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Effects of Psychotropic Drugs on Quantitative EEG among Patients with Schizophrenia-spectrum Disorders.

Hyun J, Baik MJ, Kang UG - Clin Psychopharmacol Neurosci (2011)

Bottom Line: However, we found no evident changes in power due to benzodiazepine.Our results are generally consistent with previous pharmaco-EEG studies, despite some differences.Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.

ABSTRACT

Objective: We examined how psychotropic medications affected quantitative EEG (qEEG) results among patients with a schizophrenia-spectrum disorder.

Methods: The drugs were clustered into nine groups depending on their mechanism. We hypothesized that drugs would affect the relative power shown in qEEG results independently and investigated the effect of each drug group on relative power using multiple linear regression analysis and independent samples t-tests.

Results: We found that antipsychotics other than clozapine induced an increase in the relative power of alpha activity. Clozapine markedly increased slow waves and decreased alpha activity in the occipital area. The main findings for antidepressants and antiepileptic drugs were the beta increment and lithium increased the power of delta and theta activity. However, we found no evident changes in power due to benzodiazepine.

Conclusion: Our results are generally consistent with previous pharmaco-EEG studies, despite some differences. Therefore, the EEG effect in each drug group could be singled out even under the polypharmacy condition, with the possible exception of benzodiazepines. Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

No MeSH data available.


Related in: MedlinePlus

Relative power changes induced by clozapine in group AP. AP, antipsychotics other than clozapine.
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Figure 3: Relative power changes induced by clozapine in group AP. AP, antipsychotics other than clozapine.

Mentions: We conducted an additional analysis for clozapine. Because the correlation analysis revealed a significant correlation between groups CLZ and AP (Table 3), we needed to perform an analysis after controlling for this confounding factor. Therefore, we investigated mean differences in relative power between the clozapine use (N=32) and non-use groups (N=106) within group AP (N=138) using a t-test. The significant increase in delta and theta relative power associated with administration of clozapine persisted after the use of other antipsychotics was controlled, as did the decreased alpha activity in the occipital area (Fig. 3). However, the decreased beta activity was less apparent than in the results of the preceding analysis, suggesting that the decrease was probably induced by the confounders.


Effects of Psychotropic Drugs on Quantitative EEG among Patients with Schizophrenia-spectrum Disorders.

Hyun J, Baik MJ, Kang UG - Clin Psychopharmacol Neurosci (2011)

Relative power changes induced by clozapine in group AP. AP, antipsychotics other than clozapine.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569080&req=5

Figure 3: Relative power changes induced by clozapine in group AP. AP, antipsychotics other than clozapine.
Mentions: We conducted an additional analysis for clozapine. Because the correlation analysis revealed a significant correlation between groups CLZ and AP (Table 3), we needed to perform an analysis after controlling for this confounding factor. Therefore, we investigated mean differences in relative power between the clozapine use (N=32) and non-use groups (N=106) within group AP (N=138) using a t-test. The significant increase in delta and theta relative power associated with administration of clozapine persisted after the use of other antipsychotics was controlled, as did the decreased alpha activity in the occipital area (Fig. 3). However, the decreased beta activity was less apparent than in the results of the preceding analysis, suggesting that the decrease was probably induced by the confounders.

Bottom Line: However, we found no evident changes in power due to benzodiazepine.Our results are generally consistent with previous pharmaco-EEG studies, despite some differences.Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.

ABSTRACT

Objective: We examined how psychotropic medications affected quantitative EEG (qEEG) results among patients with a schizophrenia-spectrum disorder.

Methods: The drugs were clustered into nine groups depending on their mechanism. We hypothesized that drugs would affect the relative power shown in qEEG results independently and investigated the effect of each drug group on relative power using multiple linear regression analysis and independent samples t-tests.

Results: We found that antipsychotics other than clozapine induced an increase in the relative power of alpha activity. Clozapine markedly increased slow waves and decreased alpha activity in the occipital area. The main findings for antidepressants and antiepileptic drugs were the beta increment and lithium increased the power of delta and theta activity. However, we found no evident changes in power due to benzodiazepine.

Conclusion: Our results are generally consistent with previous pharmaco-EEG studies, despite some differences. Therefore, the EEG effect in each drug group could be singled out even under the polypharmacy condition, with the possible exception of benzodiazepines. Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

No MeSH data available.


Related in: MedlinePlus