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Quantum combinatorial model of gene expression.

Grover M, Grover R, Singh R, Kumar R, Kumar S - Bioinformation (2013)

Bottom Line: We propose that the DNA within the chromatin behaves as a dynamic combinatorial library capable of forming novel structures by reversible processes.RNA polymerase then could scan these states and the system decoheres to the "appropriate" state.Two ways of sustaining quantum coherence at relevant time scales could be possible, first, screening: the quantum system can be kept isolated from its decohering environment, second, the existence of decoherence free subspaces .We discuss the role of superconductivity in context of avoiding decoherence in context of our hypothesis.

View Article: PubMed Central - PubMed

Affiliation: National Bureau of Plant Genetic Resources, Pusa Campus, New Delhi, India ; Amity Institute of Biotechnology, Amity University, NOIDA, India.

ABSTRACT
We propose that the DNA within the chromatin behaves as a dynamic combinatorial library capable of forming novel structures by reversible processes. We also hypothesize that states within the library may be linked via quantum tunneling. RNA polymerase then could scan these states and the system decoheres to the "appropriate" state. Two ways of sustaining quantum coherence at relevant time scales could be possible, first, screening: the quantum system can be kept isolated from its decohering environment, second, the existence of decoherence free subspaces .We discuss the role of superconductivity in context of avoiding decoherence in context of our hypothesis.

No MeSH data available.


Keto and Enol forms of nucleotides
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Related In: Results  -  Collection


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Figure 1: Keto and Enol forms of nucleotides

Mentions: Quantum tunneling is a term widely used in chemistry and isalso termed as chemical tautomerization. Several compoundssuch as nucleotide bases exist as mixtures of related chemicalstructures known as tautomers. In context of nucleic acidstautomeric structures differ with respect to the position ofprotons with in nucleotides thus resulting in keto and enolforms. The alternative positions of keto and enol forms arelinked by proton tunneling [2] and each preparation ofnucleotides contains a mixture of tautomers. Each molecule of aDNA base exists as superposition of enol or keto form (Figure 1) linked by proton tunneling, the composition of the mixturebeing governed by relative stability of each tautomer. It isnoteworthy that there are several molecules in the DNA thatexist in such superposition. We propose that the DNA moleculeexists in a superposition of all the possible tautomeric states, thesearch of the DNA space results in selection of most appropriateconfiguration of DNA for the given environmentalcondition/developmental stage. It is however critical that thequantum superposition of all possible states in thecombinatorial library can be built up and scanned before theonset of decoherence. This is also the principle that forms thebasis of a quantum computer. That is why quantumcomputation is so fast.


Quantum combinatorial model of gene expression.

Grover M, Grover R, Singh R, Kumar R, Kumar S - Bioinformation (2013)

Keto and Enol forms of nucleotides
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3569601&req=5

Figure 1: Keto and Enol forms of nucleotides
Mentions: Quantum tunneling is a term widely used in chemistry and isalso termed as chemical tautomerization. Several compoundssuch as nucleotide bases exist as mixtures of related chemicalstructures known as tautomers. In context of nucleic acidstautomeric structures differ with respect to the position ofprotons with in nucleotides thus resulting in keto and enolforms. The alternative positions of keto and enol forms arelinked by proton tunneling [2] and each preparation ofnucleotides contains a mixture of tautomers. Each molecule of aDNA base exists as superposition of enol or keto form (Figure 1) linked by proton tunneling, the composition of the mixturebeing governed by relative stability of each tautomer. It isnoteworthy that there are several molecules in the DNA thatexist in such superposition. We propose that the DNA moleculeexists in a superposition of all the possible tautomeric states, thesearch of the DNA space results in selection of most appropriateconfiguration of DNA for the given environmentalcondition/developmental stage. It is however critical that thequantum superposition of all possible states in thecombinatorial library can be built up and scanned before theonset of decoherence. This is also the principle that forms thebasis of a quantum computer. That is why quantumcomputation is so fast.

Bottom Line: We propose that the DNA within the chromatin behaves as a dynamic combinatorial library capable of forming novel structures by reversible processes.RNA polymerase then could scan these states and the system decoheres to the "appropriate" state.Two ways of sustaining quantum coherence at relevant time scales could be possible, first, screening: the quantum system can be kept isolated from its decohering environment, second, the existence of decoherence free subspaces .We discuss the role of superconductivity in context of avoiding decoherence in context of our hypothesis.

View Article: PubMed Central - PubMed

Affiliation: National Bureau of Plant Genetic Resources, Pusa Campus, New Delhi, India ; Amity Institute of Biotechnology, Amity University, NOIDA, India.

ABSTRACT
We propose that the DNA within the chromatin behaves as a dynamic combinatorial library capable of forming novel structures by reversible processes. We also hypothesize that states within the library may be linked via quantum tunneling. RNA polymerase then could scan these states and the system decoheres to the "appropriate" state. Two ways of sustaining quantum coherence at relevant time scales could be possible, first, screening: the quantum system can be kept isolated from its decohering environment, second, the existence of decoherence free subspaces .We discuss the role of superconductivity in context of avoiding decoherence in context of our hypothesis.

No MeSH data available.