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Effects of chronic mild stress in female bax inhibitor-1-gene knockout mice.

Sui ZY, Chae HJ, Huang GB, Zhao T, Shrestha Muna S, Chung YC - Clin Psychopharmacol Neurosci (2012)

Bottom Line: Significant decreases in sucrose consumption and increases in immobility time in the FST were observed in both stress groups compared with the non-stress groups.These results suggest that BI-1 may play role in protecting against the depressogenic effects of CMS in the short term, but not in the long term.Further study is required to deepen understanding of the role of BI-1 in protecting against depression.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Chonbuk National University Medical School & Institute for Medical Sciences, Jeonju, Korea. ; Department of Psychiatry, Chonbuk National University Hospital & Research Institute of Clinical Medicine, Jeonju, Korea.

ABSTRACT

Objective: The anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to endoplasmic reticulum (ER) stress, and BI-1(-/-) mice exhibit increased sensitivity to tissue damage. The purpose of this study was to investigate the role of BI-1 in the pathogenesis of chronic mild stress (CMS)-induced depression-like behaviors in BI-1(-/-) mice.

Methods: We delivered CMS for 2 or 6 weeks in BI-1-knockout and wild-type mice. Control groups of BI-1-knockout and wild-type mice were left undisturbed. The measured parameters were sucrose consumption at weeks 1, 2, 3, 4, 5, and 6, spontaneous locomotion, and a forced swimming test (FST) at weeks 2 and 6.

Results: Significant decreases in sucrose consumption and increases in immobility time in the FST were observed in both stress groups compared with the non-stress groups. Interestingly, at week 2, but not at week 6, BI-1(-/-)-stress mice showed less sucrose intake and greater immobility time than did BI-1(+/+)-stress mice.

Conclusion: These results suggest that BI-1 may play role in protecting against the depressogenic effects of CMS in the short term, but not in the long term. Further study is required to deepen understanding of the role of BI-1 in protecting against depression.

No MeSH data available.


Related in: MedlinePlus

Body weight of four experimental groups during 6-week treatment of chronic mild stress. BI-1, Bax inhibitor-1.
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Figure 2: Body weight of four experimental groups during 6-week treatment of chronic mild stress. BI-1, Bax inhibitor-1.

Mentions: No significant difference in the main effect of group (F[3,17]=1.373, p=0.285), but significant differences in the main effect of time (F[6,102]=6.480, p<0.001) and a groupĂ—time interaction (F[18,102]=2.652, p=0.001) were observed for body weight (Fig. 2). Further analyses comparing the baseline and 6-week values among the groups revealed no significant differences.


Effects of chronic mild stress in female bax inhibitor-1-gene knockout mice.

Sui ZY, Chae HJ, Huang GB, Zhao T, Shrestha Muna S, Chung YC - Clin Psychopharmacol Neurosci (2012)

Body weight of four experimental groups during 6-week treatment of chronic mild stress. BI-1, Bax inhibitor-1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569165&req=5

Figure 2: Body weight of four experimental groups during 6-week treatment of chronic mild stress. BI-1, Bax inhibitor-1.
Mentions: No significant difference in the main effect of group (F[3,17]=1.373, p=0.285), but significant differences in the main effect of time (F[6,102]=6.480, p<0.001) and a groupĂ—time interaction (F[18,102]=2.652, p=0.001) were observed for body weight (Fig. 2). Further analyses comparing the baseline and 6-week values among the groups revealed no significant differences.

Bottom Line: Significant decreases in sucrose consumption and increases in immobility time in the FST were observed in both stress groups compared with the non-stress groups.These results suggest that BI-1 may play role in protecting against the depressogenic effects of CMS in the short term, but not in the long term.Further study is required to deepen understanding of the role of BI-1 in protecting against depression.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Chonbuk National University Medical School & Institute for Medical Sciences, Jeonju, Korea. ; Department of Psychiatry, Chonbuk National University Hospital & Research Institute of Clinical Medicine, Jeonju, Korea.

ABSTRACT

Objective: The anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to endoplasmic reticulum (ER) stress, and BI-1(-/-) mice exhibit increased sensitivity to tissue damage. The purpose of this study was to investigate the role of BI-1 in the pathogenesis of chronic mild stress (CMS)-induced depression-like behaviors in BI-1(-/-) mice.

Methods: We delivered CMS for 2 or 6 weeks in BI-1-knockout and wild-type mice. Control groups of BI-1-knockout and wild-type mice were left undisturbed. The measured parameters were sucrose consumption at weeks 1, 2, 3, 4, 5, and 6, spontaneous locomotion, and a forced swimming test (FST) at weeks 2 and 6.

Results: Significant decreases in sucrose consumption and increases in immobility time in the FST were observed in both stress groups compared with the non-stress groups. Interestingly, at week 2, but not at week 6, BI-1(-/-)-stress mice showed less sucrose intake and greater immobility time than did BI-1(+/+)-stress mice.

Conclusion: These results suggest that BI-1 may play role in protecting against the depressogenic effects of CMS in the short term, but not in the long term. Further study is required to deepen understanding of the role of BI-1 in protecting against depression.

No MeSH data available.


Related in: MedlinePlus