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Diffusion tensor imaging findings of white matter changes in first episode schizophrenia: a systematic review.

Kuswanto CN, Teh I, Lee TS, Sim K - Clin Psychopharmacol Neurosci (2012)

Bottom Line: Overall, disruptions of white matter integrity were found in the cortical, subcortical brain regions and white matter associative and commissural tracts, suggesting that changes of cortical-subcortical white matter integrity were found at an early stage of the disorder.These changes in white matter integrity were correlated with specific cognitive deficits (verbal and spatial working memory) as well as psychopathology (positive more than negative symptoms) in patients with FES.Future studies need to validate these findings in larger samples of subjects and in different populations as well as chart the progress of these cerebral white matter changes over time so as to better appreciate their trajectory with illness course, treatment and chronicity.

View Article: PubMed Central - PubMed

Affiliation: Institute of Mental Health/Woodbridge Hospital, Singapore.

ABSTRACT
Earlier structural magnetic resonance imaging in schizophrenia have noted smaller white matter volumes in diverse brain regions and recent diffusion tensor imaging (DTI) studies have allowed better elucidation of changes in brain white matter integrity within the illness. As white matter abnormalities have been reported to occur early in the course of schizophrenia, we systematically review extant DTI studies of anomalies of white matter integrity in first episode schizophrenia (FES) up till October 2011. Overall, disruptions of white matter integrity were found in the cortical, subcortical brain regions and white matter associative and commissural tracts, suggesting that changes of cortical-subcortical white matter integrity were found at an early stage of the disorder. These changes in white matter integrity were correlated with specific cognitive deficits (verbal and spatial working memory) as well as psychopathology (positive more than negative symptoms) in patients with FES. The correlation of these white matter integrity changes with cognitive and phenomenological factors may shed light on neurobiological substrates underlying these clinical manifestations. Future studies need to validate these findings in larger samples of subjects and in different populations as well as chart the progress of these cerebral white matter changes over time so as to better appreciate their trajectory with illness course, treatment and chronicity.

No MeSH data available.


Related in: MedlinePlus

Major brain regions implicated in first episode schizophrenia (FES) based on diffusion tensor imaging studies. A parasagittal section of the cerebrum shows the major brain regions and white matter tracts, i.e., temporal lobe (highlighted dark grey), occipital lobe (highlighted light grey), corpus callosum, inferior (straight lines) and superior longitudinal fasciculi (dotted lines) that have been shown to exhibit white matter abnormalities in FES.
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Figure 1: Major brain regions implicated in first episode schizophrenia (FES) based on diffusion tensor imaging studies. A parasagittal section of the cerebrum shows the major brain regions and white matter tracts, i.e., temporal lobe (highlighted dark grey), occipital lobe (highlighted light grey), corpus callosum, inferior (straight lines) and superior longitudinal fasciculi (dotted lines) that have been shown to exhibit white matter abnormalities in FES.

Mentions: Overall, we reviewed twenty-two studies that haveadopted DTI to study white matter abnormalities in FES(Table 1). The findings are grouped into white matter pathologyaffecting cortical, subcortical and white matter tracts(Table 2) and further summarised into a figure (Fig. 1).


Diffusion tensor imaging findings of white matter changes in first episode schizophrenia: a systematic review.

Kuswanto CN, Teh I, Lee TS, Sim K - Clin Psychopharmacol Neurosci (2012)

Major brain regions implicated in first episode schizophrenia (FES) based on diffusion tensor imaging studies. A parasagittal section of the cerebrum shows the major brain regions and white matter tracts, i.e., temporal lobe (highlighted dark grey), occipital lobe (highlighted light grey), corpus callosum, inferior (straight lines) and superior longitudinal fasciculi (dotted lines) that have been shown to exhibit white matter abnormalities in FES.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569158&req=5

Figure 1: Major brain regions implicated in first episode schizophrenia (FES) based on diffusion tensor imaging studies. A parasagittal section of the cerebrum shows the major brain regions and white matter tracts, i.e., temporal lobe (highlighted dark grey), occipital lobe (highlighted light grey), corpus callosum, inferior (straight lines) and superior longitudinal fasciculi (dotted lines) that have been shown to exhibit white matter abnormalities in FES.
Mentions: Overall, we reviewed twenty-two studies that haveadopted DTI to study white matter abnormalities in FES(Table 1). The findings are grouped into white matter pathologyaffecting cortical, subcortical and white matter tracts(Table 2) and further summarised into a figure (Fig. 1).

Bottom Line: Overall, disruptions of white matter integrity were found in the cortical, subcortical brain regions and white matter associative and commissural tracts, suggesting that changes of cortical-subcortical white matter integrity were found at an early stage of the disorder.These changes in white matter integrity were correlated with specific cognitive deficits (verbal and spatial working memory) as well as psychopathology (positive more than negative symptoms) in patients with FES.Future studies need to validate these findings in larger samples of subjects and in different populations as well as chart the progress of these cerebral white matter changes over time so as to better appreciate their trajectory with illness course, treatment and chronicity.

View Article: PubMed Central - PubMed

Affiliation: Institute of Mental Health/Woodbridge Hospital, Singapore.

ABSTRACT
Earlier structural magnetic resonance imaging in schizophrenia have noted smaller white matter volumes in diverse brain regions and recent diffusion tensor imaging (DTI) studies have allowed better elucidation of changes in brain white matter integrity within the illness. As white matter abnormalities have been reported to occur early in the course of schizophrenia, we systematically review extant DTI studies of anomalies of white matter integrity in first episode schizophrenia (FES) up till October 2011. Overall, disruptions of white matter integrity were found in the cortical, subcortical brain regions and white matter associative and commissural tracts, suggesting that changes of cortical-subcortical white matter integrity were found at an early stage of the disorder. These changes in white matter integrity were correlated with specific cognitive deficits (verbal and spatial working memory) as well as psychopathology (positive more than negative symptoms) in patients with FES. The correlation of these white matter integrity changes with cognitive and phenomenological factors may shed light on neurobiological substrates underlying these clinical manifestations. Future studies need to validate these findings in larger samples of subjects and in different populations as well as chart the progress of these cerebral white matter changes over time so as to better appreciate their trajectory with illness course, treatment and chronicity.

No MeSH data available.


Related in: MedlinePlus