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Effects of Psychotropic Drugs on Quantitative EEG among Patients with Schizophrenia-spectrum Disorders.

Hyun J, Baik MJ, Kang UG - Clin Psychopharmacol Neurosci (2011)

Bottom Line: However, we found no evident changes in power due to benzodiazepine.Our results are generally consistent with previous pharmaco-EEG studies, despite some differences.Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.

ABSTRACT

Objective: We examined how psychotropic medications affected quantitative EEG (qEEG) results among patients with a schizophrenia-spectrum disorder.

Methods: The drugs were clustered into nine groups depending on their mechanism. We hypothesized that drugs would affect the relative power shown in qEEG results independently and investigated the effect of each drug group on relative power using multiple linear regression analysis and independent samples t-tests.

Results: We found that antipsychotics other than clozapine induced an increase in the relative power of alpha activity. Clozapine markedly increased slow waves and decreased alpha activity in the occipital area. The main findings for antidepressants and antiepileptic drugs were the beta increment and lithium increased the power of delta and theta activity. However, we found no evident changes in power due to benzodiazepine.

Conclusion: Our results are generally consistent with previous pharmaco-EEG studies, despite some differences. Therefore, the EEG effect in each drug group could be singled out even under the polypharmacy condition, with the possible exception of benzodiazepines. Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

No MeSH data available.


Related in: MedlinePlus

Statistical probability maps according to multiple regression analysis. AP, antipsychotics other than clozapine; CLZ, clozapine; AD, antidepressants; AED, antiepileptic drugs; Li, Lithium; BDZ, benzodiazepines.
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Figure 1: Statistical probability maps according to multiple regression analysis. AP, antipsychotics other than clozapine; CLZ, clozapine; AD, antidepressants; AED, antiepileptic drugs; Li, Lithium; BDZ, benzodiazepines.

Mentions: Fig. 1 presents statistical probability maps based on multiple regression analysis. Increased alpha relative power was observed for group AP but it was not clear in some leads (T5, P3, P4). Clozapine markedly increased slow waves, especially theta, and decreased beta in several leads. A topographical difference in alpha relative power appeared between temporal and occipital areas. Increased beta activity was the main finding for group AD, and increased delta activity was detected in a few leads (F7, T3). An increase in beta power was also observed in group AED; several EEG leads exhibited increased delta activity, and one lead (Cz) exhibited a decrease in alpha activity. The lithium group exhibited a clear increase in the relative power of delta and theta activity, but we did not detect any evident changes in group BDZ except for a solitary increase in alpha activity in T3.


Effects of Psychotropic Drugs on Quantitative EEG among Patients with Schizophrenia-spectrum Disorders.

Hyun J, Baik MJ, Kang UG - Clin Psychopharmacol Neurosci (2011)

Statistical probability maps according to multiple regression analysis. AP, antipsychotics other than clozapine; CLZ, clozapine; AD, antidepressants; AED, antiepileptic drugs; Li, Lithium; BDZ, benzodiazepines.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3569080&req=5

Figure 1: Statistical probability maps according to multiple regression analysis. AP, antipsychotics other than clozapine; CLZ, clozapine; AD, antidepressants; AED, antiepileptic drugs; Li, Lithium; BDZ, benzodiazepines.
Mentions: Fig. 1 presents statistical probability maps based on multiple regression analysis. Increased alpha relative power was observed for group AP but it was not clear in some leads (T5, P3, P4). Clozapine markedly increased slow waves, especially theta, and decreased beta in several leads. A topographical difference in alpha relative power appeared between temporal and occipital areas. Increased beta activity was the main finding for group AD, and increased delta activity was detected in a few leads (F7, T3). An increase in beta power was also observed in group AED; several EEG leads exhibited increased delta activity, and one lead (Cz) exhibited a decrease in alpha activity. The lithium group exhibited a clear increase in the relative power of delta and theta activity, but we did not detect any evident changes in group BDZ except for a solitary increase in alpha activity in T3.

Bottom Line: However, we found no evident changes in power due to benzodiazepine.Our results are generally consistent with previous pharmaco-EEG studies, despite some differences.Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.

ABSTRACT

Objective: We examined how psychotropic medications affected quantitative EEG (qEEG) results among patients with a schizophrenia-spectrum disorder.

Methods: The drugs were clustered into nine groups depending on their mechanism. We hypothesized that drugs would affect the relative power shown in qEEG results independently and investigated the effect of each drug group on relative power using multiple linear regression analysis and independent samples t-tests.

Results: We found that antipsychotics other than clozapine induced an increase in the relative power of alpha activity. Clozapine markedly increased slow waves and decreased alpha activity in the occipital area. The main findings for antidepressants and antiepileptic drugs were the beta increment and lithium increased the power of delta and theta activity. However, we found no evident changes in power due to benzodiazepine.

Conclusion: Our results are generally consistent with previous pharmaco-EEG studies, despite some differences. Therefore, the EEG effect in each drug group could be singled out even under the polypharmacy condition, with the possible exception of benzodiazepines. Our results support using a new methodological approach to identify the qEEG effects of various psychotropic drugs in clinical settings.

No MeSH data available.


Related in: MedlinePlus