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Burden of illness associated with painful diabetic peripheral neuropathy among adults seeking treatment in the US: results from a retrospective chart review and cross-sectional survey.

Sadosky A, Schaefer C, Mann R, Bergstrom F, Baik R, Parsons B, Nalamachu S, Nieshoff E, Stacey BR, Anschel A, Tuchman M - Diabetes Metab Syndr Obes (2013)

Bottom Line: Subjects with pDPN exhibited high pain levels, which were associated with poor sleep, function, and productivity.Health care resource utilization in pDPN was prevalent and costs increased with greater pain severity.The burden of pDPN was greater among subjects with greater pain severity.

View Article: PubMed Central - PubMed

Affiliation: Pfizer Inc, New York, N Y.

ABSTRACT

Background: The purpose of this study was to characterize the burden of illness among adult subjects with painful diabetic peripheral neuropathy (pDPN) seeking treatment in the US.

Methods: This observational study recruited 112 subjects with pDPN during routine visits from general practitioner and specialist sites. Subjects completed a one-time questionnaire, which included demographics, symptom duration, health care resource use, out-of-pocket costs, employment status, and validated measures that assessed pain, functioning, sleep, anxiety and depression, health status, and productivity. Investigators completed a case report form based on a 6-month retrospective chart review to capture clinical information, pDPN-related treatments, and other pDPN-related health care resource use over the past 6 months. Annualized costs were extrapolated based on reported 6-month health care resource use.

Results: The mean age of the subjects was 61.1 years, 52.7% were female, and 17.9% were in paid employment. The most common comorbid conditions were sleep disturbance/insomnia (43.8%), depressive symptoms (41.1%), and anxiety (35.7%). The mean pain severity score was 5.2 (0-10 scale), and 79.5% reported moderate or severe pain. The mean pain interference with function score was 5.0 (0-10 scale) overall, with 2.0 among mild, 5.1 among moderate, and 7.0 among severe. The mean Medical Outcomes Study sleep problems index score was 48.5 (0-100 scale). The mean health state utility score was 0.61. Among subjects employed for pay, mean overall work impairment was 43.6%. Across all subjects, mean overall activity impairment was 52.3%. In total, 81.3% were prescribed at least one medication for their pDPN; 50.9% reported taking at least one nonprescription medication. Adjusted mean annualized total direct and indirect costs per subject were $4841 and $9730, respectively. Outcomes related to pain interference with function, sleep, health status, activity impairment, prescription medication use, and direct and indirect costs were significantly worse among subjects with more severe pain (P < 0.0020).

Conclusion: Subjects with pDPN exhibited high pain levels, which were associated with poor sleep, function, and productivity. Health care resource utilization in pDPN was prevalent and costs increased with greater pain severity. The burden of pDPN was greater among subjects with greater pain severity.

No MeSH data available.


Related in: MedlinePlus

SF-12 physical and mental component summary scores, overall and by average pain severity.*Notes: *Scores on the BPI Pain Severity were used to classify average pain severity as follows: 0–3 represents mild pain, 4–6 represents moderate pain, and 7–10 represents severe pain; †P < 0.0001 for both PCS and MCS. All domains [physical function, role physical, bodily pain, general health, vitality, social functioning, role emotional, mental health] including PCS and MCS significantly different by average pain severity (P < 0.001).
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f2A-dmso-6-079: SF-12 physical and mental component summary scores, overall and by average pain severity.*Notes: *Scores on the BPI Pain Severity were used to classify average pain severity as follows: 0–3 represents mild pain, 4–6 represents moderate pain, and 7–10 represents severe pain; †P < 0.0001 for both PCS and MCS. All domains [physical function, role physical, bodily pain, general health, vitality, social functioning, role emotional, mental health] including PCS and MCS significantly different by average pain severity (P < 0.001).

Mentions: The mean Physical Component Summary and Mental Component Summary scores were 32.2 ± 10.1 and 44.0 ± 12.1, respectively (Figure 2A). Across all SF-12 domains, including both summary scores, higher pain severity was associated with lower health status (P < 0.0007, Table 2). Using the EQ-5D, the mean health utility score overall was 0.61 ± 0.22 (Table 2). Health utility scores also decreased significantly as pain severity increased (mild, 0.80 ± 0.13; moderate, 0.66 ± 0.17; and severe, 0.39 ± 0.18; P < 0.0001, Table 2).


