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Super, red palm and palm oleins improve the blood pressure, heart size, aortic media thickness and lipid profile in spontaneously hypertensive rats.

Boon CM, Ng MH, Choo YM, Mok SL - PLoS ONE (2013)

Bottom Line: The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter.Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT

Background: Oleic acid has been shown to lower high blood pressure and provide cardiovascular protection. Curiosity arises as to whether super olein (SO), red palm olein (RPO) and palm olein (PO), which have high oleic acid content, are able to prevent the development of hypertension.

Methodology/principal findings: Four-week-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were fed 15% SO, RPO or PO supplemented diet for 15 weeks. After 15 weeks of treatment, the systolic blood pressure (SBP) of SHR treated with SO, RPO and PO were 158.4±5.0 mmHg (p<0.001), 178.9±2.7 mmHg (p<0.001) and 167.7±2.1 mmHg (p<0.001), respectively, compared with SHR controls (220.9±1.5 mmHg). Bradycardia was observed with SO and PO. In contrast, the SBP and heart rate of treated WKY rats were not different from those of WKY controls. The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter. No such differences, however, were observed between the treated and untreated WKY rats. Oil Red O enface staining of thoracic-abdominal aorta did not show any lipid deposition in all treated rats. The SO and RPO significantly raised serum alkaline phosphatase levels in the SHR while body weight and renal biochemical indices were unaltered in both strains. Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.

Conclusion: The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO. The SO and RPO are antiatherogenic in nature by improving blood lipid profiles in SHR.

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Time course of effect of oil supplementation on systolic blood pressure and heart rate.The graphs show the effect of super olein (SO), red palm olein (RPO) and palm olein (PO) supplemented diets on the systolic blood pressure (SBP) and heart rate (HR) in SHR and WKY rats from 4–19 weeks of age, at 0–15 weeks treatment period. SBP and HR of treated SHR and its controls (A and B, respectively). SBP and HR of treated WKY rats and its controls (C and D, respectively). Each point represents mean±SEM (n = 6). Two-way ANOVA was used for statistical comparisons between the different treated groups and their strain-matched controls on the SBP and HR changes over the whole duration of treatment. ***p<0.001, compared with SHR controls; ###p<0.001, compared with RPO; @p<0.05, compared with PO.
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pone-0055908-g001: Time course of effect of oil supplementation on systolic blood pressure and heart rate.The graphs show the effect of super olein (SO), red palm olein (RPO) and palm olein (PO) supplemented diets on the systolic blood pressure (SBP) and heart rate (HR) in SHR and WKY rats from 4–19 weeks of age, at 0–15 weeks treatment period. SBP and HR of treated SHR and its controls (A and B, respectively). SBP and HR of treated WKY rats and its controls (C and D, respectively). Each point represents mean±SEM (n = 6). Two-way ANOVA was used for statistical comparisons between the different treated groups and their strain-matched controls on the SBP and HR changes over the whole duration of treatment. ***p<0.001, compared with SHR controls; ###p<0.001, compared with RPO; @p<0.05, compared with PO.

Mentions: The SO, RPO and PO markedly attenuated the rise in BP in the SHR over the whole duration of treatment (Fig. 1A). The SBP of SHR was significantly lower following treatments with SO (F1,15 = 42.38, p<0.001), RPO (F1,15 = 18.22, p<0.001) and PO (F1,15 = 29.80, p<0.001) compared with SHR controls, when the whole duration of treatment was assessed by two-way ANOVA. Meanwhile, the HR of SO treated SHR (F1,15 = 3.119, p<0.001), but not the PO (F1,15 = 0.0722) or RPO treated SHR (F1,15 = 0.1054), was significantly reduced compared with SHR controls (two-way ANOVA; Fig. 1B).


Super, red palm and palm oleins improve the blood pressure, heart size, aortic media thickness and lipid profile in spontaneously hypertensive rats.

