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A rare case of primary infiltrating neuroendocrine carcinoma of the breast.

Nawawi O, Ying Goh K, Rahmat K - Iran J Radiol (2012)

Bottom Line: There are not many cases reported in the English literature since it was first documented in 1983.Reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce.Herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, masquerading as an inflammatory breast condition in a 22-year-old young lady, perhaps the youngest case ever reported in the English literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Imaging, University of Malaya Medical Center, Kuala Lumpur, Malaysia.

ABSTRACT
Primary neuroendocrine carcinoma of the breast is a very rare malignant tumor. There are not many cases reported in the English literature since it was first documented in 1983. Reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce. Herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, masquerading as an inflammatory breast condition in a 22-year-old young lady, perhaps the youngest case ever reported in the English literature. We discuss the imaging features and highlight the Doppler ultrasonographic findings of this rare breast carcinoma. This is the first documentation on Doppler ultrasonographic findings of primary neuroendocrine carcinoma of the breast in the literature.

No MeSH data available.


Related in: MedlinePlus

A and B, Gray-scale ultrasound examination of the right breast showing large partially delineated hypoechoic mass containing small cystic areas (white arrows) and echogenic foci (black arrows). The surrounding breast parenchyma showed heterogeneous echotexture; C, The mass is closely related to the nipple causing nipple retraction and fixation; D, Color-Doppler ultrasound study showed low intra-tumoral vascularity with moderate flow signal surrounding the mass.
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fig487: A and B, Gray-scale ultrasound examination of the right breast showing large partially delineated hypoechoic mass containing small cystic areas (white arrows) and echogenic foci (black arrows). The surrounding breast parenchyma showed heterogeneous echotexture; C, The mass is closely related to the nipple causing nipple retraction and fixation; D, Color-Doppler ultrasound study showed low intra-tumoral vascularity with moderate flow signal surrounding the mass.

Mentions: On physical examination, the right breast was markedly swollen and tender. The overlying skin was warm and erythematous. A large firm mass was felt predominantly in the lower quadrants of the right breast. It was fixed to the superficial skin, nipple and underlying muscle. Several right axillary lymph nodes were palpable. The left breast and the left axilla were normal. She was afebrile with stable vital signs. Examination of the other systems was unremarkable. Blood investigation revealed normal parameters. She was immediately referred for a breast ultrasonography after a core biopsy of the mass was performed in the breast clinic. Ultrasound examination of the right breast revealed a large lobulated hypoechoic solid lesion occupying the lower quadrants and extending to the retroareolar region. The nipple was retracted towards the mass. The mass measured approximately 8.0 cm in width and 3.9 cm in height and contained cystic areas and few hyperechoic foci. The margin of the mass was partially well-delineated and mildly lobulated. Neither posterior acoustic enhancement nor shadowing was present. The surrounding breast parenchyma was heterogeneous and edematous. There was no satellite nodule. Color-Doppler study of the lesion showed minimal flow signal seen only at the medial side of the periphery of the mass. The rest of the mass was generally avascular. No penetrating vessel into the mass was seen. A moderate amount of flow signal was documented in the stroma surrounding the mass (Figure 1). Multiple enlarged right axillary lymph nodes with loss of the fatty hilum were noted with the largest measuring 1.9 × 1.2 cm. Ultrasound of the left breast and axilla was normal.


A rare case of primary infiltrating neuroendocrine carcinoma of the breast.

Nawawi O, Ying Goh K, Rahmat K - Iran J Radiol (2012)

A and B, Gray-scale ultrasound examination of the right breast showing large partially delineated hypoechoic mass containing small cystic areas (white arrows) and echogenic foci (black arrows). The surrounding breast parenchyma showed heterogeneous echotexture; C, The mass is closely related to the nipple causing nipple retraction and fixation; D, Color-Doppler ultrasound study showed low intra-tumoral vascularity with moderate flow signal surrounding the mass.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569554&req=5

fig487: A and B, Gray-scale ultrasound examination of the right breast showing large partially delineated hypoechoic mass containing small cystic areas (white arrows) and echogenic foci (black arrows). The surrounding breast parenchyma showed heterogeneous echotexture; C, The mass is closely related to the nipple causing nipple retraction and fixation; D, Color-Doppler ultrasound study showed low intra-tumoral vascularity with moderate flow signal surrounding the mass.
Mentions: On physical examination, the right breast was markedly swollen and tender. The overlying skin was warm and erythematous. A large firm mass was felt predominantly in the lower quadrants of the right breast. It was fixed to the superficial skin, nipple and underlying muscle. Several right axillary lymph nodes were palpable. The left breast and the left axilla were normal. She was afebrile with stable vital signs. Examination of the other systems was unremarkable. Blood investigation revealed normal parameters. She was immediately referred for a breast ultrasonography after a core biopsy of the mass was performed in the breast clinic. Ultrasound examination of the right breast revealed a large lobulated hypoechoic solid lesion occupying the lower quadrants and extending to the retroareolar region. The nipple was retracted towards the mass. The mass measured approximately 8.0 cm in width and 3.9 cm in height and contained cystic areas and few hyperechoic foci. The margin of the mass was partially well-delineated and mildly lobulated. Neither posterior acoustic enhancement nor shadowing was present. The surrounding breast parenchyma was heterogeneous and edematous. There was no satellite nodule. Color-Doppler study of the lesion showed minimal flow signal seen only at the medial side of the periphery of the mass. The rest of the mass was generally avascular. No penetrating vessel into the mass was seen. A moderate amount of flow signal was documented in the stroma surrounding the mass (Figure 1). Multiple enlarged right axillary lymph nodes with loss of the fatty hilum were noted with the largest measuring 1.9 × 1.2 cm. Ultrasound of the left breast and axilla was normal.

Bottom Line: There are not many cases reported in the English literature since it was first documented in 1983.Reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce.Herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, masquerading as an inflammatory breast condition in a 22-year-old young lady, perhaps the youngest case ever reported in the English literature.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Imaging, University of Malaya Medical Center, Kuala Lumpur, Malaysia.

ABSTRACT
Primary neuroendocrine carcinoma of the breast is a very rare malignant tumor. There are not many cases reported in the English literature since it was first documented in 1983. Reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce. Herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, masquerading as an inflammatory breast condition in a 22-year-old young lady, perhaps the youngest case ever reported in the English literature. We discuss the imaging features and highlight the Doppler ultrasonographic findings of this rare breast carcinoma. This is the first documentation on Doppler ultrasonographic findings of primary neuroendocrine carcinoma of the breast in the literature.

No MeSH data available.


Related in: MedlinePlus