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Immunological aspects predicting metastatic sentinel lymph node in early breast cancer patients.

Bordea C, Bordea M, Totan A, Condrea I, Voinea S, Sandru A, Plesca M, Blidaru A - J Med Life (2012)

Bottom Line: As a result, their recognition and elimination by the immune system is very difficult.The results were correlated with tumour size, presence of positive sentinel lymph node, tumour proliferation and growth markers (Ki-67, c-erbB2, bcl-2).Even in its less advanced stages, breast cancer is more aggressive and associates with an increased rate of sentinel lymph node metastases in patients below 50 years old, the tumour size exceeds 20 mm, with the presence of peritumoral lymphocytic infiltrate, positive Ki-67 and bcl-2, an alteration of T helper (Th) lymphocytes function, increased immune suppression through IL-2 decrease, signalled by blastic transformation indexes modifications and a drop in IL-2 production (p<0.01).

View Article: PubMed Central - PubMed

Affiliation: Surgical Oncology Department, Prof. Dr. Al. Trestioreanu Institute of Oncology, Bucharest. drbordea@yahoo.com

ABSTRACT
Tumour antigens are poorly expressed, heterogeneous and they modulate rapidly. As a result, their recognition and elimination by the immune system is very difficult. There are several mechanisms, by means of which, the host can neutralize oncogenesis and prevent it from occurring. The sentinel lymph node concept has brought about a revolution in the surgical treatment of the regional lymphatic basin while preserving the prognostic value of the regional lymph node status in breast cancer. This prospective study included 93 women with early breast cancer with initial indication for surgery in whom the sentinel lymph node technique was employed. Cell immune response was assessed prior to surgery by means of in vitro mononuclear cells blastic transformation assay (BLT), of immunoglobulin (Ig) and interleukin 2 (IL-2) measurements. The results were correlated with tumour size, presence of positive sentinel lymph node, tumour proliferation and growth markers (Ki-67, c-erbB2, bcl-2). Even in its less advanced stages, breast cancer is more aggressive and associates with an increased rate of sentinel lymph node metastases in patients below 50 years old, the tumour size exceeds 20 mm, with the presence of peritumoral lymphocytic infiltrate, positive Ki-67 and bcl-2, an alteration of T helper (Th) lymphocytes function, increased immune suppression through IL-2 decrease, signalled by blastic transformation indexes modifications and a drop in IL-2 production (p<0.01).

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Cellular immune response according to tumour immunohistochemistry
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Figure 3: Cellular immune response according to tumour immunohistochemistry

Mentions: Cellular immune response depending on tumour immunohistochemical markersImmune response was not influenced by the expression of tumour markers Ki-67 and c-erb B2. We identified a statistically significant reverse correlation with protein bcl 2 expression at a mitochondrial level (p<0.02). This may be due to the diminished apoptotic activity of tumour cells that express bcl 2 protein in a lower percentage (Fig. 3).


Immunological aspects predicting metastatic sentinel lymph node in early breast cancer patients.

Bordea C, Bordea M, Totan A, Condrea I, Voinea S, Sandru A, Plesca M, Blidaru A - J Med Life (2012)

Cellular immune response according to tumour immunohistochemistry
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539851&req=5

Figure 3: Cellular immune response according to tumour immunohistochemistry
Mentions: Cellular immune response depending on tumour immunohistochemical markersImmune response was not influenced by the expression of tumour markers Ki-67 and c-erb B2. We identified a statistically significant reverse correlation with protein bcl 2 expression at a mitochondrial level (p<0.02). This may be due to the diminished apoptotic activity of tumour cells that express bcl 2 protein in a lower percentage (Fig. 3).

Bottom Line: As a result, their recognition and elimination by the immune system is very difficult.The results were correlated with tumour size, presence of positive sentinel lymph node, tumour proliferation and growth markers (Ki-67, c-erbB2, bcl-2).Even in its less advanced stages, breast cancer is more aggressive and associates with an increased rate of sentinel lymph node metastases in patients below 50 years old, the tumour size exceeds 20 mm, with the presence of peritumoral lymphocytic infiltrate, positive Ki-67 and bcl-2, an alteration of T helper (Th) lymphocytes function, increased immune suppression through IL-2 decrease, signalled by blastic transformation indexes modifications and a drop in IL-2 production (p<0.01).

View Article: PubMed Central - PubMed

Affiliation: Surgical Oncology Department, Prof. Dr. Al. Trestioreanu Institute of Oncology, Bucharest. drbordea@yahoo.com

ABSTRACT
Tumour antigens are poorly expressed, heterogeneous and they modulate rapidly. As a result, their recognition and elimination by the immune system is very difficult. There are several mechanisms, by means of which, the host can neutralize oncogenesis and prevent it from occurring. The sentinel lymph node concept has brought about a revolution in the surgical treatment of the regional lymphatic basin while preserving the prognostic value of the regional lymph node status in breast cancer. This prospective study included 93 women with early breast cancer with initial indication for surgery in whom the sentinel lymph node technique was employed. Cell immune response was assessed prior to surgery by means of in vitro mononuclear cells blastic transformation assay (BLT), of immunoglobulin (Ig) and interleukin 2 (IL-2) measurements. The results were correlated with tumour size, presence of positive sentinel lymph node, tumour proliferation and growth markers (Ki-67, c-erbB2, bcl-2). Even in its less advanced stages, breast cancer is more aggressive and associates with an increased rate of sentinel lymph node metastases in patients below 50 years old, the tumour size exceeds 20 mm, with the presence of peritumoral lymphocytic infiltrate, positive Ki-67 and bcl-2, an alteration of T helper (Th) lymphocytes function, increased immune suppression through IL-2 decrease, signalled by blastic transformation indexes modifications and a drop in IL-2 production (p<0.01).

Show MeSH
Related in: MedlinePlus