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Super, red palm and palm oleins improve the blood pressure, heart size, aortic media thickness and lipid profile in spontaneously hypertensive rats.

Boon CM, Ng MH, Choo YM, Mok SL - PLoS ONE (2013)

Bottom Line: The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter.Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT

Background: Oleic acid has been shown to lower high blood pressure and provide cardiovascular protection. Curiosity arises as to whether super olein (SO), red palm olein (RPO) and palm olein (PO), which have high oleic acid content, are able to prevent the development of hypertension.

Methodology/principal findings: Four-week-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were fed 15% SO, RPO or PO supplemented diet for 15 weeks. After 15 weeks of treatment, the systolic blood pressure (SBP) of SHR treated with SO, RPO and PO were 158.4±5.0 mmHg (p<0.001), 178.9±2.7 mmHg (p<0.001) and 167.7±2.1 mmHg (p<0.001), respectively, compared with SHR controls (220.9±1.5 mmHg). Bradycardia was observed with SO and PO. In contrast, the SBP and heart rate of treated WKY rats were not different from those of WKY controls. The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter. No such differences, however, were observed between the treated and untreated WKY rats. Oil Red O enface staining of thoracic-abdominal aorta did not show any lipid deposition in all treated rats. The SO and RPO significantly raised serum alkaline phosphatase levels in the SHR while body weight and renal biochemical indices were unaltered in both strains. Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.

Conclusion: The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO. The SO and RPO are antiatherogenic in nature by improving blood lipid profiles in SHR.

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Related in: MedlinePlus

Calorie intake and body weight of treated and untreated SHR and WKY rats.The graphs show daily calorie intake and weekly body weight gain in SHR and WKY rats fed super olein (SO), red palm olein (RPO) and palm olein (PO) supplemented diets from 4–19 weeks of age, at 0–15 weeks of treatment period. Calorie intake of treated SHR and its controls (A), and treated WKY and its controls (B). Body weight of treated SHR and its controls (C), and treated WKY and its controls (D). Each point represents mean±SEM (n = 6).
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pone-0055908-g002: Calorie intake and body weight of treated and untreated SHR and WKY rats.The graphs show daily calorie intake and weekly body weight gain in SHR and WKY rats fed super olein (SO), red palm olein (RPO) and palm olein (PO) supplemented diets from 4–19 weeks of age, at 0–15 weeks of treatment period. Calorie intake of treated SHR and its controls (A), and treated WKY and its controls (B). Body weight of treated SHR and its controls (C), and treated WKY and its controls (D). Each point represents mean±SEM (n = 6).

Mentions: All the treated and untreated SHR and WKY rats did not show any significant differences in their daily caloric intake expressed in kilocalorie (kcal) (Figs. 2A and 2B).


Super, red palm and palm oleins improve the blood pressure, heart size, aortic media thickness and lipid profile in spontaneously hypertensive rats.

Boon CM, Ng MH, Choo YM, Mok SL - PLoS ONE (2013)

Calorie intake and body weight of treated and untreated SHR and WKY rats.The graphs show daily calorie intake and weekly body weight gain in SHR and WKY rats fed super olein (SO), red palm olein (RPO) and palm olein (PO) supplemented diets from 4–19 weeks of age, at 0–15 weeks of treatment period. Calorie intake of treated SHR and its controls (A), and treated WKY and its controls (B). Body weight of treated SHR and its controls (C), and treated WKY and its controls (D). Each point represents mean±SEM (n = 6).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3569425&req=5

pone-0055908-g002: Calorie intake and body weight of treated and untreated SHR and WKY rats.The graphs show daily calorie intake and weekly body weight gain in SHR and WKY rats fed super olein (SO), red palm olein (RPO) and palm olein (PO) supplemented diets from 4–19 weeks of age, at 0–15 weeks of treatment period. Calorie intake of treated SHR and its controls (A), and treated WKY and its controls (B). Body weight of treated SHR and its controls (C), and treated WKY and its controls (D). Each point represents mean±SEM (n = 6).
Mentions: All the treated and untreated SHR and WKY rats did not show any significant differences in their daily caloric intake expressed in kilocalorie (kcal) (Figs. 2A and 2B).

Bottom Line: The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter.Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT

Background: Oleic acid has been shown to lower high blood pressure and provide cardiovascular protection. Curiosity arises as to whether super olein (SO), red palm olein (RPO) and palm olein (PO), which have high oleic acid content, are able to prevent the development of hypertension.

Methodology/principal findings: Four-week-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were fed 15% SO, RPO or PO supplemented diet for 15 weeks. After 15 weeks of treatment, the systolic blood pressure (SBP) of SHR treated with SO, RPO and PO were 158.4±5.0 mmHg (p<0.001), 178.9±2.7 mmHg (p<0.001) and 167.7±2.1 mmHg (p<0.001), respectively, compared with SHR controls (220.9±1.5 mmHg). Bradycardia was observed with SO and PO. In contrast, the SBP and heart rate of treated WKY rats were not different from those of WKY controls. The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter. No such differences, however, were observed between the treated and untreated WKY rats. Oil Red O enface staining of thoracic-abdominal aorta did not show any lipid deposition in all treated rats. The SO and RPO significantly raised serum alkaline phosphatase levels in the SHR while body weight and renal biochemical indices were unaltered in both strains. Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.

Conclusion: The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO. The SO and RPO are antiatherogenic in nature by improving blood lipid profiles in SHR.

Show MeSH
Related in: MedlinePlus