The neural basis of nonvisual object recognition memory in the rat.
Bottom Line: The hippocampal findings prompted Experiment 2.Across two replications, no evidence was found that hippocampal lesions impair nonvisual object recognition.These findings reveal a network of linked c-fos activations that share superficial features with those associated with visual recognition but differ in the fine details; for example, in the locus of the perirhinal cortex activation.
Affiliation: School of Psychology, Cardiff University, Cardiff, Wales, UK.Show MeSH
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Mentions: While exposure to novel objects (Group Novel vs. Group Familiar) did not produce a significant overall increase in Fos-positive cells across these areas, F(1, 14) = 3.24, p = .094 (Figure 4, lower left), there were significantly different patterns of c-fos activity within the perirhinal cortex (group by subregion interaction: F(6, 84) = 4.37, p < .001) reflecting selective responses to novel stimuli. Simple effects found a significant increase of Fos-positive cells in rostral perirhinal areas 35 and 36, rostral area 35, F(1, 98) = 12.6, p < .001; rostral area 36, F(1, 98) = 12.6, p < .001). In both sites these changes were supported by the results of a matched t test based on the raw scores, rostral area 35 t(7) = 2.24, p = .031; rostral area 36 t(7) = 1.93, p = .048, one-tailed. In none of the other sites did the simple effects indicate a significant change, mid area 35, F < 1, mid area 36, F < 1; caudal area 35, F(1, 98) = 2.70, p = .10; caudal area 36, F < 1; area Te2, F(1, 98) = 1.25, p = .27.
Affiliation: School of Psychology, Cardiff University, Cardiff, Wales, UK.