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Parotid small cell carcinoma presenting with long-term survival after surgery alone: a case report.

Kanazawa T, Fukushima N, Tanaka H, Shiba J, Nishino H, Mineta H, Ichimura K - J Med Case Rep (2012)

Bottom Line: However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration.Multidisciplinary therapy was usually required to achieve long-term survival.We present a locoregional advanced parotid small cell carcinoma with multiple lymph node metastases in an 87-year-old Asian woman.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Otolaryngology/Head and Neck Surgery, Jichi Medical University School of Medicine, 3311-1, Shimotsuke, 329-0498, Japan. kanatake@omiya.jichi.ac.jp.

ABSTRACT

Introduction: Primary involvement of the salivary glands in small cell carcinoma is rare, and has one of the worst prognoses of salivary gland neoplasms. However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration. Multidisciplinary therapy was usually required to achieve long-term survival. Recently, a resemblance of some small cell carcinomas of the salivary gland to cutaneous Merkel cell carcinoma was suggested; the latter have the potential for spontaneous regression, which is related to a favorable clinical outcome.

Case presentation: We present a locoregional advanced parotid small cell carcinoma with multiple lymph node metastases in an 87-year-old Asian woman. The tumor was controlled by surgery alone, and nine-year disease-free survival was achieved without any adjunctive therapy. To the best of our knowledge, this is the longest reported follow-up of head and neck small cell carcinoma.

Conclusion: We believe this to be the first case of small cell carcinoma with involvement of the salivary glands reported in the literature with a good outcome after surgery alone without any adjunctive therapy.

No MeSH data available.


Related in: MedlinePlus

Magnetic resonance imaging scans. Magnetic resonance imaging shows this lesion to be clearly circumscribed, with (A) homogeneous hypo-iso signal intensity on T1-weighted images and (B) heterogeneous high signal intensity on T2-weighted images. (C) Axial and (D) coronal gadolinium-enhanced T1-weighted images show the presence of a circumscribed and heterogeneously enhanced tumor.
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Figure 1: Magnetic resonance imaging scans. Magnetic resonance imaging shows this lesion to be clearly circumscribed, with (A) homogeneous hypo-iso signal intensity on T1-weighted images and (B) heterogeneous high signal intensity on T2-weighted images. (C) Axial and (D) coronal gadolinium-enhanced T1-weighted images show the presence of a circumscribed and heterogeneously enhanced tumor.

Mentions: A physical examination revealed a 55-mm tumor located in the parotid with extension to the retroparotid area, and swelling of her left laterocervical lymph node. A computed tomography scan showed a peripheral enhanced mass in her right parotid gland. Magnetic resonance imaging revealed low signal intensity on T1-weighted images and iso-high signal intensity on T2-weighted images. The images showed the lesion to be clearly circumscribed, with homogeneous hypo-iso signal intensity on T1-weighted images and heterogeneous high signal intensity on T2-weighted images. The tumor demonstrated circumscribed and heterogeneous enhancement on gadolinium-enhanced T1-weighted images (Figure 1). Computed tomography scans of her thorax and abdomen did not reveal involvement of other sites.


Parotid small cell carcinoma presenting with long-term survival after surgery alone: a case report.

Kanazawa T, Fukushima N, Tanaka H, Shiba J, Nishino H, Mineta H, Ichimura K - J Med Case Rep (2012)

Magnetic resonance imaging scans. Magnetic resonance imaging shows this lesion to be clearly circumscribed, with (A) homogeneous hypo-iso signal intensity on T1-weighted images and (B) heterogeneous high signal intensity on T2-weighted images. (C) Axial and (D) coronal gadolinium-enhanced T1-weighted images show the presence of a circumscribed and heterogeneously enhanced tumor.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539965&req=5

Figure 1: Magnetic resonance imaging scans. Magnetic resonance imaging shows this lesion to be clearly circumscribed, with (A) homogeneous hypo-iso signal intensity on T1-weighted images and (B) heterogeneous high signal intensity on T2-weighted images. (C) Axial and (D) coronal gadolinium-enhanced T1-weighted images show the presence of a circumscribed and heterogeneously enhanced tumor.
Mentions: A physical examination revealed a 55-mm tumor located in the parotid with extension to the retroparotid area, and swelling of her left laterocervical lymph node. A computed tomography scan showed a peripheral enhanced mass in her right parotid gland. Magnetic resonance imaging revealed low signal intensity on T1-weighted images and iso-high signal intensity on T2-weighted images. The images showed the lesion to be clearly circumscribed, with homogeneous hypo-iso signal intensity on T1-weighted images and heterogeneous high signal intensity on T2-weighted images. The tumor demonstrated circumscribed and heterogeneous enhancement on gadolinium-enhanced T1-weighted images (Figure 1). Computed tomography scans of her thorax and abdomen did not reveal involvement of other sites.

Bottom Line: However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration.Multidisciplinary therapy was usually required to achieve long-term survival.We present a locoregional advanced parotid small cell carcinoma with multiple lymph node metastases in an 87-year-old Asian woman.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Otolaryngology/Head and Neck Surgery, Jichi Medical University School of Medicine, 3311-1, Shimotsuke, 329-0498, Japan. kanatake@omiya.jichi.ac.jp.

ABSTRACT

Introduction: Primary involvement of the salivary glands in small cell carcinoma is rare, and has one of the worst prognoses of salivary gland neoplasms. However, it has been reported that some cases have a favorable outcome, although the prognostic factors are still under consideration. Multidisciplinary therapy was usually required to achieve long-term survival. Recently, a resemblance of some small cell carcinomas of the salivary gland to cutaneous Merkel cell carcinoma was suggested; the latter have the potential for spontaneous regression, which is related to a favorable clinical outcome.

Case presentation: We present a locoregional advanced parotid small cell carcinoma with multiple lymph node metastases in an 87-year-old Asian woman. The tumor was controlled by surgery alone, and nine-year disease-free survival was achieved without any adjunctive therapy. To the best of our knowledge, this is the longest reported follow-up of head and neck small cell carcinoma.

Conclusion: We believe this to be the first case of small cell carcinoma with involvement of the salivary glands reported in the literature with a good outcome after surgery alone without any adjunctive therapy.

No MeSH data available.


Related in: MedlinePlus