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N-cadherin is differentially expressed in histological subtypes of papillary renal cell carcinoma.

Behnes CL, Hemmerlein B, Strauss A, Radzun HJ, Bremmer F - Diagn Pathol (2012)

Bottom Line: All papillary RCC type II displayed a membranous expression for N-cadherin, whereas type I did not show any membranous positivity for N-cadherin.E-cadherin exhibited a stronger, but not significant, membranous as well as cytoplasmic expression in type II than in type I papillary RCC.Thus N-cadherin represents the first immunhistochemical marker for a clear cut differentiation between papillary RCC type I and type II and could be a target for therapy and diagnostic in the future.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, University of Göttingen, Robert-Koch-Str 40, 37083 Göttingen, Germany. clbehnes@med.uni-goettingen.de

ABSTRACT

Background: Papillary renal cell carcinoma (RCC) represents a rare tumor, which is divided, based on histological criteria, into two subtypes. In contrast to type I papillary RCC type II papillary RCC shows a worse prognosis. So far, reliable immunohistochemical markers for the distinction of these subtypes are not available.

Methods: In the present study the expression of N(neural)-, E(epithelial)-, P(placental)-, and KSP(kidney specific)-cadherin was examined in 22 papillary RCC of histological type I and 18 papillary RCC of histological type II (n = 40).

Results: All papillary RCC type II displayed a membranous expression for N-cadherin, whereas type I did not show any membranous positivity for N-cadherin. E-cadherin exhibited a stronger, but not significant, membranous as well as cytoplasmic expression in type II than in type I papillary RCC. A diagnostic relevant expression of P- and KSP-cadherin could not be demonstrated in both tumor entities.

Conclusion: Thus N-cadherin represents the first immunhistochemical marker for a clear cut differentiation between papillary RCC type I and type II and could be a target for therapy and diagnostic in the future.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2011556982761733.

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Immunohistochemistry of E-, P-, KSP- and cadherin expression in papillary RCC. Expression of E- (A / D), P- (B / E) and KSP-cadherin (C / F) in papillary RCC type II (A, B, C x20) and type I (D, E, F x20). The expression patterns are not suitable for a clear cut differentiation of both tumor subtypes (for details see results).
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Figure 3: Immunohistochemistry of E-, P-, KSP- and cadherin expression in papillary RCC. Expression of E- (A / D), P- (B / E) and KSP-cadherin (C / F) in papillary RCC type II (A, B, C x20) and type I (D, E, F x20). The expression patterns are not suitable for a clear cut differentiation of both tumor subtypes (for details see results).

Mentions: The E-cadherin staining showed in the majority of papillary RCC type II a weak membranous (IRS 1.83 ± 2.72) as well as cytoplasmic expression (IRS 1.89 ± 2.49). In papillary RCC type I a decreased expression of membranous (IRS 1.28 ± 1.95) and an approximately similar cytoplasmic E-cadherin (IRS 1.81 ± 1.94) could be determined. A statistical comparison showed no significant difference for membranous as well as cytoplasmic E-cadherin expression in both subtypes of papillary RCC (p = n. s.) (Figure 3A, D and Figure 2).


N-cadherin is differentially expressed in histological subtypes of papillary renal cell carcinoma.

Behnes CL, Hemmerlein B, Strauss A, Radzun HJ, Bremmer F - Diagn Pathol (2012)

Immunohistochemistry of E-, P-, KSP- and cadherin expression in papillary RCC. Expression of E- (A / D), P- (B / E) and KSP-cadherin (C / F) in papillary RCC type II (A, B, C x20) and type I (D, E, F x20). The expression patterns are not suitable for a clear cut differentiation of both tumor subtypes (for details see results).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539962&req=5

Figure 3: Immunohistochemistry of E-, P-, KSP- and cadherin expression in papillary RCC. Expression of E- (A / D), P- (B / E) and KSP-cadherin (C / F) in papillary RCC type II (A, B, C x20) and type I (D, E, F x20). The expression patterns are not suitable for a clear cut differentiation of both tumor subtypes (for details see results).
Mentions: The E-cadherin staining showed in the majority of papillary RCC type II a weak membranous (IRS 1.83 ± 2.72) as well as cytoplasmic expression (IRS 1.89 ± 2.49). In papillary RCC type I a decreased expression of membranous (IRS 1.28 ± 1.95) and an approximately similar cytoplasmic E-cadherin (IRS 1.81 ± 1.94) could be determined. A statistical comparison showed no significant difference for membranous as well as cytoplasmic E-cadherin expression in both subtypes of papillary RCC (p = n. s.) (Figure 3A, D and Figure 2).

Bottom Line: All papillary RCC type II displayed a membranous expression for N-cadherin, whereas type I did not show any membranous positivity for N-cadherin.E-cadherin exhibited a stronger, but not significant, membranous as well as cytoplasmic expression in type II than in type I papillary RCC.Thus N-cadherin represents the first immunhistochemical marker for a clear cut differentiation between papillary RCC type I and type II and could be a target for therapy and diagnostic in the future.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, University of Göttingen, Robert-Koch-Str 40, 37083 Göttingen, Germany. clbehnes@med.uni-goettingen.de

ABSTRACT

Background: Papillary renal cell carcinoma (RCC) represents a rare tumor, which is divided, based on histological criteria, into two subtypes. In contrast to type I papillary RCC type II papillary RCC shows a worse prognosis. So far, reliable immunohistochemical markers for the distinction of these subtypes are not available.

Methods: In the present study the expression of N(neural)-, E(epithelial)-, P(placental)-, and KSP(kidney specific)-cadherin was examined in 22 papillary RCC of histological type I and 18 papillary RCC of histological type II (n = 40).

Results: All papillary RCC type II displayed a membranous expression for N-cadherin, whereas type I did not show any membranous positivity for N-cadherin. E-cadherin exhibited a stronger, but not significant, membranous as well as cytoplasmic expression in type II than in type I papillary RCC. A diagnostic relevant expression of P- and KSP-cadherin could not be demonstrated in both tumor entities.

Conclusion: Thus N-cadherin represents the first immunhistochemical marker for a clear cut differentiation between papillary RCC type I and type II and could be a target for therapy and diagnostic in the future.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2011556982761733.

Show MeSH
Related in: MedlinePlus