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Advanced Cardiac MR Imaging for Myocardial Characterization and Quantification: T1 Mapping.

Hwang SH, Choi BW - Korean Circ J (2013)

Bottom Line: Although late gadolinium enhancement after injection of the gadolinium extracellular contrast agent has further extended our ability to characterize the myocardial tissue, it also has limitations in the quantification of enhanced myocardial tissue pathology, and the detection of diffuse myocardial disease, which is not easily recognized by enhancement contrast.Recently, the remarkable advances in CMR technique, such as T1 mapping, which can quantitatively evaluate myocardial status, showed potentials to overcome limitations of existing CMR sequences and to expand the application of CMR.This article will review the technical and clinical points to be considered in the practical use of pre- and post-contrast T1 mapping.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
Magnetic resonance as an imaging modality provides an excellent soft tissue differentiation, which is an ideal choice for cardiac imaging. Cardiac magnetic resonance (CMR) allows myocardial tissue characterization, as well as comprehensive evaluation of the structures. Although late gadolinium enhancement after injection of the gadolinium extracellular contrast agent has further extended our ability to characterize the myocardial tissue, it also has limitations in the quantification of enhanced myocardial tissue pathology, and the detection of diffuse myocardial disease, which is not easily recognized by enhancement contrast. Recently, the remarkable advances in CMR technique, such as T1 mapping, which can quantitatively evaluate myocardial status, showed potentials to overcome limitations of existing CMR sequences and to expand the application of CMR. This article will review the technical and clinical points to be considered in the practical use of pre- and post-contrast T1 mapping.

No MeSH data available.


Related in: MedlinePlus

Late gadolinium enhancement (LGE) (A), pre- and post-contrast (B and C) T1 map images using 3-T MR system in a patients with prior myocardial infarction in the lateral wall. LGE-MR image shows strong subendocardial enhancement and diffuse wall thinning from chronic infarction in the left anterior descending artery territory of the middle left ventricle level. Post-contrast T1 map image shows a marked T1 shortening in the peri-infarct region, which is not grossly enhanced on LGE image, when compared to the remote zone.
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Figure 1: Late gadolinium enhancement (LGE) (A), pre- and post-contrast (B and C) T1 map images using 3-T MR system in a patients with prior myocardial infarction in the lateral wall. LGE-MR image shows strong subendocardial enhancement and diffuse wall thinning from chronic infarction in the left anterior descending artery territory of the middle left ventricle level. Post-contrast T1 map image shows a marked T1 shortening in the peri-infarct region, which is not grossly enhanced on LGE image, when compared to the remote zone.

Mentions: Although the qualitative evaluation of myocardium by existing CMR sequence has been a robust technique to characterize the myocardium, the relative signal intensity changes due to variation in CMR acquisition parameter may limit the evaluation of full spectrum of myocardial disease.9)10) Up-to-date advance in MR techniques can allow a rapid quantitative assessment of T1 values, "T1 mapping" as a promising method to characterize the myocardium (Fig. 1). In addition, post-contrast T1 mapping with using of the gadolinium can quantify the myocardial extracellular volume fraction (ECV) correlated with histologic evidence of myocardial fibrosis.10-12)


Advanced Cardiac MR Imaging for Myocardial Characterization and Quantification: T1 Mapping.

Hwang SH, Choi BW - Korean Circ J (2013)

Late gadolinium enhancement (LGE) (A), pre- and post-contrast (B and C) T1 map images using 3-T MR system in a patients with prior myocardial infarction in the lateral wall. LGE-MR image shows strong subendocardial enhancement and diffuse wall thinning from chronic infarction in the left anterior descending artery territory of the middle left ventricle level. Post-contrast T1 map image shows a marked T1 shortening in the peri-infarct region, which is not grossly enhanced on LGE image, when compared to the remote zone.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569561&req=5

Figure 1: Late gadolinium enhancement (LGE) (A), pre- and post-contrast (B and C) T1 map images using 3-T MR system in a patients with prior myocardial infarction in the lateral wall. LGE-MR image shows strong subendocardial enhancement and diffuse wall thinning from chronic infarction in the left anterior descending artery territory of the middle left ventricle level. Post-contrast T1 map image shows a marked T1 shortening in the peri-infarct region, which is not grossly enhanced on LGE image, when compared to the remote zone.
Mentions: Although the qualitative evaluation of myocardium by existing CMR sequence has been a robust technique to characterize the myocardium, the relative signal intensity changes due to variation in CMR acquisition parameter may limit the evaluation of full spectrum of myocardial disease.9)10) Up-to-date advance in MR techniques can allow a rapid quantitative assessment of T1 values, "T1 mapping" as a promising method to characterize the myocardium (Fig. 1). In addition, post-contrast T1 mapping with using of the gadolinium can quantify the myocardial extracellular volume fraction (ECV) correlated with histologic evidence of myocardial fibrosis.10-12)

Bottom Line: Although late gadolinium enhancement after injection of the gadolinium extracellular contrast agent has further extended our ability to characterize the myocardial tissue, it also has limitations in the quantification of enhanced myocardial tissue pathology, and the detection of diffuse myocardial disease, which is not easily recognized by enhancement contrast.Recently, the remarkable advances in CMR technique, such as T1 mapping, which can quantitatively evaluate myocardial status, showed potentials to overcome limitations of existing CMR sequences and to expand the application of CMR.This article will review the technical and clinical points to be considered in the practical use of pre- and post-contrast T1 mapping.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
Magnetic resonance as an imaging modality provides an excellent soft tissue differentiation, which is an ideal choice for cardiac imaging. Cardiac magnetic resonance (CMR) allows myocardial tissue characterization, as well as comprehensive evaluation of the structures. Although late gadolinium enhancement after injection of the gadolinium extracellular contrast agent has further extended our ability to characterize the myocardial tissue, it also has limitations in the quantification of enhanced myocardial tissue pathology, and the detection of diffuse myocardial disease, which is not easily recognized by enhancement contrast. Recently, the remarkable advances in CMR technique, such as T1 mapping, which can quantitatively evaluate myocardial status, showed potentials to overcome limitations of existing CMR sequences and to expand the application of CMR. This article will review the technical and clinical points to be considered in the practical use of pre- and post-contrast T1 mapping.

No MeSH data available.


Related in: MedlinePlus