Limits...
Effects of Psychotropic Drugs on Quantitative EEG among Patients with Schizophrenia-spectrum Disorders.

Hyun J, Baik MJ, Kang UG - Clin Psychopharmacol Neurosci (2011)

Bottom Line: However, we found no evident changes in power due to benzodiazepine.Our results are generally consistent with previous pharmaco-EEG studies, despite some differences.Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.

ABSTRACT

Objective: We examined how psychotropic medications affected quantitative EEG (qEEG) results among patients with a schizophrenia-spectrum disorder.

Methods: The drugs were clustered into nine groups depending on their mechanism. We hypothesized that drugs would affect the relative power shown in qEEG results independently and investigated the effect of each drug group on relative power using multiple linear regression analysis and independent samples t-tests.

Results: We found that antipsychotics other than clozapine induced an increase in the relative power of alpha activity. Clozapine markedly increased slow waves and decreased alpha activity in the occipital area. The main findings for antidepressants and antiepileptic drugs were the beta increment and lithium increased the power of delta and theta activity. However, we found no evident changes in power due to benzodiazepine.

Conclusion: Our results are generally consistent with previous pharmaco-EEG studies, despite some differences. Therefore, the EEG effect in each drug group could be singled out even under the polypharmacy condition, with the possible exception of benzodiazepines. Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

No MeSH data available.


Related in: MedlinePlus

Statistical probability maps according to independent samples t-tests. AP, antipsychotics other than clozapine; CLZ, clozapine; AD, antidepressants; AED, antiepileptic drugs; Li, Lithium; BDZ, benzodiazepines.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3569080&req=5

Figure 2: Statistical probability maps according to independent samples t-tests. AP, antipsychotics other than clozapine; CLZ, clozapine; AD, antidepressants; AED, antiepileptic drugs; Li, Lithium; BDZ, benzodiazepines.

Mentions: Fig. 2 presents the results of independent sample t-tests. Similar to the results of the linear regression, we observed an increase in alpha relative power in group AP, but this increase was more evident than in the linear regression results. Increased delta and theta activity were still pronounced in group CLZ, with similar findings of decreased alpha activity (relatively limited to the occipital area) and decreased beta activity. We also found increased beta relative power in groups AD and AED. This analysis also revealed an increase in slow-wave activity in the lithium group, but the increase was less significant than in the linear regression results. In summary, the results of complementary t-tests were very consistent with linear regression analysis results, despite a few discrepancies such as the increased slow wave activity in some leads in group BDZ.


Effects of Psychotropic Drugs on Quantitative EEG among Patients with Schizophrenia-spectrum Disorders.

Hyun J, Baik MJ, Kang UG - Clin Psychopharmacol Neurosci (2011)

Statistical probability maps according to independent samples t-tests. AP, antipsychotics other than clozapine; CLZ, clozapine; AD, antidepressants; AED, antiepileptic drugs; Li, Lithium; BDZ, benzodiazepines.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569080&req=5

Figure 2: Statistical probability maps according to independent samples t-tests. AP, antipsychotics other than clozapine; CLZ, clozapine; AD, antidepressants; AED, antiepileptic drugs; Li, Lithium; BDZ, benzodiazepines.
Mentions: Fig. 2 presents the results of independent sample t-tests. Similar to the results of the linear regression, we observed an increase in alpha relative power in group AP, but this increase was more evident than in the linear regression results. Increased delta and theta activity were still pronounced in group CLZ, with similar findings of decreased alpha activity (relatively limited to the occipital area) and decreased beta activity. We also found increased beta relative power in groups AD and AED. This analysis also revealed an increase in slow-wave activity in the lithium group, but the increase was less significant than in the linear regression results. In summary, the results of complementary t-tests were very consistent with linear regression analysis results, despite a few discrepancies such as the increased slow wave activity in some leads in group BDZ.

Bottom Line: However, we found no evident changes in power due to benzodiazepine.Our results are generally consistent with previous pharmaco-EEG studies, despite some differences.Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.

ABSTRACT

Objective: We examined how psychotropic medications affected quantitative EEG (qEEG) results among patients with a schizophrenia-spectrum disorder.

Methods: The drugs were clustered into nine groups depending on their mechanism. We hypothesized that drugs would affect the relative power shown in qEEG results independently and investigated the effect of each drug group on relative power using multiple linear regression analysis and independent samples t-tests.

Results: We found that antipsychotics other than clozapine induced an increase in the relative power of alpha activity. Clozapine markedly increased slow waves and decreased alpha activity in the occipital area. The main findings for antidepressants and antiepileptic drugs were the beta increment and lithium increased the power of delta and theta activity. However, we found no evident changes in power due to benzodiazepine.

Conclusion: Our results are generally consistent with previous pharmaco-EEG studies, despite some differences. Therefore, the EEG effect in each drug group could be singled out even under the polypharmacy condition, with the possible exception of benzodiazepines. Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

No MeSH data available.


Related in: MedlinePlus