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A rare case of primary infiltrating neuroendocrine carcinoma of the breast.

Nawawi O, Ying Goh K, Rahmat K - Iran J Radiol (2012)

Bottom Line: There are not many cases reported in the English literature since it was first documented in 1983.Reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce.Herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, masquerading as an inflammatory breast condition in a 22-year-old young lady, perhaps the youngest case ever reported in the English literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Imaging, University of Malaya Medical Center, Kuala Lumpur, Malaysia.

ABSTRACT
Primary neuroendocrine carcinoma of the breast is a very rare malignant tumor. There are not many cases reported in the English literature since it was first documented in 1983. Reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce. Herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, masquerading as an inflammatory breast condition in a 22-year-old young lady, perhaps the youngest case ever reported in the English literature. We discuss the imaging features and highlight the Doppler ultrasonographic findings of this rare breast carcinoma. This is the first documentation on Doppler ultrasonographic findings of primary neuroendocrine carcinoma of the breast in the literature.

No MeSH data available.


Related in: MedlinePlus

A, Histopathology of section of the tumor showing partly necrotic, focally crushed fragments of fibrofatty tissue exhibiting clusters and trabeculae of malignant epithelial cells surrounded by desmoplastic stroma (H & E stain × 10); B, The tumor cells exhibit moderately pleomorphic hyperchromatic nuclei, scanty cytoplasm and high mitotic activity (H & E stain × 40).
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fig488: A, Histopathology of section of the tumor showing partly necrotic, focally crushed fragments of fibrofatty tissue exhibiting clusters and trabeculae of malignant epithelial cells surrounded by desmoplastic stroma (H & E stain × 10); B, The tumor cells exhibit moderately pleomorphic hyperchromatic nuclei, scanty cytoplasm and high mitotic activity (H & E stain × 40).

Mentions: Histopathological examination of the core tissue revealed partly necrotic, focally crushed fragments of fibrofatty tissue exhibiting clusters and trabeculae of malignant epithelial cells surrounded by desmoplastic stroma. There was no obvious tubule or gland formation. The tumor cells exhibit moderately pleomorphic hyperchromatic nuclei, scanty cytoplasm and a high mitotic activity (10/10 hpf) (Figure 2). Numerous apoptotic bodies were noted. Immunohisto chemically, the tumor cells were immune positive for synaptophysin, chromogranin and MNF116. Interpretation of the result was infiltrating neuroendocrine carcinoma of the breast. The patient initially refused further imaging or treatment, but returned to the clinic a month later. This time the breast mass had grown larger associated with skin ulceration. The previously palpable right axillary nodes had also become larger and fixed. A contrast enhanced computed tomography (CT) examination of the thorax, abdomen and pelvis revealed a heterogeneously enhancing mass 5.4 × 13.8 × 11.0 cm in size, occupying the whole of the right breast. The mass infiltrated the underlying pectoralis major muscle and a part of the underlying chest wall. Multiple enhancing enlarged right axillary lymph nodes were present (Figure 3). The left breast and axilla were normal. There was no significant abnormality detected in the rest of the thorax, abdomen or pelvis and including the visualized spine bones.


A rare case of primary infiltrating neuroendocrine carcinoma of the breast.

Nawawi O, Ying Goh K, Rahmat K - Iran J Radiol (2012)

A, Histopathology of section of the tumor showing partly necrotic, focally crushed fragments of fibrofatty tissue exhibiting clusters and trabeculae of malignant epithelial cells surrounded by desmoplastic stroma (H & E stain × 10); B, The tumor cells exhibit moderately pleomorphic hyperchromatic nuclei, scanty cytoplasm and high mitotic activity (H & E stain × 40).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569554&req=5

fig488: A, Histopathology of section of the tumor showing partly necrotic, focally crushed fragments of fibrofatty tissue exhibiting clusters and trabeculae of malignant epithelial cells surrounded by desmoplastic stroma (H & E stain × 10); B, The tumor cells exhibit moderately pleomorphic hyperchromatic nuclei, scanty cytoplasm and high mitotic activity (H & E stain × 40).
Mentions: Histopathological examination of the core tissue revealed partly necrotic, focally crushed fragments of fibrofatty tissue exhibiting clusters and trabeculae of malignant epithelial cells surrounded by desmoplastic stroma. There was no obvious tubule or gland formation. The tumor cells exhibit moderately pleomorphic hyperchromatic nuclei, scanty cytoplasm and a high mitotic activity (10/10 hpf) (Figure 2). Numerous apoptotic bodies were noted. Immunohisto chemically, the tumor cells were immune positive for synaptophysin, chromogranin and MNF116. Interpretation of the result was infiltrating neuroendocrine carcinoma of the breast. The patient initially refused further imaging or treatment, but returned to the clinic a month later. This time the breast mass had grown larger associated with skin ulceration. The previously palpable right axillary nodes had also become larger and fixed. A contrast enhanced computed tomography (CT) examination of the thorax, abdomen and pelvis revealed a heterogeneously enhancing mass 5.4 × 13.8 × 11.0 cm in size, occupying the whole of the right breast. The mass infiltrated the underlying pectoralis major muscle and a part of the underlying chest wall. Multiple enhancing enlarged right axillary lymph nodes were present (Figure 3). The left breast and axilla were normal. There was no significant abnormality detected in the rest of the thorax, abdomen or pelvis and including the visualized spine bones.

Bottom Line: There are not many cases reported in the English literature since it was first documented in 1983.Reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce.Herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, masquerading as an inflammatory breast condition in a 22-year-old young lady, perhaps the youngest case ever reported in the English literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Imaging, University of Malaya Medical Center, Kuala Lumpur, Malaysia.

ABSTRACT
Primary neuroendocrine carcinoma of the breast is a very rare malignant tumor. There are not many cases reported in the English literature since it was first documented in 1983. Reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce. Herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, masquerading as an inflammatory breast condition in a 22-year-old young lady, perhaps the youngest case ever reported in the English literature. We discuss the imaging features and highlight the Doppler ultrasonographic findings of this rare breast carcinoma. This is the first documentation on Doppler ultrasonographic findings of primary neuroendocrine carcinoma of the breast in the literature.

No MeSH data available.


Related in: MedlinePlus