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Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects.

Watanabe SY, Iga J, Numata S, Nakataki M, Tanahashi T, Itakura M, Ohmori T - Clin Psychopharmacol Neurosci (2012)

Bottom Line: No significant difference in BMI was observed among any medications.We observed no significant difference in rs9939609 allele frequencies between patients and healthy subjects.We also observed a significant positive correlation between the number of risk allele (A allele) and BMI in healthy subjects.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Course of Integrated Brain Sciences, University of Tokushima School of Medicine, Tokushima, Japan.

ABSTRACT

Objective: Fat-mass and obesity-associated (FTO) gene is known to be involved in the pathophysiology of obesity and a single-nucleotide polymorphism (SNP) rs9939609 of FTO gene is repeatedly confirmed to be associated with body mass index (BMI) and obesity. The aim of this study is to elucidate effects of FTO gene polymorphism on BMI in Japanese patients with schizophrenia and healthy subjects.

Methods: Three hundred fifty one patients with schizophrenia and 342 age- and sex-matched healthy subjects participated in the study. Information on BMI and antipsychotic medication was also collected from patients and healthy subjects. Genotype of the FTO SNP rs9939609 was determined by TaqMan SNP Genotyping Assays.

Results: There was no significant difference in BMI between patients and healthy subjects. No significant difference in BMI was observed among any medications. We observed no significant difference in rs9939609 allele frequencies between patients and healthy subjects. There was a significant difference in BMI between healthy subjects with risk (AA or TA) genotypes and those with TT genotype. We also observed a significant positive correlation between the number of risk allele (A allele) and BMI in healthy subjects.

Conclusion: Our study suggested that FTO rs9939609 polymorphism might have some impacts on the BMI in healthy subjects, but might not have same impacts on the BMI of patients with schizophrenia.

No MeSH data available.


Related in: MedlinePlus

There was no significant difference in body mass index (BMI) between the carriers of TT genotype and those of AA/AT genotype in schizophrenia (p=0.851). SD, standard deviation.
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Figure 4: There was no significant difference in body mass index (BMI) between the carriers of TT genotype and those of AA/AT genotype in schizophrenia (p=0.851). SD, standard deviation.

Mentions: There was a significant difference in BMI between the carriers of AA/AT genotype and the carriers of TT genotype in healthy subjects. The carriers of AA/AT genotype had significant higher BMI than those of TT genotype in healthy subjects (Fig. 2) and a significant positive correlation was observed between the number of A allele and BMI in healthy subjects (Fig. 3). However, there was no significant difference in BMI between the carriers of AA/AT genotypes and those of TT genotype in patients (Fig. 4).


Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects.

Watanabe SY, Iga J, Numata S, Nakataki M, Tanahashi T, Itakura M, Ohmori T - Clin Psychopharmacol Neurosci (2012)

There was no significant difference in body mass index (BMI) between the carriers of TT genotype and those of AA/AT genotype in schizophrenia (p=0.851). SD, standard deviation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569167&req=5

Figure 4: There was no significant difference in body mass index (BMI) between the carriers of TT genotype and those of AA/AT genotype in schizophrenia (p=0.851). SD, standard deviation.
Mentions: There was a significant difference in BMI between the carriers of AA/AT genotype and the carriers of TT genotype in healthy subjects. The carriers of AA/AT genotype had significant higher BMI than those of TT genotype in healthy subjects (Fig. 2) and a significant positive correlation was observed between the number of A allele and BMI in healthy subjects (Fig. 3). However, there was no significant difference in BMI between the carriers of AA/AT genotypes and those of TT genotype in patients (Fig. 4).

Bottom Line: No significant difference in BMI was observed among any medications.We observed no significant difference in rs9939609 allele frequencies between patients and healthy subjects.We also observed a significant positive correlation between the number of risk allele (A allele) and BMI in healthy subjects.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Course of Integrated Brain Sciences, University of Tokushima School of Medicine, Tokushima, Japan.

ABSTRACT

Objective: Fat-mass and obesity-associated (FTO) gene is known to be involved in the pathophysiology of obesity and a single-nucleotide polymorphism (SNP) rs9939609 of FTO gene is repeatedly confirmed to be associated with body mass index (BMI) and obesity. The aim of this study is to elucidate effects of FTO gene polymorphism on BMI in Japanese patients with schizophrenia and healthy subjects.

Methods: Three hundred fifty one patients with schizophrenia and 342 age- and sex-matched healthy subjects participated in the study. Information on BMI and antipsychotic medication was also collected from patients and healthy subjects. Genotype of the FTO SNP rs9939609 was determined by TaqMan SNP Genotyping Assays.

Results: There was no significant difference in BMI between patients and healthy subjects. No significant difference in BMI was observed among any medications. We observed no significant difference in rs9939609 allele frequencies between patients and healthy subjects. There was a significant difference in BMI between healthy subjects with risk (AA or TA) genotypes and those with TT genotype. We also observed a significant positive correlation between the number of risk allele (A allele) and BMI in healthy subjects.

Conclusion: Our study suggested that FTO rs9939609 polymorphism might have some impacts on the BMI in healthy subjects, but might not have same impacts on the BMI of patients with schizophrenia.

No MeSH data available.


Related in: MedlinePlus