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Anxiolytic effects of flavonoids in animal models of posttraumatic stress disorder.

Zhang LM, Yao JZ, Li Y, Li K, Chen HX, Zhang YZ, Li YF - Evid Based Complement Alternat Med (2012)

Bottom Line: To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD.However, SSRIs largely have several disadvantages which limit their utility.Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models.

View Article: PubMed Central - PubMed

Affiliation: Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

ABSTRACT
The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of PTSD. To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD. However, SSRIs largely have several disadvantages which limit their utility. Our previous study has also shown that administration of the total flavonoids, isolated from the extract of Xiaobuxin-Tang (XBXT, mild mind-easing decoction), comprising four Chinese medicines including Haematitum, Flos Inulae, Folium Phyllostachydis Henonis, and Semen Sojae Preparatum, exerted significant antidepressant-like effect in chronically mildly stressed rats, possibly mediated by serotonergic activation. Since the central serotonergic dysfunction is an important and well-known cause mediating the pathophysiology of trauma-related symptoms in PTSD, it is reasonable to predict that flavonoids may exert therapeutic effects on PTSD in animal models. Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models. Ser, an SSRI, was administered as a positive control. Furthermore, the changes of brain monoaminergic neurotransmitters after chronic flavonoids administration have also been assessed in SPS-treated rats.

No MeSH data available.


Related in: MedlinePlus

The effects of repeated treatment with Ser or flavonoids on locomotor activity in SPS-exposed rats. On day 13 after SPS procedure, the distance (a) and ambulatory time (b) were measured. Daily administration of Ser or flavonoids was started from the first day after the SPS procedure. Each column represents the means ± SEM (n = 10).
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fig3: The effects of repeated treatment with Ser or flavonoids on locomotor activity in SPS-exposed rats. On day 13 after SPS procedure, the distance (a) and ambulatory time (b) were measured. Daily administration of Ser or flavonoids was started from the first day after the SPS procedure. Each column represents the means ± SEM (n = 10).

Mentions: To examine the possibility that SPS and/or drug treatments influenced the baseline locomotor activity in “fear-conditioned” rats (subjected to fear conditioning 24 h before the measurement), we investigated the level of spontaneous locomotor activity for each group. The results showed that there was no significant difference between groups, indicating that neither SPS nor chronic drug treatments affected the spontaneous activity of rats (Figures 3(a) and 3(b)).


Anxiolytic effects of flavonoids in animal models of posttraumatic stress disorder.

Zhang LM, Yao JZ, Li Y, Li K, Chen HX, Zhang YZ, Li YF - Evid Based Complement Alternat Med (2012)

The effects of repeated treatment with Ser or flavonoids on locomotor activity in SPS-exposed rats. On day 13 after SPS procedure, the distance (a) and ambulatory time (b) were measured. Daily administration of Ser or flavonoids was started from the first day after the SPS procedure. Each column represents the means ± SEM (n = 10).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539772&req=5

fig3: The effects of repeated treatment with Ser or flavonoids on locomotor activity in SPS-exposed rats. On day 13 after SPS procedure, the distance (a) and ambulatory time (b) were measured. Daily administration of Ser or flavonoids was started from the first day after the SPS procedure. Each column represents the means ± SEM (n = 10).
Mentions: To examine the possibility that SPS and/or drug treatments influenced the baseline locomotor activity in “fear-conditioned” rats (subjected to fear conditioning 24 h before the measurement), we investigated the level of spontaneous locomotor activity for each group. The results showed that there was no significant difference between groups, indicating that neither SPS nor chronic drug treatments affected the spontaneous activity of rats (Figures 3(a) and 3(b)).

Bottom Line: To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD.However, SSRIs largely have several disadvantages which limit their utility.Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models.

View Article: PubMed Central - PubMed

Affiliation: Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

ABSTRACT
The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of PTSD. To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD. However, SSRIs largely have several disadvantages which limit their utility. Our previous study has also shown that administration of the total flavonoids, isolated from the extract of Xiaobuxin-Tang (XBXT, mild mind-easing decoction), comprising four Chinese medicines including Haematitum, Flos Inulae, Folium Phyllostachydis Henonis, and Semen Sojae Preparatum, exerted significant antidepressant-like effect in chronically mildly stressed rats, possibly mediated by serotonergic activation. Since the central serotonergic dysfunction is an important and well-known cause mediating the pathophysiology of trauma-related symptoms in PTSD, it is reasonable to predict that flavonoids may exert therapeutic effects on PTSD in animal models. Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models. Ser, an SSRI, was administered as a positive control. Furthermore, the changes of brain monoaminergic neurotransmitters after chronic flavonoids administration have also been assessed in SPS-treated rats.

No MeSH data available.


Related in: MedlinePlus