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The neural basis of nonvisual object recognition memory in the rat.

Albasser MM, Olarte-Sánchez CM, Amin E, Horne MR, Newton MJ, Warburton EC, Aggleton JP - Behav. Neurosci. (2012)

Bottom Line: The hippocampal findings prompted Experiment 2.Across two replications, no evidence was found that hippocampal lesions impair nonvisual object recognition.These findings reveal a network of linked c-fos activations that share superficial features with those associated with visual recognition but differ in the fine details; for example, in the locus of the perirhinal cortex activation.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, Cardiff University, Cardiff, Wales, UK.

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Histograms showing the normalized Fos counts for Group Novel (dark) and Group Familiar (light) for the seven grouped regions of interest. Because the data are normalized they sum to 100. Abbreviations: AC = anterior cingulate cortex; AD = anterior dorsal thalamic nucleus; AM = anterior medial thalamic nucleus; Audp = primary auditory cortex; AV = anterior ventral thalamic nucleus; DG = dentate gyrus; dSub = dorsal subiculum; Hpc = hippocampus; I = infralimbic cortex; lEnt = lateral entorhinal cortex; MD = medial dorsal thalamic nucleus; mEnt = medial entorhinal cortex; PL = prelimbic cortex; Perirhinal cortex (r = rostral; m = mid; c = caudal, areas 35 and 36); PPC = posterior parietal cortex; Rdg = retrosplenial dysgranular cortex; Rga = retrosplenial granular a; Rgb = retrosplenial granular b; SS = somatosensory cortex; Te2 = cortical area Te2; Visp = primary visual cortex; vSub = ventral subiculum. * p < 0.05, ** p < 0.01, *** p < 0.001 (simple effects).
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fig4: Histograms showing the normalized Fos counts for Group Novel (dark) and Group Familiar (light) for the seven grouped regions of interest. Because the data are normalized they sum to 100. Abbreviations: AC = anterior cingulate cortex; AD = anterior dorsal thalamic nucleus; AM = anterior medial thalamic nucleus; Audp = primary auditory cortex; AV = anterior ventral thalamic nucleus; DG = dentate gyrus; dSub = dorsal subiculum; Hpc = hippocampus; I = infralimbic cortex; lEnt = lateral entorhinal cortex; MD = medial dorsal thalamic nucleus; mEnt = medial entorhinal cortex; PL = prelimbic cortex; Perirhinal cortex (r = rostral; m = mid; c = caudal, areas 35 and 36); PPC = posterior parietal cortex; Rdg = retrosplenial dysgranular cortex; Rga = retrosplenial granular a; Rgb = retrosplenial granular b; SS = somatosensory cortex; Te2 = cortical area Te2; Visp = primary visual cortex; vSub = ventral subiculum. * p < 0.05, ** p < 0.01, *** p < 0.001 (simple effects).

Mentions: While exposure to novel objects (Group Novel vs. Group Familiar) did not produce a significant overall increase in Fos-positive cells across these areas, F(1, 14) = 3.24, p = .094 (Figure 4, lower left), there were significantly different patterns of c-fos activity within the perirhinal cortex (group by subregion interaction: F(6, 84) = 4.37, p < .001) reflecting selective responses to novel stimuli. Simple effects found a significant increase of Fos-positive cells in rostral perirhinal areas 35 and 36, rostral area 35, F(1, 98) = 12.6, p < .001; rostral area 36, F(1, 98) = 12.6, p < .001). In both sites these changes were supported by the results of a matched t test based on the raw scores, rostral area 35 t(7) = 2.24, p = .031; rostral area 36 t(7) = 1.93, p = .048, one-tailed. In none of the other sites did the simple effects indicate a significant change, mid area 35, F < 1, mid area 36, F < 1; caudal area 35, F(1, 98) = 2.70, p = .10; caudal area 36, F < 1; area Te2, F(1, 98) = 1.25, p = .27.


The neural basis of nonvisual object recognition memory in the rat.

