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(1SR,3RS,3aSR,6aRS)-Methyl 5-methyl-4,6-dioxo-3-[2-(trifluoro-meth-yl)phen-yl]octa-hydro-pyrrolo-[3,4-c]pyrrole-1-carboxyl-ate.

Kudryavtsev KV, Ivantcova PM, Churakov AV - Acta Crystallogr Sect E Struct Rep Online (2013)

Bottom Line: In the title compound, C(16)H(15)F(3)N(2)O(4), the relative stereochemistry of the four stereogenic C atoms has been determined.The carb-oxy-methyl and 2-(trifluoro-meth-yl)-phenyl substituents of the pyrrolidine cycle have a cis mutual arrangement.The five-membered saturated aza-cycle adopts an envelope conformation with the N atom occupying the flap position.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russian Federation ; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, Moscow Region, Russian Federation.

ABSTRACT
In the title compound, C(16)H(15)F(3)N(2)O(4), the relative stereochemistry of the four stereogenic C atoms has been determined. The carb-oxy-methyl and 2-(trifluoro-meth-yl)-phenyl substituents of the pyrrolidine cycle have a cis mutual arrangement. The five-membered saturated aza-cycle adopts an envelope conformation with the N atom occupying the flap position. In the crystal, adjacent mol-ecules are combined in centrosymmetric dimers by two weak N-H⋯O hydrogen bonds.

No MeSH data available.


Hydrogen-bonded dimers in the structure of the title compound. H-bonds are shown as dashed lines. [Symmetry code: (i) 1 - x, 2 - y, 1 - z.]
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Fap3: Hydrogen-bonded dimers in the structure of the title compound. H-bonds are shown as dashed lines. [Symmetry code: (i) 1 - x, 2 - y, 1 - z.]


(1SR,3RS,3aSR,6aRS)-Methyl 5-methyl-4,6-dioxo-3-[2-(trifluoro-meth-yl)phen-yl]octa-hydro-pyrrolo-[3,4-c]pyrrole-1-carboxyl-ate.

Kudryavtsev KV, Ivantcova PM, Churakov AV - Acta Crystallogr Sect E Struct Rep Online (2013)

Hydrogen-bonded dimers in the structure of the title compound. H-bonds are shown as dashed lines. [Symmetry code: (i) 1 - x, 2 - y, 1 - z.]
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569227&req=5

Fap3: Hydrogen-bonded dimers in the structure of the title compound. H-bonds are shown as dashed lines. [Symmetry code: (i) 1 - x, 2 - y, 1 - z.]
Bottom Line: In the title compound, C(16)H(15)F(3)N(2)O(4), the relative stereochemistry of the four stereogenic C atoms has been determined.The carb-oxy-methyl and 2-(trifluoro-meth-yl)-phenyl substituents of the pyrrolidine cycle have a cis mutual arrangement.The five-membered saturated aza-cycle adopts an envelope conformation with the N atom occupying the flap position.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russian Federation ; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, Moscow Region, Russian Federation.

ABSTRACT
In the title compound, C(16)H(15)F(3)N(2)O(4), the relative stereochemistry of the four stereogenic C atoms has been determined. The carb-oxy-methyl and 2-(trifluoro-meth-yl)-phenyl substituents of the pyrrolidine cycle have a cis mutual arrangement. The five-membered saturated aza-cycle adopts an envelope conformation with the N atom occupying the flap position. In the crystal, adjacent mol-ecules are combined in centrosymmetric dimers by two weak N-H⋯O hydrogen bonds.

No MeSH data available.