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Magnetic resonance spectroscopy--a non-invasive method in evaluating focal and diffuse central nervous system disease.

Scheau C, Preda EM, Popa GA, Ghergus AE, Capsa RA, Lupescu IG - J Med Life (2012)

Bottom Line: Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain.Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy.This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Medical Imaging, Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. cristianscheau@gmail.com

ABSTRACT
Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain. Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy. This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

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Related in: MedlinePlus

Short TE spectrum of a low grade tumor (glioma). Note the elevation of Cho and decrease of NAA. No lipids or Lac increase (absence of necrosis). Voxel placement in three-dimensional planes (T2*, Flair and T2 respectively).
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Figure 3: Short TE spectrum of a low grade tumor (glioma). Note the elevation of Cho and decrease of NAA. No lipids or Lac increase (absence of necrosis). Voxel placement in three-dimensional planes (T2*, Flair and T2 respectively).

Mentions: Focal anomalies. Cerebral masses may be assessed through MRS, as it can provide information useful in the positive and differential diagnosis. It is intuitive that the voxel is placed on the lesion, but difficulties may occur when there is an inhomogeneity of structure, for necrotic and cystic areas, hemorrhage, calcifications, as well as edema should be avoided. In most cases, the voxel should encompass as much of the tissular mass as possible, in the most representative area, to get the most relevant spectrum and, in effect, the maximum diagnostic information. Acquisitions can also be performed after intravenous contrast administration, allowing a better differentiation of the tumoral area from the adjacent structures. Typical MRS anomalies in brain tumors include a decrease in NAA, and an increase in Cho (due to cellular proliferation), and lipids and lactate (in necrotic regions) (Fig. 3). Furthermore, a series of cerebral masses have distinct features, such as a mI increase in low-grade glioma [19], alanine increase in meningioma [20], or free amino acids in pyogenic abscesses [21].


Magnetic resonance spectroscopy--a non-invasive method in evaluating focal and diffuse central nervous system disease.

Scheau C, Preda EM, Popa GA, Ghergus AE, Capsa RA, Lupescu IG - J Med Life (2012)

Short TE spectrum of a low grade tumor (glioma). Note the elevation of Cho and decrease of NAA. No lipids or Lac increase (absence of necrosis). Voxel placement in three-dimensional planes (T2*, Flair and T2 respectively).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539838&req=5

Figure 3: Short TE spectrum of a low grade tumor (glioma). Note the elevation of Cho and decrease of NAA. No lipids or Lac increase (absence of necrosis). Voxel placement in three-dimensional planes (T2*, Flair and T2 respectively).
Mentions: Focal anomalies. Cerebral masses may be assessed through MRS, as it can provide information useful in the positive and differential diagnosis. It is intuitive that the voxel is placed on the lesion, but difficulties may occur when there is an inhomogeneity of structure, for necrotic and cystic areas, hemorrhage, calcifications, as well as edema should be avoided. In most cases, the voxel should encompass as much of the tissular mass as possible, in the most representative area, to get the most relevant spectrum and, in effect, the maximum diagnostic information. Acquisitions can also be performed after intravenous contrast administration, allowing a better differentiation of the tumoral area from the adjacent structures. Typical MRS anomalies in brain tumors include a decrease in NAA, and an increase in Cho (due to cellular proliferation), and lipids and lactate (in necrotic regions) (Fig. 3). Furthermore, a series of cerebral masses have distinct features, such as a mI increase in low-grade glioma [19], alanine increase in meningioma [20], or free amino acids in pyogenic abscesses [21].

Bottom Line: Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain.Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy.This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Medical Imaging, Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. cristianscheau@gmail.com

ABSTRACT
Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain. Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy. This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

Show MeSH
Related in: MedlinePlus