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Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.

Coutu S, Rossi L, Barry DA, Rudaz S, Vernaz N - PLoS ONE (2013)

Bottom Line: Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached.This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs).Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected.

View Article: PubMed Central - PubMed

Affiliation: ENAC/IIE/ECOL, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. sylvain.coutu@epfl.ch

ABSTRACT
Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined temporal fluctuations (monthly time scale) in antibiotic sources (ambulatory sales and data from a hospital dispensary) for Lausanne, Switzerland. Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached. First, some substances--azithromycin, clarithromycin, ciprofloxacin--displayed high seasonality in their consumption, with the winter peak being up to three times higher than the summer minimum. This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs). In addition, the seasonality in PECs was also influenced by that in the base wastewater flow. Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected. That is, there was no connection between fluctuations in ambulatory and hospital consumption for the substances investigated.

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Related in: MedlinePlus

Monthly variations of dry weather flow at the Vidy Bay WTP inlet.Flow is normalized to the annual mean flow, which is  m3. The monthly baseflow fluctuates between +40/−25% of the mean.
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pone-0053592-g001: Monthly variations of dry weather flow at the Vidy Bay WTP inlet.Flow is normalized to the annual mean flow, which is m3. The monthly baseflow fluctuates between +40/−25% of the mean.

Mentions: The study was conducted on the main WTP catchment of Lausanne, Switzerland. This WTP serves 200′000 residents, and is located at Vidy Bay, on the shore of Lake Geneva. The annual total wastewater volume treated is approximately m3. The monthly water volume received at the WTP varies seasonally, as can be seen in Figure 1, which illustrates the dynamics of the monthly dry weather water volume at the Vidy Bay WTP inlet.


Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.

Coutu S, Rossi L, Barry DA, Rudaz S, Vernaz N - PLoS ONE (2013)

Monthly variations of dry weather flow at the Vidy Bay WTP inlet.Flow is normalized to the annual mean flow, which is  m3. The monthly baseflow fluctuates between +40/−25% of the mean.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539968&req=5

pone-0053592-g001: Monthly variations of dry weather flow at the Vidy Bay WTP inlet.Flow is normalized to the annual mean flow, which is m3. The monthly baseflow fluctuates between +40/−25% of the mean.
Mentions: The study was conducted on the main WTP catchment of Lausanne, Switzerland. This WTP serves 200′000 residents, and is located at Vidy Bay, on the shore of Lake Geneva. The annual total wastewater volume treated is approximately m3. The monthly water volume received at the WTP varies seasonally, as can be seen in Figure 1, which illustrates the dynamics of the monthly dry weather water volume at the Vidy Bay WTP inlet.

Bottom Line: Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached.This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs).Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected.

View Article: PubMed Central - PubMed

Affiliation: ENAC/IIE/ECOL, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. sylvain.coutu@epfl.ch

ABSTRACT
Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined temporal fluctuations (monthly time scale) in antibiotic sources (ambulatory sales and data from a hospital dispensary) for Lausanne, Switzerland. Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached. First, some substances--azithromycin, clarithromycin, ciprofloxacin--displayed high seasonality in their consumption, with the winter peak being up to three times higher than the summer minimum. This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs). In addition, the seasonality in PECs was also influenced by that in the base wastewater flow. Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected. That is, there was no connection between fluctuations in ambulatory and hospital consumption for the substances investigated.

Show MeSH
Related in: MedlinePlus