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Anxiolytic effects of flavonoids in animal models of posttraumatic stress disorder.

Zhang LM, Yao JZ, Li Y, Li K, Chen HX, Zhang YZ, Li YF - Evid Based Complement Alternat Med (2012)

Bottom Line: To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD.However, SSRIs largely have several disadvantages which limit their utility.Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models.

View Article: PubMed Central - PubMed

Affiliation: Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

ABSTRACT
The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of PTSD. To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD. However, SSRIs largely have several disadvantages which limit their utility. Our previous study has also shown that administration of the total flavonoids, isolated from the extract of Xiaobuxin-Tang (XBXT, mild mind-easing decoction), comprising four Chinese medicines including Haematitum, Flos Inulae, Folium Phyllostachydis Henonis, and Semen Sojae Preparatum, exerted significant antidepressant-like effect in chronically mildly stressed rats, possibly mediated by serotonergic activation. Since the central serotonergic dysfunction is an important and well-known cause mediating the pathophysiology of trauma-related symptoms in PTSD, it is reasonable to predict that flavonoids may exert therapeutic effects on PTSD in animal models. Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models. Ser, an SSRI, was administered as a positive control. Furthermore, the changes of brain monoaminergic neurotransmitters after chronic flavonoids administration have also been assessed in SPS-treated rats.

No MeSH data available.


Related in: MedlinePlus

The effects of repeated treatment with Ser or flavonoids on freezing behavior in mice after exposure to electric foot-shocks. The total cumulative freezing time was determined on day 3, 8, and 15. Daily administrations of Ser or flavonoids were started from the first day of training session. Data are presented as mean ± SEM (n = 10). *P < 0.05, **P < 0.01 compared with foot shock (−) group; #P < 0.05, ##P < 0.01 compared with saline-treated foot shock (+) group (ANOVA followed by Dunnett's t-test).
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Related In: Results  -  Collection


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fig1: The effects of repeated treatment with Ser or flavonoids on freezing behavior in mice after exposure to electric foot-shocks. The total cumulative freezing time was determined on day 3, 8, and 15. Daily administrations of Ser or flavonoids were started from the first day of training session. Data are presented as mean ± SEM (n = 10). *P < 0.05, **P < 0.01 compared with foot shock (−) group; #P < 0.05, ##P < 0.01 compared with saline-treated foot shock (+) group (ANOVA followed by Dunnett's t-test).

Mentions: Exposure to foot shock significantly increased the contextual freezing response (day 3: F[5, 54] = 6.833, P < 0.01; day 8: F[5, 54] = 3.222, P < 0.05; and day 15: F[5, 54] = 4.303, P < 0.01). Repeated treatment with Ser for 15 days significantly reduced the freezing behavior (P < 0.01) induced by foot shock. A similar effect was also observed after repeated administration of flavonoids at doses of 25 and 50 mg/kg (P < 0.05 and P < 0.01 resp.; Figure 1).


Anxiolytic effects of flavonoids in animal models of posttraumatic stress disorder.

Zhang LM, Yao JZ, Li Y, Li K, Chen HX, Zhang YZ, Li YF - Evid Based Complement Alternat Med (2012)

The effects of repeated treatment with Ser or flavonoids on freezing behavior in mice after exposure to electric foot-shocks. The total cumulative freezing time was determined on day 3, 8, and 15. Daily administrations of Ser or flavonoids were started from the first day of training session. Data are presented as mean ± SEM (n = 10). *P < 0.05, **P < 0.01 compared with foot shock (−) group; #P < 0.05, ##P < 0.01 compared with saline-treated foot shock (+) group (ANOVA followed by Dunnett's t-test).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3539772&req=5

fig1: The effects of repeated treatment with Ser or flavonoids on freezing behavior in mice after exposure to electric foot-shocks. The total cumulative freezing time was determined on day 3, 8, and 15. Daily administrations of Ser or flavonoids were started from the first day of training session. Data are presented as mean ± SEM (n = 10). *P < 0.05, **P < 0.01 compared with foot shock (−) group; #P < 0.05, ##P < 0.01 compared with saline-treated foot shock (+) group (ANOVA followed by Dunnett's t-test).
Mentions: Exposure to foot shock significantly increased the contextual freezing response (day 3: F[5, 54] = 6.833, P < 0.01; day 8: F[5, 54] = 3.222, P < 0.05; and day 15: F[5, 54] = 4.303, P < 0.01). Repeated treatment with Ser for 15 days significantly reduced the freezing behavior (P < 0.01) induced by foot shock. A similar effect was also observed after repeated administration of flavonoids at doses of 25 and 50 mg/kg (P < 0.05 and P < 0.01 resp.; Figure 1).

Bottom Line: To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD.However, SSRIs largely have several disadvantages which limit their utility.Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models.

View Article: PubMed Central - PubMed

Affiliation: Department of New Drug Evaluation, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

ABSTRACT
The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of PTSD. To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD. However, SSRIs largely have several disadvantages which limit their utility. Our previous study has also shown that administration of the total flavonoids, isolated from the extract of Xiaobuxin-Tang (XBXT, mild mind-easing decoction), comprising four Chinese medicines including Haematitum, Flos Inulae, Folium Phyllostachydis Henonis, and Semen Sojae Preparatum, exerted significant antidepressant-like effect in chronically mildly stressed rats, possibly mediated by serotonergic activation. Since the central serotonergic dysfunction is an important and well-known cause mediating the pathophysiology of trauma-related symptoms in PTSD, it is reasonable to predict that flavonoids may exert therapeutic effects on PTSD in animal models. Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models. Ser, an SSRI, was administered as a positive control. Furthermore, the changes of brain monoaminergic neurotransmitters after chronic flavonoids administration have also been assessed in SPS-treated rats.

No MeSH data available.


Related in: MedlinePlus