Boon CM, Ng MH, Choo YM, Mok SL - PLoS ONE (2013)

Time course of effect of oil supplementation on systolic blood pressure and heart rate.The graphs show the effect of super olein (SO), red palm olein (RPO) and palm olein (PO) supplemented diets on the systolic blood pressure (SBP) and heart rate (HR) in SHR and WKY rats from 4–19 weeks of age, at 0–15 weeks treatment period. SBP and HR of treated SHR and its controls (A and B, respectively). SBP and HR of treated WKY rats and its controls (C and D, respectively). Each point represents mean±SEM (n = 6). Two-way ANOVA was used for statistical comparisons between the different treated groups and their strain-matched controls on the SBP and HR changes over the whole duration of treatment. ***p<0.001, compared with SHR controls; ###p<0.001, compared with RPO; @p<0.05, compared with PO.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3569425&req=5

pone-0055908-g001: Time course of effect of oil supplementation on systolic blood pressure and heart rate.The graphs show the effect of super olein (SO), red palm olein (RPO) and palm olein (PO) supplemented diets on the systolic blood pressure (SBP) and heart rate (HR) in SHR and WKY rats from 4–19 weeks of age, at 0–15 weeks treatment period. SBP and HR of treated SHR and its controls (A and B, respectively). SBP and HR of treated WKY rats and its controls (C and D, respectively). Each point represents mean±SEM (n = 6). Two-way ANOVA was used for statistical comparisons between the different treated groups and their strain-matched controls on the SBP and HR changes over the whole duration of treatment. ***p<0.001, compared with SHR controls; ###p<0.001, compared with RPO; @p<0.05, compared with PO.
Mentions: The SO, RPO and PO markedly attenuated the rise in BP in the SHR over the whole duration of treatment (Fig. 1A). The SBP of SHR was significantly lower following treatments with SO (F1,15 = 42.38, p<0.001), RPO (F1,15 = 18.22, p<0.001) and PO (F1,15 = 29.80, p<0.001) compared with SHR controls, when the whole duration of treatment was assessed by two-way ANOVA. Meanwhile, the HR of SO treated SHR (F1,15 = 3.119, p<0.001), but not the PO (F1,15 = 0.0722) or RPO treated SHR (F1,15 = 0.1054), was significantly reduced compared with SHR controls (two-way ANOVA; Fig. 1B).

Bottom Line: The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter.Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

ABSTRACT

Background: Oleic acid has been shown to lower high blood pressure and provide cardiovascular protection. Curiosity arises as to whether super olein (SO), red palm olein (RPO) and palm olein (PO), which have high oleic acid content, are able to prevent the development of hypertension.

Methodology/principal findings: Four-week-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were fed 15% SO, RPO or PO supplemented diet for 15 weeks. After 15 weeks of treatment, the systolic blood pressure (SBP) of SHR treated with SO, RPO and PO were 158.4±5.0 mmHg (p<0.001), 178.9±2.7 mmHg (p<0.001) and 167.7±2.1 mmHg (p<0.001), respectively, compared with SHR controls (220.9±1.5 mmHg). Bradycardia was observed with SO and PO. In contrast, the SBP and heart rate of treated WKY rats were not different from those of WKY controls. The SO and PO significantly reduced the increased heart size and thoracic aortic media thickness observed in untreated SHR but RPO reduced only the latter. No such differences, however, were observed between the treated and untreated WKY rats. Oil Red O enface staining of thoracic-abdominal aorta did not show any lipid deposition in all treated rats. The SO and RPO significantly raised serum alkaline phosphatase levels in the SHR while body weight and renal biochemical indices were unaltered in both strains. Serum lipid profiles of treated SHR and WKY rats were unchanged, with the exception of a significant reduction in LDL-C level and total cholesterol/HDL ratio (atherogenic index) in SO and RPO treated SHR compared with untreated SHR.

Conclusion: The SO, RPO and PO attenuate the rise in blood pressure in SHR, accompanied by bradycardia and heart size reduction with SO and PO, and aortic media thickness reduction with SO, RPO and PO. The SO and RPO are antiatherogenic in nature by improving blood lipid profiles in SHR.

Show MeSH
Related in: MedlinePlus