Burden of illness associated with painful diabetic peripheral neuropathy among adults seeking treatment in the US: results from a retrospective chart review and cross-sectional survey.

Sadosky A, Schaefer C, Mann R, Bergstrom F, Baik R, Parsons B, Nalamachu S, Nieshoff E, Stacey BR, Anschel A, Tuchman M - Diabetes Metab Syndr Obes (2013)

SF-12 physical and mental component summary scores, overall and by average pain severity.*Notes: *Scores on the BPI Pain Severity were used to classify average pain severity as follows: 0–3 represents mild pain, 4–6 represents moderate pain, and 7–10 represents severe pain; †P < 0.0001 for both PCS and MCS. All domains [physical function, role physical, bodily pain, general health, vitality, social functioning, role emotional, mental health] including PCS and MCS significantly different by average pain severity (P < 0.001).
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3569051&req=5

f2A-dmso-6-079: SF-12 physical and mental component summary scores, overall and by average pain severity.*Notes: *Scores on the BPI Pain Severity were used to classify average pain severity as follows: 0–3 represents mild pain, 4–6 represents moderate pain, and 7–10 represents severe pain; †P < 0.0001 for both PCS and MCS. All domains [physical function, role physical, bodily pain, general health, vitality, social functioning, role emotional, mental health] including PCS and MCS significantly different by average pain severity (P < 0.001).
Mentions: The mean Physical Component Summary and Mental Component Summary scores were 32.2 ± 10.1 and 44.0 ± 12.1, respectively (Figure 2A). Across all SF-12 domains, including both summary scores, higher pain severity was associated with lower health status (P < 0.0007, Table 2). Using the EQ-5D, the mean health utility score overall was 0.61 ± 0.22 (Table 2). Health utility scores also decreased significantly as pain severity increased (mild, 0.80 ± 0.13; moderate, 0.66 ± 0.17; and severe, 0.39 ± 0.18; P < 0.0001, Table 2).

Bottom Line: Subjects with pDPN exhibited high pain levels, which were associated with poor sleep, function, and productivity.Health care resource utilization in pDPN was prevalent and costs increased with greater pain severity.The burden of pDPN was greater among subjects with greater pain severity.

View Article: PubMed Central - PubMed

Affiliation: Pfizer Inc, New York, N Y.

ABSTRACT

Background: The purpose of this study was to characterize the burden of illness among adult subjects with painful diabetic peripheral neuropathy (pDPN) seeking treatment in the US.

Methods: This observational study recruited 112 subjects with pDPN during routine visits from general practitioner and specialist sites. Subjects completed a one-time questionnaire, which included demographics, symptom duration, health care resource use, out-of-pocket costs, employment status, and validated measures that assessed pain, functioning, sleep, anxiety and depression, health status, and productivity. Investigators completed a case report form based on a 6-month retrospective chart review to capture clinical information, pDPN-related treatments, and other pDPN-related health care resource use over the past 6 months. Annualized costs were extrapolated based on reported 6-month health care resource use.

Results: The mean age of the subjects was 61.1 years, 52.7% were female, and 17.9% were in paid employment. The most common comorbid conditions were sleep disturbance/insomnia (43.8%), depressive symptoms (41.1%), and anxiety (35.7%). The mean pain severity score was 5.2 (0-10 scale), and 79.5% reported moderate or severe pain. The mean pain interference with function score was 5.0 (0-10 scale) overall, with 2.0 among mild, 5.1 among moderate, and 7.0 among severe. The mean Medical Outcomes Study sleep problems index score was 48.5 (0-100 scale). The mean health state utility score was 0.61. Among subjects employed for pay, mean overall work impairment was 43.6%. Across all subjects, mean overall activity impairment was 52.3%. In total, 81.3% were prescribed at least one medication for their pDPN; 50.9% reported taking at least one nonprescription medication. Adjusted mean annualized total direct and indirect costs per subject were $4841 and $9730, respectively. Outcomes related to pain interference with function, sleep, health status, activity impairment, prescription medication use, and direct and indirect costs were significantly worse among subjects with more severe pain (P < 0.0020).

Conclusion: Subjects with pDPN exhibited high pain levels, which were associated with poor sleep, function, and productivity. Health care resource utilization in pDPN was prevalent and costs increased with greater pain severity. The burden of pDPN was greater among subjects with greater pain severity.

No MeSH data available.


Related in: MedlinePlus