Final follow-up of the Multicentre Aneurysm Screening Study (MASS) randomized trial of abdominal aortic aneurysm screening.
Bottom Line: There was no evidence of effect on other causes of death, but there was an overall reduction in all-cause mortality of 3 (1 to 5) per cent.The degree of benefit seen in earlier years of follow-up was slightly diminished by the occurrence of AAA ruptures in those with an aorta originally screened normal.Screening resulted in a reduction in all-cause mortality, and the benefit in AAA-related mortality continued to accumulate throughout follow-up.
Affiliation: Department of Public Health and Primary Care, University of Cambridge, UK. email@example.comShow MeSH
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Mentions: There were 224 AAA-related deaths (absolute risk 0·66 per cent) in the invited group compared with 381 (1·12 per cent) in the control group, a relative risk reduction of 42 per cent (hazard ratio 0·58, 95 per cent c.i. 0·49 to 0·69) (Table2). There was no evidence that the relative risk reduction varied by baseline age or centre (tests for interaction P = 0·586 and P = 0·531 respectively). The number of men needed to be invited to screening to save one death over 13 years was estimated as 216. The AAA mortality curves in the two groups continued to diverge throughout follow-up (Fig.1). However, there was a slight reduction in the benefit seen after 10 years; from randomization to 10 years the risk reduction was 48 per cent, whereas during years 10–13 it was 20 per cent.
Affiliation: Department of Public Health and Primary Care, University of Cambridge, UK. firstname.lastname@example.org