Limits...
LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL).

Mao Y, Zhang DW, Zhu H, Lin H, Xiong L, Cao Q, Liu Y, Li QD, Xu JR, Xu LF, Chen RJ - Diagn Pathol (2012)

Bottom Line: Latent membrane protein (LMP) 1 and LMP2A encoded by Epstein-Barr virus (EBV) are associated with the development of malignancies, but their expression in extranodal NK/T-cell lymphoma, nasal type (ENKTL) and the relationship with clinical characteristics of this disease remain poorly understood.High LMP1 expression was associated with positive B symptoms (p = 0.012), while high LMP2A expression was related to gender (p = 0.029).The expression of both LMP1 and LMP2A showed significant correlations with patients' overall survival (p = 0.049, p = 0.036).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Nanjing Medical University, No,121 Jiang jia yuan, Nanjing 210011, China.

ABSTRACT

Background: Latent membrane protein (LMP) 1 and LMP2A encoded by Epstein-Barr virus (EBV) are associated with the development of malignancies, but their expression in extranodal NK/T-cell lymphoma, nasal type (ENKTL) and the relationship with clinical characteristics of this disease remain poorly understood. In the present study, we examined the expression of LMP1 and LMP2A in ENKTL, and investigated the correlations between LMP1 and LMP2A expression with clinicopathological characteristics of ENKTL patients.

Methods: Paraffin sections of surgically removed samples from 16 ENKTL patients were analyzed by immunohistochemistry and the related clinicopathological data were collected and analyzed.

Results: Elevated expression (immunohistochemistry score ≥ 4) of LMP1 and LMP2A was detected in the tumor cells of ENKTL. High LMP1 expression was associated with positive B symptoms (p = 0.012), while high LMP2A expression was related to gender (p = 0.029). The expression of both LMP1 and LMP2A showed significant correlations with patients' overall survival (p = 0.049, p = 0.036).

Conclusion: LMP1 and LMP2A may be prognostic indicators of survival in patients with ENKTL.

Virtual slides: http://www.diagnosticpathology.diagnomx.eu/vs/2443352538545899.

Show MeSH

Related in: MedlinePlus

Analysis of the survival of ENKTL patients by Kaplan-Meier method. (A) Overall survival rate in patients with positive B symptoms (red line) was significantly lower than that in patients with negative B symptoms (green line). (B) Overall survival rate in patients with single therapy (red line) was significantly lower than that in patients with combined therapy (green line). (C) Overall survival rate in patients with positive LMP1 expression (red line) was significantly lower than that in patients with negative LMP1 expression (green line). (D) Overall survival rate in patients with positive LMP2A expression (red line) was significantly lower than that in patients with negative LMP2A expression (green line).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3539909&req=5

Figure 2: Analysis of the survival of ENKTL patients by Kaplan-Meier method. (A) Overall survival rate in patients with positive B symptoms (red line) was significantly lower than that in patients with negative B symptoms (green line). (B) Overall survival rate in patients with single therapy (red line) was significantly lower than that in patients with combined therapy (green line). (C) Overall survival rate in patients with positive LMP1 expression (red line) was significantly lower than that in patients with negative LMP1 expression (green line). (D) Overall survival rate in patients with positive LMP2A expression (red line) was significantly lower than that in patients with negative LMP2A expression (green line).

Mentions: Kaplan-Meier analysis of 16 ENKTL patients showed that the survival rate was significantly lower in patients with positive B symptoms, subjected to single therapy, or with high LMP1 and LMP2A expression. Log-rank test showed that positive B symptoms, treatment by single therapy, and high expression of LMP1 and LMP2A were associated with decreased overall survival of ENKTL patients (P = 0.0180, P = 0.0082, P = 0.0201, P = 0.0487) (Table 3, Figure 2).


LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL).

Mao Y, Zhang DW, Zhu H, Lin H, Xiong L, Cao Q, Liu Y, Li QD, Xu JR, Xu LF, Chen RJ - Diagn Pathol (2012)

Analysis of the survival of ENKTL patients by Kaplan-Meier method. (A) Overall survival rate in patients with positive B symptoms (red line) was significantly lower than that in patients with negative B symptoms (green line). (B) Overall survival rate in patients with single therapy (red line) was significantly lower than that in patients with combined therapy (green line). (C) Overall survival rate in patients with positive LMP1 expression (red line) was significantly lower than that in patients with negative LMP1 expression (green line). (D) Overall survival rate in patients with positive LMP2A expression (red line) was significantly lower than that in patients with negative LMP2A expression (green line).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539909&req=5

Figure 2: Analysis of the survival of ENKTL patients by Kaplan-Meier method. (A) Overall survival rate in patients with positive B symptoms (red line) was significantly lower than that in patients with negative B symptoms (green line). (B) Overall survival rate in patients with single therapy (red line) was significantly lower than that in patients with combined therapy (green line). (C) Overall survival rate in patients with positive LMP1 expression (red line) was significantly lower than that in patients with negative LMP1 expression (green line). (D) Overall survival rate in patients with positive LMP2A expression (red line) was significantly lower than that in patients with negative LMP2A expression (green line).
Mentions: Kaplan-Meier analysis of 16 ENKTL patients showed that the survival rate was significantly lower in patients with positive B symptoms, subjected to single therapy, or with high LMP1 and LMP2A expression. Log-rank test showed that positive B symptoms, treatment by single therapy, and high expression of LMP1 and LMP2A were associated with decreased overall survival of ENKTL patients (P = 0.0180, P = 0.0082, P = 0.0201, P = 0.0487) (Table 3, Figure 2).

Bottom Line: Latent membrane protein (LMP) 1 and LMP2A encoded by Epstein-Barr virus (EBV) are associated with the development of malignancies, but their expression in extranodal NK/T-cell lymphoma, nasal type (ENKTL) and the relationship with clinical characteristics of this disease remain poorly understood.High LMP1 expression was associated with positive B symptoms (p = 0.012), while high LMP2A expression was related to gender (p = 0.029).The expression of both LMP1 and LMP2A showed significant correlations with patients' overall survival (p = 0.049, p = 0.036).

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Nanjing Medical University, No,121 Jiang jia yuan, Nanjing 210011, China.

ABSTRACT

Background: Latent membrane protein (LMP) 1 and LMP2A encoded by Epstein-Barr virus (EBV) are associated with the development of malignancies, but their expression in extranodal NK/T-cell lymphoma, nasal type (ENKTL) and the relationship with clinical characteristics of this disease remain poorly understood. In the present study, we examined the expression of LMP1 and LMP2A in ENKTL, and investigated the correlations between LMP1 and LMP2A expression with clinicopathological characteristics of ENKTL patients.

Methods: Paraffin sections of surgically removed samples from 16 ENKTL patients were analyzed by immunohistochemistry and the related clinicopathological data were collected and analyzed.

Results: Elevated expression (immunohistochemistry score ≥ 4) of LMP1 and LMP2A was detected in the tumor cells of ENKTL. High LMP1 expression was associated with positive B symptoms (p = 0.012), while high LMP2A expression was related to gender (p = 0.029). The expression of both LMP1 and LMP2A showed significant correlations with patients' overall survival (p = 0.049, p = 0.036).

Conclusion: LMP1 and LMP2A may be prognostic indicators of survival in patients with ENKTL.

Virtual slides: http://www.diagnosticpathology.diagnomx.eu/vs/2443352538545899.

Show MeSH
Related in: MedlinePlus