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Magnetic resonance spectroscopy--a non-invasive method in evaluating focal and diffuse central nervous system disease.

Scheau C, Preda EM, Popa GA, Ghergus AE, Capsa RA, Lupescu IG - J Med Life (2012)

Bottom Line: Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain.Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy.This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Medical Imaging, Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. cristianscheau@gmail.com

ABSTRACT
Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain. Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy. This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

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Related in: MedlinePlus

Intermediate TE acquisition (TE=135ms) in a normal patient showing prominent NAA, Cr and Cho peaks. Also, a second Cr peak at ~ 4 ppm.
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Figure 1: Intermediate TE acquisition (TE=135ms) in a normal patient showing prominent NAA, Cr and Cho peaks. Also, a second Cr peak at ~ 4 ppm.

Mentions: ∘ Intermediate to long TE acquisitions (144-288 ms) imply the detection of a rather poor number of metabolites (mainly N-Acetyl Aspartate (NAA), creatine (Cr) and choline (Cho), and also lactate (Lac) in pathological conditions), but with a “cleaner” spectrum, without “noise” correspondent to other molecules (Fig. 1).


Magnetic resonance spectroscopy--a non-invasive method in evaluating focal and diffuse central nervous system disease.

Scheau C, Preda EM, Popa GA, Ghergus AE, Capsa RA, Lupescu IG - J Med Life (2012)

Intermediate TE acquisition (TE=135ms) in a normal patient showing prominent NAA, Cr and Cho peaks. Also, a second Cr peak at ~ 4 ppm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539838&req=5

Figure 1: Intermediate TE acquisition (TE=135ms) in a normal patient showing prominent NAA, Cr and Cho peaks. Also, a second Cr peak at ~ 4 ppm.
Mentions: ∘ Intermediate to long TE acquisitions (144-288 ms) imply the detection of a rather poor number of metabolites (mainly N-Acetyl Aspartate (NAA), creatine (Cr) and choline (Cho), and also lactate (Lac) in pathological conditions), but with a “cleaner” spectrum, without “noise” correspondent to other molecules (Fig. 1).

Bottom Line: Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain.Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy.This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology and Medical Imaging, Fundeni Clinical Institute, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. cristianscheau@gmail.com

ABSTRACT
Magnetic Resonance Spectroscopy is a non-invasive method, which can be performed following a routine Magnetic Resonance investigation within the same examination, and can provide very useful molecular information related to the metabolism and function of the normal and pathological structures of the brain. Its role is increasing in the establishment of a clear diagnosis, in both focal and diffuse central nervous system diseases, and the tendency is to replace the histopathology test, in certain cases, with similar or sometimes better diagnostic accuracy. This paper summarizes the principle, method, and main clinical applications, standing as a guide to procedure performing and results interpretation.

Show MeSH
Related in: MedlinePlus