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Magnetic resonance spectroscopy--a non-invasive method in evaluating focal and diffuse central nervous system disease.

Scheau C, Preda EM, Popa GA, Ghergus AE, Capsa RA, Lupescu IG - J Med Life (2012)

Bottom Line: Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain.Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy.This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Medical Imaging, Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. cristianscheau@gmail.com

ABSTRACT
Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain. Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy. This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

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Related in: MedlinePlus

Short TE acquisition (TE=30ms) in a normal patient showing the same NAA, Cr, Cr2 and Cho peaks, and additional mI and Glx peaks, in normal ranges.
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Figure 2: Short TE acquisition (TE=30ms) in a normal patient showing the same NAA, Cr, Cr2 and Cho peaks, and additional mI and Glx peaks, in normal ranges.

Mentions: ∘ Short TE acquisitions (<40 ms) display a wider spectrum, in addition to the previously named molecules, one can also find myo-inositol (mI), the complex formed by glutamine, glutamate and GABA (Glx), as well as free lipids, in pathological conditions. The downfall is that certain resonances overlap, posing an inconvenient in the interpretation. This can be partly resolved in high field acquisitions that increase the resolution if the field homogeneity is respected [5] (Fig. 2).


Magnetic resonance spectroscopy--a non-invasive method in evaluating focal and diffuse central nervous system disease.

Scheau C, Preda EM, Popa GA, Ghergus AE, Capsa RA, Lupescu IG - J Med Life (2012)

Short TE acquisition (TE=30ms) in a normal patient showing the same NAA, Cr, Cr2 and Cho peaks, and additional mI and Glx peaks, in normal ranges.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539838&req=5

Figure 2: Short TE acquisition (TE=30ms) in a normal patient showing the same NAA, Cr, Cr2 and Cho peaks, and additional mI and Glx peaks, in normal ranges.
Mentions: ∘ Short TE acquisitions (<40 ms) display a wider spectrum, in addition to the previously named molecules, one can also find myo-inositol (mI), the complex formed by glutamine, glutamate and GABA (Glx), as well as free lipids, in pathological conditions. The downfall is that certain resonances overlap, posing an inconvenient in the interpretation. This can be partly resolved in high field acquisitions that increase the resolution if the field homogeneity is respected [5] (Fig. 2).

Bottom Line: Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain.Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy.This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Medical Imaging, Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. cristianscheau@gmail.com

ABSTRACT
Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain. Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy. This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

Show MeSH
Related in: MedlinePlus