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Analysis of procalcitonin and CRP concentrations in serum of patients with chronic spontaneous urticaria.

Kasperska-Zajac A, Grzanka A, Machura E, Mazur B, Misiolek M, Czecior E, Kasperski J, Jochem J - Inflamm. Res. (2012)

Bottom Line: However, these biomarkers do not reliably differentiate between APR to infectious and the disease severity.Serum PCT and CRP concentrations were significantly increased in more severe CU patients when compared to healthy controls and mild CU, and within the CU population there was a significant correlation between concentrations of PCT and CRP.Upregulation of PCT synthesis accompanied by parallel changes in CRP concentration reflects a low-grade systemic inflammatory response in CU.

View Article: PubMed Central - PubMed

Affiliation: Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, ul. Ceglana 35, 40-952 Katowice, Poland. kasperska@plusnet.pl

ABSTRACT

Background: Our previous findings showed the importance of analysing the peripheral markers of acute phase response (APR) activation, C-reactive protein (CRP) and IL-6 in the context of urticaria activity and severity. However, these biomarkers do not reliably differentiate between APR to infectious and the disease severity.

Aim: In order to investigate a possible association between the immune-inflammatory activation markers CRP and procalcitonin (PCT).

Methods: Serum PCT and CRP concentrations were measured in patients with CU of varying severity as well as in healthy subjects.

Results: Serum PCT and CRP concentrations were significantly increased in more severe CU patients when compared to healthy controls and mild CU, and within the CU population there was a significant correlation between concentrations of PCT and CRP. Serum PCT concentrations remained within normal ranges in most CU patients and were only slightly elevated in some severe CU cases.

Conclusions: PCT serum concentration may be only slightly elevated in some cases of severe CU. Upregulation of PCT synthesis accompanied by parallel changes in CRP concentration reflects a low-grade systemic inflammatory response in CU. PCT should be considered as a better marker than CRP to distinguish between APR to infection and an active non-specific urticarial inflammation.

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Related in: MedlinePlus

Serum PCT concentration in healthy subjects and chronic urticaria (CU) patients with different disease activity. CU-mild vs. control p > 0.05, CU-moderate/severe vs. CU-mild vs. control p < 0.01
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Fig1: Serum PCT concentration in healthy subjects and chronic urticaria (CU) patients with different disease activity. CU-mild vs. control p > 0.05, CU-moderate/severe vs. CU-mild vs. control p < 0.01

Mentions: Serum PCT concentration was significantly higher in CU patients as compared with the healthy subjects (median 0.032 vs. 0.021 ng/ml, p < 0.05). PCT concentrations were significantly higher in moderate/severe CU patients as compared with mild CU patients and the healthy subjects (median: 0.045 vs. 0.021 vs. 0.022 ng/ml, p < 0.01) (Fig 1.). However, only four CU (36 %) patients had PCT slightly elevated above the normal value (defined as higher than 0.05 ng/ml).Fig. 1


Analysis of procalcitonin and CRP concentrations in serum of patients with chronic spontaneous urticaria.

Kasperska-Zajac A, Grzanka A, Machura E, Mazur B, Misiolek M, Czecior E, Kasperski J, Jochem J - Inflamm. Res. (2012)

Serum PCT concentration in healthy subjects and chronic urticaria (CU) patients with different disease activity. CU-mild vs. control p > 0.05, CU-moderate/severe vs. CU-mild vs. control p < 0.01
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3569594&req=5

Fig1: Serum PCT concentration in healthy subjects and chronic urticaria (CU) patients with different disease activity. CU-mild vs. control p > 0.05, CU-moderate/severe vs. CU-mild vs. control p < 0.01
Mentions: Serum PCT concentration was significantly higher in CU patients as compared with the healthy subjects (median 0.032 vs. 0.021 ng/ml, p < 0.05). PCT concentrations were significantly higher in moderate/severe CU patients as compared with mild CU patients and the healthy subjects (median: 0.045 vs. 0.021 vs. 0.022 ng/ml, p < 0.01) (Fig 1.). However, only four CU (36 %) patients had PCT slightly elevated above the normal value (defined as higher than 0.05 ng/ml).Fig. 1

Bottom Line: However, these biomarkers do not reliably differentiate between APR to infectious and the disease severity.Serum PCT and CRP concentrations were significantly increased in more severe CU patients when compared to healthy controls and mild CU, and within the CU population there was a significant correlation between concentrations of PCT and CRP.Upregulation of PCT synthesis accompanied by parallel changes in CRP concentration reflects a low-grade systemic inflammatory response in CU.

View Article: PubMed Central - PubMed

Affiliation: Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, ul. Ceglana 35, 40-952 Katowice, Poland. kasperska@plusnet.pl

ABSTRACT

Background: Our previous findings showed the importance of analysing the peripheral markers of acute phase response (APR) activation, C-reactive protein (CRP) and IL-6 in the context of urticaria activity and severity. However, these biomarkers do not reliably differentiate between APR to infectious and the disease severity.

Aim: In order to investigate a possible association between the immune-inflammatory activation markers CRP and procalcitonin (PCT).

Methods: Serum PCT and CRP concentrations were measured in patients with CU of varying severity as well as in healthy subjects.

Results: Serum PCT and CRP concentrations were significantly increased in more severe CU patients when compared to healthy controls and mild CU, and within the CU population there was a significant correlation between concentrations of PCT and CRP. Serum PCT concentrations remained within normal ranges in most CU patients and were only slightly elevated in some severe CU cases.

Conclusions: PCT serum concentration may be only slightly elevated in some cases of severe CU. Upregulation of PCT synthesis accompanied by parallel changes in CRP concentration reflects a low-grade systemic inflammatory response in CU. PCT should be considered as a better marker than CRP to distinguish between APR to infection and an active non-specific urticarial inflammation.

Show MeSH
Related in: MedlinePlus