Albasser MM, Olarte-Sánchez CM, Amin E, Horne MR, Newton MJ, Warburton EC, Aggleton JP - Behav. Neurosci. (2012)

Histograms showing the normalized Fos counts for Group Novel (dark) and Group Familiar (light) for the seven grouped regions of interest. Because the data are normalized they sum to 100. Abbreviations: AC = anterior cingulate cortex; AD = anterior dorsal thalamic nucleus; AM = anterior medial thalamic nucleus; Audp = primary auditory cortex; AV = anterior ventral thalamic nucleus; DG = dentate gyrus; dSub = dorsal subiculum; Hpc = hippocampus; I = infralimbic cortex; lEnt = lateral entorhinal cortex; MD = medial dorsal thalamic nucleus; mEnt = medial entorhinal cortex; PL = prelimbic cortex; Perirhinal cortex (r = rostral; m = mid; c = caudal, areas 35 and 36); PPC = posterior parietal cortex; Rdg = retrosplenial dysgranular cortex; Rga = retrosplenial granular a; Rgb = retrosplenial granular b; SS = somatosensory cortex; Te2 = cortical area Te2; Visp = primary visual cortex; vSub = ventral subiculum. * p < 0.05, ** p < 0.01, *** p < 0.001 (simple effects).
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Related In: Results  -  Collection

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fig4: Histograms showing the normalized Fos counts for Group Novel (dark) and Group Familiar (light) for the seven grouped regions of interest. Because the data are normalized they sum to 100. Abbreviations: AC = anterior cingulate cortex; AD = anterior dorsal thalamic nucleus; AM = anterior medial thalamic nucleus; Audp = primary auditory cortex; AV = anterior ventral thalamic nucleus; DG = dentate gyrus; dSub = dorsal subiculum; Hpc = hippocampus; I = infralimbic cortex; lEnt = lateral entorhinal cortex; MD = medial dorsal thalamic nucleus; mEnt = medial entorhinal cortex; PL = prelimbic cortex; Perirhinal cortex (r = rostral; m = mid; c = caudal, areas 35 and 36); PPC = posterior parietal cortex; Rdg = retrosplenial dysgranular cortex; Rga = retrosplenial granular a; Rgb = retrosplenial granular b; SS = somatosensory cortex; Te2 = cortical area Te2; Visp = primary visual cortex; vSub = ventral subiculum. * p < 0.05, ** p < 0.01, *** p < 0.001 (simple effects).
Mentions: While exposure to novel objects (Group Novel vs. Group Familiar) did not produce a significant overall increase in Fos-positive cells across these areas, F(1, 14) = 3.24, p = .094 (Figure 4, lower left), there were significantly different patterns of c-fos activity within the perirhinal cortex (group by subregion interaction: F(6, 84) = 4.37, p < .001) reflecting selective responses to novel stimuli. Simple effects found a significant increase of Fos-positive cells in rostral perirhinal areas 35 and 36, rostral area 35, F(1, 98) = 12.6, p < .001; rostral area 36, F(1, 98) = 12.6, p < .001). In both sites these changes were supported by the results of a matched t test based on the raw scores, rostral area 35 t(7) = 2.24, p = .031; rostral area 36 t(7) = 1.93, p = .048, one-tailed. In none of the other sites did the simple effects indicate a significant change, mid area 35, F < 1, mid area 36, F < 1; caudal area 35, F(1, 98) = 2.70, p = .10; caudal area 36, F < 1; area Te2, F(1, 98) = 1.25, p = .27.

Bottom Line: The hippocampal findings prompted Experiment 2.Across two replications, no evidence was found that hippocampal lesions impair nonvisual object recognition.These findings reveal a network of linked c-fos activations that share superficial features with those associated with visual recognition but differ in the fine details; for example, in the locus of the perirhinal cortex activation.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, Cardiff University, Cardiff, Wales, UK.

Show MeSH
Related in: MedlinePlus