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Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.

Coutu S, Rossi L, Barry DA, Rudaz S, Vernaz N - PLoS ONE (2013)

Bottom Line: Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached.This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs).Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected.

View Article: PubMed Central - PubMed

Affiliation: ENAC/IIE/ECOL, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. sylvain.coutu@epfl.ch

ABSTRACT
Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined temporal fluctuations (monthly time scale) in antibiotic sources (ambulatory sales and data from a hospital dispensary) for Lausanne, Switzerland. Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached. First, some substances--azithromycin, clarithromycin, ciprofloxacin--displayed high seasonality in their consumption, with the winter peak being up to three times higher than the summer minimum. This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs). In addition, the seasonality in PECs was also influenced by that in the base wastewater flow. Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected. That is, there was no connection between fluctuations in ambulatory and hospital consumption for the substances investigated.

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Schematic view of the Vidy Bay WTP basin considered in this study.The main pipes of the collection system are illustrated with bold lines. Hospitals and clinics for acute somatic treatment are located using grey pentagons. The total number of hospital beds in the basin is about 1600, which corresponds to a total of approximately 8 beds per 1000 inhabitant.
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pone-0053592-g002: Schematic view of the Vidy Bay WTP basin considered in this study.The main pipes of the collection system are illustrated with bold lines. Hospitals and clinics for acute somatic treatment are located using grey pentagons. The total number of hospital beds in the basin is about 1600, which corresponds to a total of approximately 8 beds per 1000 inhabitant.

Mentions: In our approach, we considered only hospitals or clinics performing acute somatic treatments, as such establishments dispense antibiotic prescriptions. Ten hospitals were identified, for a total of 1600 beds. Their spatial distribution on the WTP basin is illustrated in Figure 2.


Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.

Coutu S, Rossi L, Barry DA, Rudaz S, Vernaz N - PLoS ONE (2013)

Schematic view of the Vidy Bay WTP basin considered in this study.The main pipes of the collection system are illustrated with bold lines. Hospitals and clinics for acute somatic treatment are located using grey pentagons. The total number of hospital beds in the basin is about 1600, which corresponds to a total of approximately 8 beds per 1000 inhabitant.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539968&req=5

pone-0053592-g002: Schematic view of the Vidy Bay WTP basin considered in this study.The main pipes of the collection system are illustrated with bold lines. Hospitals and clinics for acute somatic treatment are located using grey pentagons. The total number of hospital beds in the basin is about 1600, which corresponds to a total of approximately 8 beds per 1000 inhabitant.
Mentions: In our approach, we considered only hospitals or clinics performing acute somatic treatments, as such establishments dispense antibiotic prescriptions. Ten hospitals were identified, for a total of 1600 beds. Their spatial distribution on the WTP basin is illustrated in Figure 2.

Bottom Line: Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached.This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs).Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected.

View Article: PubMed Central - PubMed

Affiliation: ENAC/IIE/ECOL, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. sylvain.coutu@epfl.ch

ABSTRACT
Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined temporal fluctuations (monthly time scale) in antibiotic sources (ambulatory sales and data from a hospital dispensary) for Lausanne, Switzerland. Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached. First, some substances--azithromycin, clarithromycin, ciprofloxacin--displayed high seasonality in their consumption, with the winter peak being up to three times higher than the summer minimum. This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs). In addition, the seasonality in PECs was also influenced by that in the base wastewater flow. Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected. That is, there was no connection between fluctuations in ambulatory and hospital consumption for the substances investigated.

Show MeSH
Related in: MedlinePlus