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Immunological aspects predicting metastatic sentinel lymph node in early breast cancer patients.

Bordea C, Bordea M, Totan A, Condrea I, Voinea S, Sandru A, Plesca M, Blidaru A - J Med Life (2012)

Bottom Line: As a result, their recognition and elimination by the immune system is very difficult.The results were correlated with tumour size, presence of positive sentinel lymph node, tumour proliferation and growth markers (Ki-67, c-erbB2, bcl-2).Even in its less advanced stages, breast cancer is more aggressive and associates with an increased rate of sentinel lymph node metastases in patients below 50 years old, the tumour size exceeds 20 mm, with the presence of peritumoral lymphocytic infiltrate, positive Ki-67 and bcl-2, an alteration of T helper (Th) lymphocytes function, increased immune suppression through IL-2 decrease, signalled by blastic transformation indexes modifications and a drop in IL-2 production (p<0.01).

View Article: PubMed Central - PubMed

Affiliation: Surgical Oncology Department, Prof. Dr. Al. Trestioreanu Institute of Oncology, Bucharest. drbordea@yahoo.com

ABSTRACT
Tumour antigens are poorly expressed, heterogeneous and they modulate rapidly. As a result, their recognition and elimination by the immune system is very difficult. There are several mechanisms, by means of which, the host can neutralize oncogenesis and prevent it from occurring. The sentinel lymph node concept has brought about a revolution in the surgical treatment of the regional lymphatic basin while preserving the prognostic value of the regional lymph node status in breast cancer. This prospective study included 93 women with early breast cancer with initial indication for surgery in whom the sentinel lymph node technique was employed. Cell immune response was assessed prior to surgery by means of in vitro mononuclear cells blastic transformation assay (BLT), of immunoglobulin (Ig) and interleukin 2 (IL-2) measurements. The results were correlated with tumour size, presence of positive sentinel lymph node, tumour proliferation and growth markers (Ki-67, c-erbB2, bcl-2). Even in its less advanced stages, breast cancer is more aggressive and associates with an increased rate of sentinel lymph node metastases in patients below 50 years old, the tumour size exceeds 20 mm, with the presence of peritumoral lymphocytic infiltrate, positive Ki-67 and bcl-2, an alteration of T helper (Th) lymphocytes function, increased immune suppression through IL-2 decrease, signalled by blastic transformation indexes modifications and a drop in IL-2 production (p<0.01).

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Correlation between peritumoral lymphocyte infiltration and sentinel node status
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Figure 1: Correlation between peritumoral lymphocyte infiltration and sentinel node status

Mentions: A number of 22 tumours, where peritumoral lymphocytic infiltration was present, associated the presence of the neoplastic invasion in the sentinel lymph node (p<0.01). In 48 cases, where peritumoral lymphocytic infiltration was absent, the sentinel lymph node was free from disease (Fig. 1).


Immunological aspects predicting metastatic sentinel lymph node in early breast cancer patients.

Bordea C, Bordea M, Totan A, Condrea I, Voinea S, Sandru A, Plesca M, Blidaru A - J Med Life (2012)

Correlation between peritumoral lymphocyte infiltration and sentinel node status
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539851&req=5

Figure 1: Correlation between peritumoral lymphocyte infiltration and sentinel node status
Mentions: A number of 22 tumours, where peritumoral lymphocytic infiltration was present, associated the presence of the neoplastic invasion in the sentinel lymph node (p<0.01). In 48 cases, where peritumoral lymphocytic infiltration was absent, the sentinel lymph node was free from disease (Fig. 1).

Bottom Line: As a result, their recognition and elimination by the immune system is very difficult.The results were correlated with tumour size, presence of positive sentinel lymph node, tumour proliferation and growth markers (Ki-67, c-erbB2, bcl-2).Even in its less advanced stages, breast cancer is more aggressive and associates with an increased rate of sentinel lymph node metastases in patients below 50 years old, the tumour size exceeds 20 mm, with the presence of peritumoral lymphocytic infiltrate, positive Ki-67 and bcl-2, an alteration of T helper (Th) lymphocytes function, increased immune suppression through IL-2 decrease, signalled by blastic transformation indexes modifications and a drop in IL-2 production (p<0.01).

View Article: PubMed Central - PubMed

Affiliation: Surgical Oncology Department, Prof. Dr. Al. Trestioreanu Institute of Oncology, Bucharest. drbordea@yahoo.com

ABSTRACT
Tumour antigens are poorly expressed, heterogeneous and they modulate rapidly. As a result, their recognition and elimination by the immune system is very difficult. There are several mechanisms, by means of which, the host can neutralize oncogenesis and prevent it from occurring. The sentinel lymph node concept has brought about a revolution in the surgical treatment of the regional lymphatic basin while preserving the prognostic value of the regional lymph node status in breast cancer. This prospective study included 93 women with early breast cancer with initial indication for surgery in whom the sentinel lymph node technique was employed. Cell immune response was assessed prior to surgery by means of in vitro mononuclear cells blastic transformation assay (BLT), of immunoglobulin (Ig) and interleukin 2 (IL-2) measurements. The results were correlated with tumour size, presence of positive sentinel lymph node, tumour proliferation and growth markers (Ki-67, c-erbB2, bcl-2). Even in its less advanced stages, breast cancer is more aggressive and associates with an increased rate of sentinel lymph node metastases in patients below 50 years old, the tumour size exceeds 20 mm, with the presence of peritumoral lymphocytic infiltrate, positive Ki-67 and bcl-2, an alteration of T helper (Th) lymphocytes function, increased immune suppression through IL-2 decrease, signalled by blastic transformation indexes modifications and a drop in IL-2 production (p<0.01).

Show MeSH
Related in: MedlinePlus