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MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor.

Halon A, Materna V, Donizy P, Matkowski R, Rabczynski J, Lage H, Surowiak P - Arch. Gynecol. Obstet. (2012)

Bottom Line: To determine the prognostic value of the immunohistochemical evaluation of the multidrug resistance-associated protein 2 (MRP2) expression, together with its subcellular localization in primary fallopian tube carcinomas (PFTCs).The immunohistochemical analysis was performed using samples originating from 70 patients with PFTCs. (1) We documented that MRP2 can be localized in the plasma membrane (MRP2c), as well as in the nuclear envelope (MRP2n) of the PFTC cells. (2) Patients with more advanced stage, with progression of the disease and patients who died, showed significantly higher expression of the MRP2n. (3) Univariate and multivariate analyses showed that MRP2n is an unfavorable prognostic factor in PFTCs. (4) The analysis of the classic clinicopathological data revealed that only the FIGO stage had prognostic value, both in the univariate, as well as in multivariate analysis. (1) This study suggests that MRP2n is a new disadvantageous prognostic factor in PFTCs and (2) that expression in nuclear envelope can be associated with lower differentiation of cancer cells and their resistance to the cisplatin. (3) We have also confirmed independent prognostic value of FIGO stage in PFTCs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, Poland. ahalon2@gmail.com

ABSTRACT

Objective: To determine the prognostic value of the immunohistochemical evaluation of the multidrug resistance-associated protein 2 (MRP2) expression, together with its subcellular localization in primary fallopian tube carcinomas (PFTCs).

Methods: The immunohistochemical analysis was performed using samples originating from 70 patients with PFTCs.

Results: (1) We documented that MRP2 can be localized in the plasma membrane (MRP2c), as well as in the nuclear envelope (MRP2n) of the PFTC cells. (2) Patients with more advanced stage, with progression of the disease and patients who died, showed significantly higher expression of the MRP2n. (3) Univariate and multivariate analyses showed that MRP2n is an unfavorable prognostic factor in PFTCs. (4) The analysis of the classic clinicopathological data revealed that only the FIGO stage had prognostic value, both in the univariate, as well as in multivariate analysis.

Conclusions: (1) This study suggests that MRP2n is a new disadvantageous prognostic factor in PFTCs and (2) that expression in nuclear envelope can be associated with lower differentiation of cancer cells and their resistance to the cisplatin. (3) We have also confirmed independent prognostic value of FIGO stage in PFTCs.

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Kaplan–Meier curves for survival and expression of MRP2. a Cytoplasmic MRP2 expression and patients survival (entire studied group), b nuclear envelope MRP2 expression and patients survival (entire studied group), c cytoplasmic MRP2 expression and patients survival (chemotherapy-treated subgroup), d nuclear envelope MRP2 expression and patients survival (chemotherapy-treated subgroup)
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Fig2: Kaplan–Meier curves for survival and expression of MRP2. a Cytoplasmic MRP2 expression and patients survival (entire studied group), b nuclear envelope MRP2 expression and patients survival (entire studied group), c cytoplasmic MRP2 expression and patients survival (chemotherapy-treated subgroup), d nuclear envelope MRP2 expression and patients survival (chemotherapy-treated subgroup)

Mentions: Using the log-rank test and the Kaplan–Meier’s analysis, we revealed that the MRP2c expression has no prognostic value (Fig. 2a). In the case of the MRP2n, we observed shorter overall survival time in group of patients with higher expression of the MRP2n (IRS 3–12) compared to the group with lower expression of the MRP2n (IRS 0–2) (Fig. 2b).Fig. 2


MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor.

Halon A, Materna V, Donizy P, Matkowski R, Rabczynski J, Lage H, Surowiak P - Arch. Gynecol. Obstet. (2012)

Kaplan–Meier curves for survival and expression of MRP2. a Cytoplasmic MRP2 expression and patients survival (entire studied group), b nuclear envelope MRP2 expression and patients survival (entire studied group), c cytoplasmic MRP2 expression and patients survival (chemotherapy-treated subgroup), d nuclear envelope MRP2 expression and patients survival (chemotherapy-treated subgroup)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3569580&req=5

Fig2: Kaplan–Meier curves for survival and expression of MRP2. a Cytoplasmic MRP2 expression and patients survival (entire studied group), b nuclear envelope MRP2 expression and patients survival (entire studied group), c cytoplasmic MRP2 expression and patients survival (chemotherapy-treated subgroup), d nuclear envelope MRP2 expression and patients survival (chemotherapy-treated subgroup)
Mentions: Using the log-rank test and the Kaplan–Meier’s analysis, we revealed that the MRP2c expression has no prognostic value (Fig. 2a). In the case of the MRP2n, we observed shorter overall survival time in group of patients with higher expression of the MRP2n (IRS 3–12) compared to the group with lower expression of the MRP2n (IRS 0–2) (Fig. 2b).Fig. 2

Bottom Line: To determine the prognostic value of the immunohistochemical evaluation of the multidrug resistance-associated protein 2 (MRP2) expression, together with its subcellular localization in primary fallopian tube carcinomas (PFTCs).The immunohistochemical analysis was performed using samples originating from 70 patients with PFTCs. (1) We documented that MRP2 can be localized in the plasma membrane (MRP2c), as well as in the nuclear envelope (MRP2n) of the PFTC cells. (2) Patients with more advanced stage, with progression of the disease and patients who died, showed significantly higher expression of the MRP2n. (3) Univariate and multivariate analyses showed that MRP2n is an unfavorable prognostic factor in PFTCs. (4) The analysis of the classic clinicopathological data revealed that only the FIGO stage had prognostic value, both in the univariate, as well as in multivariate analysis. (1) This study suggests that MRP2n is a new disadvantageous prognostic factor in PFTCs and (2) that expression in nuclear envelope can be associated with lower differentiation of cancer cells and their resistance to the cisplatin. (3) We have also confirmed independent prognostic value of FIGO stage in PFTCs.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, Poland. ahalon2@gmail.com

ABSTRACT

Objective: To determine the prognostic value of the immunohistochemical evaluation of the multidrug resistance-associated protein 2 (MRP2) expression, together with its subcellular localization in primary fallopian tube carcinomas (PFTCs).

Methods: The immunohistochemical analysis was performed using samples originating from 70 patients with PFTCs.

Results: (1) We documented that MRP2 can be localized in the plasma membrane (MRP2c), as well as in the nuclear envelope (MRP2n) of the PFTC cells. (2) Patients with more advanced stage, with progression of the disease and patients who died, showed significantly higher expression of the MRP2n. (3) Univariate and multivariate analyses showed that MRP2n is an unfavorable prognostic factor in PFTCs. (4) The analysis of the classic clinicopathological data revealed that only the FIGO stage had prognostic value, both in the univariate, as well as in multivariate analysis.

Conclusions: (1) This study suggests that MRP2n is a new disadvantageous prognostic factor in PFTCs and (2) that expression in nuclear envelope can be associated with lower differentiation of cancer cells and their resistance to the cisplatin. (3) We have also confirmed independent prognostic value of FIGO stage in PFTCs.

Show MeSH
Related in: MedlinePlus