Limits...
The neural basis of nonvisual object recognition memory in the rat.

Albasser MM, Olarte-Sánchez CM, Amin E, Horne MR, Newton MJ, Warburton EC, Aggleton JP - Behav. Neurosci. (2012)

Bottom Line: The hippocampal findings prompted Experiment 2.Across two replications, no evidence was found that hippocampal lesions impair nonvisual object recognition.These findings reveal a network of linked c-fos activations that share superficial features with those associated with visual recognition but differ in the fine details; for example, in the locus of the perirhinal cortex activation.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, Cardiff University, Cardiff, Wales, UK.

Show MeSH

Related in: MedlinePlus

Coronal sections illustrating the hippocampal lesions in those cases in Cohort 1 and 2 with the smallest (dark gray) and largest (light gray) region of cell loss. The numbers refer to the approximate distance of each section in mm caudal to bregma. From The Rat Brain in Stereotaxic Coordinates (figures 26, 29, 31, 33, 35, 37, 39, 41, 43, 45) by G. Paxinos and C. Watson, 1997
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3569044&req=5

fig5: Coronal sections illustrating the hippocampal lesions in those cases in Cohort 1 and 2 with the smallest (dark gray) and largest (light gray) region of cell loss. The numbers refer to the approximate distance of each section in mm caudal to bregma. From The Rat Brain in Stereotaxic Coordinates (figures 26, 29, 31, 33, 35, 37, 39, 41, 43, 45) by G. Paxinos and C. Watson, 1997

Mentions: Cohort 1: Figure 5 depicts a series of coronal sections (based on Paxinos & Watson, 2005) showing the maximum and minimum extent of hippocampal damage. Histological analyses revealed that four rats had appreciable sparing of the hippocampus (less than 50% volume loss), and all four rats were excluded from the behavioral analyses. The remaining 18 HpcC1 rats had extensive damage to the hippocampus that was typically more complete in the dorsal rather than the ventral hippocampus. Three rats had over 85% volume loss of the dorsal hippocampus, with eight more rats having more than 70% damage to the dorsal hippocampus. In these rats the only consistent sparing was restricted to the most medial part of the dorsal hippocampus, in particular the most medial part of the blade of the dentate gyrus. The remaining seven rats had from 50% to 70% cell loss in the dorsal hippocampus, with most sparing of the medial parts of the dorsal hippocampus.


The neural basis of nonvisual object recognition memory in the rat.

Albasser MM, Olarte-Sánchez CM, Amin E, Horne MR, Newton MJ, Warburton EC, Aggleton JP - Behav. Neurosci. (2012)

Coronal sections illustrating the hippocampal lesions in those cases in Cohort 1 and 2 with the smallest (dark gray) and largest (light gray) region of cell loss. The numbers refer to the approximate distance of each section in mm caudal to bregma. From The Rat Brain in Stereotaxic Coordinates (figures 26, 29, 31, 33, 35, 37, 39, 41, 43, 45) by G. Paxinos and C. Watson, 1997
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3569044&req=5

fig5: Coronal sections illustrating the hippocampal lesions in those cases in Cohort 1 and 2 with the smallest (dark gray) and largest (light gray) region of cell loss. The numbers refer to the approximate distance of each section in mm caudal to bregma. From The Rat Brain in Stereotaxic Coordinates (figures 26, 29, 31, 33, 35, 37, 39, 41, 43, 45) by G. Paxinos and C. Watson, 1997
Mentions: Cohort 1: Figure 5 depicts a series of coronal sections (based on Paxinos & Watson, 2005) showing the maximum and minimum extent of hippocampal damage. Histological analyses revealed that four rats had appreciable sparing of the hippocampus (less than 50% volume loss), and all four rats were excluded from the behavioral analyses. The remaining 18 HpcC1 rats had extensive damage to the hippocampus that was typically more complete in the dorsal rather than the ventral hippocampus. Three rats had over 85% volume loss of the dorsal hippocampus, with eight more rats having more than 70% damage to the dorsal hippocampus. In these rats the only consistent sparing was restricted to the most medial part of the dorsal hippocampus, in particular the most medial part of the blade of the dentate gyrus. The remaining seven rats had from 50% to 70% cell loss in the dorsal hippocampus, with most sparing of the medial parts of the dorsal hippocampus.

Bottom Line: The hippocampal findings prompted Experiment 2.Across two replications, no evidence was found that hippocampal lesions impair nonvisual object recognition.These findings reveal a network of linked c-fos activations that share superficial features with those associated with visual recognition but differ in the fine details; for example, in the locus of the perirhinal cortex activation.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, Cardiff University, Cardiff, Wales, UK.

Show MeSH
Related in: MedlinePlus