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Parotid small cell carcinoma presenting with long-term survival after surgery alone: a case report.

Kanazawa T, Fukushima N, Tanaka H, Shiba J, Nishino H, Mineta H, Ichimura K - J Med Case Rep (2012)

Bottom Line: However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration.Multidisciplinary therapy was usually required to achieve long-term survival.We present a locoregional advanced parotid small cell carcinoma with multiple lymph node metastases in an 87-year-old Asian woman.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Otolaryngology/Head and Neck Surgery, Jichi Medical University School of Medicine, 3311-1, Shimotsuke, 329-0498, Japan. kanatake@omiya.jichi.ac.jp.

ABSTRACT

Introduction: Primary involvement of the salivary glands in small cell carcinoma is rare, and has one of the worst prognoses of salivary gland neoplasms. However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration. Multidisciplinary therapy was usually required to achieve long-term survival. Recently, a resemblance of some small cell carcinomas of the salivary gland to cutaneous Merkel cell carcinoma was suggested; the latter have the potential for spontaneous regression, which is related to a favorable clinical outcome.

Case presentation: We present a locoregional advanced parotid small cell carcinoma with multiple lymph node metastases in an 87-year-old Asian woman. The tumor was controlled by surgery alone, and nine-year disease-free survival was achieved without any adjunctive therapy. To the best of our knowledge, this is the longest reported follow-up of head and neck small cell carcinoma.

Conclusion: We believe this to be the first case of small cell carcinoma with involvement of the salivary glands reported in the literature with a good outcome after surgery alone without any adjunctive therapy.

No MeSH data available.


Related in: MedlinePlus

Histological features. (A) Diffuse growth with necrosis (lower right) of tumor cells is seen. Several residual ducts and glands are observed in the tumor. (B) The tumor shares the features of small cell carcinomas seen in other organs. It is composed of small- to medium-sized epithelioid cells with hyperchromatic, finely granular nuclei and scant cytoplasm. Mitotic figures are frequently seen.
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Figure 2: Histological features. (A) Diffuse growth with necrosis (lower right) of tumor cells is seen. Several residual ducts and glands are observed in the tumor. (B) The tumor shares the features of small cell carcinomas seen in other organs. It is composed of small- to medium-sized epithelioid cells with hyperchromatic, finely granular nuclei and scant cytoplasm. Mitotic figures are frequently seen.

Mentions: FNA was performed again and a cytological examination revealed a Papanicolaou classification of Class V, suggesting SmCC. A total parotidectomy and modified neck dissection were performed. On histopathology, the tumor showed diffuse growth with confluent necrosis in the salivary gland. The tumor cells had scant cytoplasm and hyperchromatic nuclei without prominent nucleoli. Mitotic figures were frequently observed (Figure 2). Neoplasmic elements reveal positivity for cluster of differentiation 56, neuron specific enolase, synaptophysin and a dotted staining pattern with cytokeratin 20 (Figure 3). Based on our histopathological findings, a diagnosis of a Merkel-cell-like SmCC of the parotid gland was made. Additional studies were positive for Maspin.


Parotid small cell carcinoma presenting with long-term survival after surgery alone: a case report.

Kanazawa T, Fukushima N, Tanaka H, Shiba J, Nishino H, Mineta H, Ichimura K - J Med Case Rep (2012)

Histological features. (A) Diffuse growth with necrosis (lower right) of tumor cells is seen. Several residual ducts and glands are observed in the tumor. (B) The tumor shares the features of small cell carcinomas seen in other organs. It is composed of small- to medium-sized epithelioid cells with hyperchromatic, finely granular nuclei and scant cytoplasm. Mitotic figures are frequently seen.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539965&req=5

Figure 2: Histological features. (A) Diffuse growth with necrosis (lower right) of tumor cells is seen. Several residual ducts and glands are observed in the tumor. (B) The tumor shares the features of small cell carcinomas seen in other organs. It is composed of small- to medium-sized epithelioid cells with hyperchromatic, finely granular nuclei and scant cytoplasm. Mitotic figures are frequently seen.
Mentions: FNA was performed again and a cytological examination revealed a Papanicolaou classification of Class V, suggesting SmCC. A total parotidectomy and modified neck dissection were performed. On histopathology, the tumor showed diffuse growth with confluent necrosis in the salivary gland. The tumor cells had scant cytoplasm and hyperchromatic nuclei without prominent nucleoli. Mitotic figures were frequently observed (Figure 2). Neoplasmic elements reveal positivity for cluster of differentiation 56, neuron specific enolase, synaptophysin and a dotted staining pattern with cytokeratin 20 (Figure 3). Based on our histopathological findings, a diagnosis of a Merkel-cell-like SmCC of the parotid gland was made. Additional studies were positive for Maspin.

Bottom Line: However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration.Multidisciplinary therapy was usually required to achieve long-term survival.We present a locoregional advanced parotid small cell carcinoma with multiple lymph node metastases in an 87-year-old Asian woman.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Otolaryngology/Head and Neck Surgery, Jichi Medical University School of Medicine, 3311-1, Shimotsuke, 329-0498, Japan. kanatake@omiya.jichi.ac.jp.

ABSTRACT

Introduction: Primary involvement of the salivary glands in small cell carcinoma is rare, and has one of the worst prognoses of salivary gland neoplasms. However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration. Multidisciplinary therapy was usually required to achieve long-term survival. Recently, a resemblance of some small cell carcinomas of the salivary gland to cutaneous Merkel cell carcinoma was suggested; the latter have the potential for spontaneous regression, which is related to a favorable clinical outcome.

Case presentation: We present a locoregional advanced parotid small cell carcinoma with multiple lymph node metastases in an 87-year-old Asian woman. The tumor was controlled by surgery alone, and nine-year disease-free survival was achieved without any adjunctive therapy. To the best of our knowledge, this is the longest reported follow-up of head and neck small cell carcinoma.

Conclusion: We believe this to be the first case of small cell carcinoma with involvement of the salivary glands reported in the literature with a good outcome after surgery alone without any adjunctive therapy.

No MeSH data available.


Related in: MedlinePlus