Limits...
Low postnatal serum IGF-I levels are associated with bronchopulmonary dysplasia (BPD).

Löfqvist C, Hellgren G, Niklasson A, Engström E, Ley D, Hansen-Pupp I, WINROP Consorti - Acta Paediatr. (2012)

Bottom Line: Postnatal mean IGF-I levels at postnatal day (PND) 3-21 were lower in infants with BPD compared with infants with no BPD (16 vs. 26 μg/L, p < 0.001).In a binomial multiple regression model, lower GA, male gender and lower mean serum IGF-I levels during PND 3-21 were the most predictive risk factors associated with BPD (r(2) = 0.634, p < 0.001).Lower IGF-I concentrations during the first weeks after very preterm birth are associated with later development of BPD.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. chatarina.lofqvist@gu.se

Show MeSH

Related in: MedlinePlus

Mean serum IGF-I μg/L (95% CI) values for postnatal day (PND) 3–21 days (top) and PMA 30-33 weeks(bottom) in infants with and without bronchopulmonary dysplasia, ***p < 0.001.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3569611&req=5

fig01: Mean serum IGF-I μg/L (95% CI) values for postnatal day (PND) 3–21 days (top) and PMA 30-33 weeks(bottom) in infants with and without bronchopulmonary dysplasia, ***p < 0.001.

Mentions: To evaluate postnatal serum IGF-I concentration after birth, both mean IGF-I levels during postnatal day (PND) 3–21 and mean IGF-I levels during postmenstrual week 30–33 were calculated. Mean (SD) IGF-I levels PND 3–21 days were lower in infants with BPD compared with infants with no BPD (16 (5.80) vs. 26 (10.09) μg/L, p < 0.001). Further, the mean (SD) IGF-I levels at PMA 30-33 weeks were lower in infants with BPD than in those without BPD [23 (7.5) μg/L vs. 31 (9.6) μg/L, p < 0.001]. These differences remained significant after adjusting for GA (Fig. 1).


Low postnatal serum IGF-I levels are associated with bronchopulmonary dysplasia (BPD).

Löfqvist C, Hellgren G, Niklasson A, Engström E, Ley D, Hansen-Pupp I, WINROP Consorti - Acta Paediatr. (2012)

Mean serum IGF-I μg/L (95% CI) values for postnatal day (PND) 3–21 days (top) and PMA 30-33 weeks(bottom) in infants with and without bronchopulmonary dysplasia, ***p < 0.001.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569611&req=5

fig01: Mean serum IGF-I μg/L (95% CI) values for postnatal day (PND) 3–21 days (top) and PMA 30-33 weeks(bottom) in infants with and without bronchopulmonary dysplasia, ***p < 0.001.
Mentions: To evaluate postnatal serum IGF-I concentration after birth, both mean IGF-I levels during postnatal day (PND) 3–21 and mean IGF-I levels during postmenstrual week 30–33 were calculated. Mean (SD) IGF-I levels PND 3–21 days were lower in infants with BPD compared with infants with no BPD (16 (5.80) vs. 26 (10.09) μg/L, p < 0.001). Further, the mean (SD) IGF-I levels at PMA 30-33 weeks were lower in infants with BPD than in those without BPD [23 (7.5) μg/L vs. 31 (9.6) μg/L, p < 0.001]. These differences remained significant after adjusting for GA (Fig. 1).

Bottom Line: Postnatal mean IGF-I levels at postnatal day (PND) 3-21 were lower in infants with BPD compared with infants with no BPD (16 vs. 26 μg/L, p < 0.001).In a binomial multiple regression model, lower GA, male gender and lower mean serum IGF-I levels during PND 3-21 were the most predictive risk factors associated with BPD (r(2) = 0.634, p < 0.001).Lower IGF-I concentrations during the first weeks after very preterm birth are associated with later development of BPD.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. chatarina.lofqvist@gu.se

Show MeSH
Related in: MedlinePlus