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Super, red palm and palm oleins improve the blood pressure, heart size, aortic media thickness and lipid profile in spontaneously hypertensive rats.

Boon CM, Ng MH, Choo YM, Mok SL - PLoS ONE (2013)

Bottom Line: The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter.Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT

Background: Oleic acid has been shown to lower high blood pressure and provide cardiovascular protection. Curiosity arises as to whether super olein (SO), red palm olein (RPO) and palm olein (PO), which have high oleic acid content, are able to prevent the development of hypertension.

Methodology/principal findings: Four-week-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were fed 15% SO, RPO or PO supplemented diet for 15 weeks. After 15 weeks of treatment, the systolic blood pressure (SBP) of SHR treated with SO, RPO and PO were 158.4±5.0 mmHg (p<0.001), 178.9±2.7 mmHg (p<0.001) and 167.7±2.1 mmHg (p<0.001), respectively, compared with SHR controls (220.9±1.5 mmHg). Bradycardia was observed with SO and PO. In contrast, the SBP and heart rate of treated WKY rats were not different from those of WKY controls. The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter. No such differences, however, were observed between the treated and untreated WKY rats. Oil Red O enface staining of thoracic-abdominal aorta did not show any lipid deposition in all treated rats. The SO and RPO significantly raised serum alkaline phosphatase levels in the SHR while body weight and renal biochemical indices were unaltered in both strains. Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.

Conclusion: The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO. The SO and RPO are antiatherogenic in nature by improving blood lipid profiles in SHR.

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Photomicrograph of thoracic aorta from treated and untreated WKY rats at 400× magnification.Hematoxylin and eosin stained aorta: A. Control WKY. B. SO treated WKY. C. RPO treated WKY. D. PO treated WKY. No significant changes were observed in the aortic media thickness between the treated and control WKY rats.
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pone-0055908-g004: Photomicrograph of thoracic aorta from treated and untreated WKY rats at 400× magnification.Hematoxylin and eosin stained aorta: A. Control WKY. B. SO treated WKY. C. RPO treated WKY. D. PO treated WKY. No significant changes were observed in the aortic media thickness between the treated and control WKY rats.

Mentions: Morphological differences in the aortic media thickness of treated and control SHR, and treated and control WKY rats are presented in Figures 3A–D and 4A–D, respectively. One-way ANOVA showed that treatments with SO, RPO and PO had a significant effect on the aortic media thickness (p<0.001) in the SHR and not in WKY rats (Table 3). The aortic media thickness was 202.4±3.8 µm in the SHR controls and was significantly reduced in SHR treated with SO (178.4±5.1 µm, p<0.01), RPO (181.1±4.1 µm, p<0.01) and PO (178.6±1.7 µm, p<0.01) (Table 3). On the other hand, no significant differences were observed between SO (131.7±5.6 µm), RPO (131.6±2.0 µm) and PO (131.1±5.3 µm) treated WKY rats compared with WKY controls (131.5±7.6 µm) (Table 3). Enface staining of the thoracic-abdominal aorta with Oil Red O did not show any lipid depositions in all the treated and untreated rats of both strains, and as such figures were not included here.


Super, red palm and palm oleins improve the blood pressure, heart size, aortic media thickness and lipid profile in spontaneously hypertensive rats.

Boon CM, Ng MH, Choo YM, Mok SL - PLoS ONE (2013)

Photomicrograph of thoracic aorta from treated and untreated WKY rats at 400× magnification.Hematoxylin and eosin stained aorta: A. Control WKY. B. SO treated WKY. C. RPO treated WKY. D. PO treated WKY. No significant changes were observed in the aortic media thickness between the treated and control WKY rats.
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Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3569425&req=5

pone-0055908-g004: Photomicrograph of thoracic aorta from treated and untreated WKY rats at 400× magnification.Hematoxylin and eosin stained aorta: A. Control WKY. B. SO treated WKY. C. RPO treated WKY. D. PO treated WKY. No significant changes were observed in the aortic media thickness between the treated and control WKY rats.
Mentions: Morphological differences in the aortic media thickness of treated and control SHR, and treated and control WKY rats are presented in Figures 3A–D and 4A–D, respectively. One-way ANOVA showed that treatments with SO, RPO and PO had a significant effect on the aortic media thickness (p<0.001) in the SHR and not in WKY rats (Table 3). The aortic media thickness was 202.4±3.8 µm in the SHR controls and was significantly reduced in SHR treated with SO (178.4±5.1 µm, p<0.01), RPO (181.1±4.1 µm, p<0.01) and PO (178.6±1.7 µm, p<0.01) (Table 3). On the other hand, no significant differences were observed between SO (131.7±5.6 µm), RPO (131.6±2.0 µm) and PO (131.1±5.3 µm) treated WKY rats compared with WKY controls (131.5±7.6 µm) (Table 3). Enface staining of the thoracic-abdominal aorta with Oil Red O did not show any lipid depositions in all the treated and untreated rats of both strains, and as such figures were not included here.

Bottom Line: The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter.Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT

Background: Oleic acid has been shown to lower high blood pressure and provide cardiovascular protection. Curiosity arises as to whether super olein (SO), red palm olein (RPO) and palm olein (PO), which have high oleic acid content, are able to prevent the development of hypertension.

Methodology/principal findings: Four-week-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were fed 15% SO, RPO or PO supplemented diet for 15 weeks. After 15 weeks of treatment, the systolic blood pressure (SBP) of SHR treated with SO, RPO and PO were 158.4±5.0 mmHg (p<0.001), 178.9±2.7 mmHg (p<0.001) and 167.7±2.1 mmHg (p<0.001), respectively, compared with SHR controls (220.9±1.5 mmHg). Bradycardia was observed with SO and PO. In contrast, the SBP and heart rate of treated WKY rats were not different from those of WKY controls. The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter. No such differences, however, were observed between the treated and untreated WKY rats. Oil Red O enface staining of thoracic-abdominal aorta did not show any lipid deposition in all treated rats. The SO and RPO significantly raised serum alkaline phosphatase levels in the SHR while body weight and renal biochemical indices were unaltered in both strains. Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.

Conclusion: The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO. The SO and RPO are antiatherogenic in nature by improving blood lipid profiles in SHR.

Show MeSH
Related in: MedlinePlus