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The neural basis of nonvisual object recognition memory in the rat.

Albasser MM, Olarte-Sánchez CM, Amin E, Horne MR, Newton MJ, Warburton EC, Aggleton JP - Behav. Neurosci. (2012)

Bottom Line: The hippocampal findings prompted Experiment 2.Across two replications, no evidence was found that hippocampal lesions impair nonvisual object recognition.These findings reveal a network of linked c-fos activations that share superficial features with those associated with visual recognition but differ in the fine details; for example, in the locus of the perirhinal cortex activation.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, Cardiff University, Cardiff, Wales, UK.

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Related in: MedlinePlus

Coronal sections indicating the regions of interest. Abbreviations: AC = anterior cingulate cortex; Audp = primary auditory cortex; DG = dentate gyrus; dSub = dorsal subiculum; Hpc = hippocampus; IL = infralimbic cortex; lEnt = lateral entorhinal cortex; mEnt = medial entorhinal cortex; PL = prelimbic cortex; Prh = perirhinal cortex; Rdg = retrosplenial dysgranular cortex; Rga = retrosplenial granular; Rgb = retrosplenial granular; Te2 = cortical area Te2; Visp = primary visual cortex; vSub = ventral subiculum. The numbers refer to the distance (mm) from bregma. From The Rat Brain in Stereotaxic Coordinates (figures 12, 31, 54, 56, 65, 73, 74 and 84) by G. Paxinos and C. Watson, 2005
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fig2: Coronal sections indicating the regions of interest. Abbreviations: AC = anterior cingulate cortex; Audp = primary auditory cortex; DG = dentate gyrus; dSub = dorsal subiculum; Hpc = hippocampus; IL = infralimbic cortex; lEnt = lateral entorhinal cortex; mEnt = medial entorhinal cortex; PL = prelimbic cortex; Prh = perirhinal cortex; Rdg = retrosplenial dysgranular cortex; Rga = retrosplenial granular; Rgb = retrosplenial granular; Te2 = cortical area Te2; Visp = primary visual cortex; vSub = ventral subiculum. The numbers refer to the distance (mm) from bregma. From The Rat Brain in Stereotaxic Coordinates (figures 12, 31, 54, 56, 65, 73, 74 and 84) by G. Paxinos and C. Watson, 2005

Mentions: Numbers of labeled cells in each region of interest were determined by counting cells (mean feret, a measure of particle size, of 4–20 μm) stained above an automatically determined threshold of greyscale intensity that was above background levels (software setting for histogram intensity phases = 3). The cortical counts were made in a frame area of 0.84 × 0.63 mm that enabled all laminae to be included in one image. For the hippocampus, image montages of the dentate gyrus, CA3, and CA1 fields were created from coronal sections at the septal, intermediate and temporal levels of the hippocampus (see Figure 2). For all brain areas analyzed, counts were taken from four consecutive immunoreacted sections from each hemisphere. As a consequence, each section was separated by120 μm in the anterior-posterior (AP) plane as the tissue came from a one-in-three (40 μm) series.


The neural basis of nonvisual object recognition memory in the rat.

Albasser MM, Olarte-Sánchez CM, Amin E, Horne MR, Newton MJ, Warburton EC, Aggleton JP - Behav. Neurosci. (2012)

Coronal sections indicating the regions of interest. Abbreviations: AC = anterior cingulate cortex; Audp = primary auditory cortex; DG = dentate gyrus; dSub = dorsal subiculum; Hpc = hippocampus; IL = infralimbic cortex; lEnt = lateral entorhinal cortex; mEnt = medial entorhinal cortex; PL = prelimbic cortex; Prh = perirhinal cortex; Rdg = retrosplenial dysgranular cortex; Rga = retrosplenial granular; Rgb = retrosplenial granular; Te2 = cortical area Te2; Visp = primary visual cortex; vSub = ventral subiculum. The numbers refer to the distance (mm) from bregma. From The Rat Brain in Stereotaxic Coordinates (figures 12, 31, 54, 56, 65, 73, 74 and 84) by G. Paxinos and C. Watson, 2005
© Copyright Policy - open-access
Related In: Results  -  Collection

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fig2: Coronal sections indicating the regions of interest. Abbreviations: AC = anterior cingulate cortex; Audp = primary auditory cortex; DG = dentate gyrus; dSub = dorsal subiculum; Hpc = hippocampus; IL = infralimbic cortex; lEnt = lateral entorhinal cortex; mEnt = medial entorhinal cortex; PL = prelimbic cortex; Prh = perirhinal cortex; Rdg = retrosplenial dysgranular cortex; Rga = retrosplenial granular; Rgb = retrosplenial granular; Te2 = cortical area Te2; Visp = primary visual cortex; vSub = ventral subiculum. The numbers refer to the distance (mm) from bregma. From The Rat Brain in Stereotaxic Coordinates (figures 12, 31, 54, 56, 65, 73, 74 and 84) by G. Paxinos and C. Watson, 2005
Mentions: Numbers of labeled cells in each region of interest were determined by counting cells (mean feret, a measure of particle size, of 4–20 μm) stained above an automatically determined threshold of greyscale intensity that was above background levels (software setting for histogram intensity phases = 3). The cortical counts were made in a frame area of 0.84 × 0.63 mm that enabled all laminae to be included in one image. For the hippocampus, image montages of the dentate gyrus, CA3, and CA1 fields were created from coronal sections at the septal, intermediate and temporal levels of the hippocampus (see Figure 2). For all brain areas analyzed, counts were taken from four consecutive immunoreacted sections from each hemisphere. As a consequence, each section was separated by120 μm in the anterior-posterior (AP) plane as the tissue came from a one-in-three (40 μm) series.

Bottom Line: The hippocampal findings prompted Experiment 2.Across two replications, no evidence was found that hippocampal lesions impair nonvisual object recognition.These findings reveal a network of linked c-fos activations that share superficial features with those associated with visual recognition but differ in the fine details; for example, in the locus of the perirhinal cortex activation.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, Cardiff University, Cardiff, Wales, UK.

Show MeSH
Related in: MedlinePlus