chloride to give the most favoured heteroleptic complex despite the increasing ionic strength of the solution.

View Article: PubMed Central - PubMed

Affiliation: School of Chemistry and Chemical Engineering, Queen's University Belfast, UK.

Show MeSH