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Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.

Coutu S, Rossi L, Barry DA, Rudaz S, Vernaz N - PLoS ONE (2013)

Bottom Line: Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached.This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs).Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected.

View Article: PubMed Central - PubMed

Affiliation: ENAC/IIE/ECOL, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. sylvain.coutu@epfl.ch

ABSTRACT
Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined temporal fluctuations (monthly time scale) in antibiotic sources (ambulatory sales and data from a hospital dispensary) for Lausanne, Switzerland. Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached. First, some substances--azithromycin, clarithromycin, ciprofloxacin--displayed high seasonality in their consumption, with the winter peak being up to three times higher than the summer minimum. This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs). In addition, the seasonality in PECs was also influenced by that in the base wastewater flow. Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected. That is, there was no connection between fluctuations in ambulatory and hospital consumption for the substances investigated.

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Related in: MedlinePlus

Ratio of hospital use to total use for the Lausanne WTP basin.Results are presented for clindamycin (green), trimethoprim (red) and ciprofloxacin (blue). This ratio shows considerable volatility, depending on the month and substance considered.
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pone-0053592-g005: Ratio of hospital use to total use for the Lausanne WTP basin.Results are presented for clindamycin (green), trimethoprim (red) and ciprofloxacin (blue). This ratio shows considerable volatility, depending on the month and substance considered.

Mentions: Previous studies that evaluated the proportion of hospital-sourced pharmaceuticals to the total WTP load typically used a fixed figure [34]–[37]. This figure was often obtained from comparison of measurements of hospital effluent and WTP influent. Recently, Le Corre et al. [27] suggested calculating this ratio from sales data, but the study is limited by the fact that authors could only provide annual data. Yet, figure 5 shows that monthly variability of this ratio can be significant.


Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.

Coutu S, Rossi L, Barry DA, Rudaz S, Vernaz N - PLoS ONE (2013)

Ratio of hospital use to total use for the Lausanne WTP basin.Results are presented for clindamycin (green), trimethoprim (red) and ciprofloxacin (blue). This ratio shows considerable volatility, depending on the month and substance considered.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539968&req=5

pone-0053592-g005: Ratio of hospital use to total use for the Lausanne WTP basin.Results are presented for clindamycin (green), trimethoprim (red) and ciprofloxacin (blue). This ratio shows considerable volatility, depending on the month and substance considered.
Mentions: Previous studies that evaluated the proportion of hospital-sourced pharmaceuticals to the total WTP load typically used a fixed figure [34]–[37]. This figure was often obtained from comparison of measurements of hospital effluent and WTP influent. Recently, Le Corre et al. [27] suggested calculating this ratio from sales data, but the study is limited by the fact that authors could only provide annual data. Yet, figure 5 shows that monthly variability of this ratio can be significant.

Bottom Line: Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached.This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs).Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected.

View Article: PubMed Central - PubMed

Affiliation: ENAC/IIE/ECOL, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. sylvain.coutu@epfl.ch

ABSTRACT
Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined temporal fluctuations (monthly time scale) in antibiotic sources (ambulatory sales and data from a hospital dispensary) for Lausanne, Switzerland. Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached. First, some substances--azithromycin, clarithromycin, ciprofloxacin--displayed high seasonality in their consumption, with the winter peak being up to three times higher than the summer minimum. This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs). In addition, the seasonality in PECs was also influenced by that in the base wastewater flow. Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected. That is, there was no connection between fluctuations in ambulatory and hospital consumption for the substances investigated.

Show MeSH
Related in: MedlinePlus