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Characteristic patterns of microRNA expression in human bladder cancer.

Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA - Front Genet (2013)

Bottom Line: We performed a systematic analysis of scientific reports that link differences in miRNA expression with the pathogenesis of bladder cancer (BC).Among the 95 differentially expressed miRNAs that we identified from the literature, we classify 48 as up-regulated in BC, 35 as down-regulated, and 12 as contradictory (contradictory data were reported in one or more studies on the gene).In addition, we discuss the possible roles of differentially expressed miRNAs in the regulation of intracellular signaling pathways in BC.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Bioinformatics, Dima RogachevFederal Research Center of Pediatric Hematology, Oncology and Immunology Moscow, Russia ; Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Moscow, Russia.

ABSTRACT
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene expression. Their altered expression and functional activity have been observed in many human cancers. miRNAs represent promising diagnostic and prognostic molecular biomarkers, and also serve as novel therapeutic targets. We performed a systematic analysis of scientific reports that link differences in miRNA expression with the pathogenesis of bladder cancer (BC). This literature review is the first comprehensive database of miRNA molecules with biased expression profiles in BC. Among the 95 differentially expressed miRNAs that we identified from the literature, we classify 48 as up-regulated in BC, 35 as down-regulated, and 12 as contradictory (contradictory data were reported in one or more studies on the gene). In addition, we discuss the possible roles of differentially expressed miRNAs in the regulation of intracellular signaling pathways in BC.

No MeSH data available.


Related in: MedlinePlus

Bladder cancer miRNA biomarker representation according to published data.
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Figure 2: Bladder cancer miRNA biomarker representation according to published data.

Mentions: In addition, six miRNA genes were reported to be hypermethylated in BC, while only one gene was reported as undermethylated in BC (Figure 2). Of these, expression data in BC is available for only one miRNA molecule (miR34). We summarized this data in a publically available database (http://bladder.pparser.net/MIRMarkers.php), which includes miRNA names, their roles in BC, and primary literature studies with supporting expression data.


Characteristic patterns of microRNA expression in human bladder cancer.

Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA - Front Genet (2013)

Bladder cancer miRNA biomarker representation according to published data.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539722&req=5

Figure 2: Bladder cancer miRNA biomarker representation according to published data.
Mentions: In addition, six miRNA genes were reported to be hypermethylated in BC, while only one gene was reported as undermethylated in BC (Figure 2). Of these, expression data in BC is available for only one miRNA molecule (miR34). We summarized this data in a publically available database (http://bladder.pparser.net/MIRMarkers.php), which includes miRNA names, their roles in BC, and primary literature studies with supporting expression data.

Bottom Line: We performed a systematic analysis of scientific reports that link differences in miRNA expression with the pathogenesis of bladder cancer (BC).Among the 95 differentially expressed miRNAs that we identified from the literature, we classify 48 as up-regulated in BC, 35 as down-regulated, and 12 as contradictory (contradictory data were reported in one or more studies on the gene).In addition, we discuss the possible roles of differentially expressed miRNAs in the regulation of intracellular signaling pathways in BC.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Bioinformatics, Dima RogachevFederal Research Center of Pediatric Hematology, Oncology and Immunology Moscow, Russia ; Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Moscow, Russia.

ABSTRACT
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene expression. Their altered expression and functional activity have been observed in many human cancers. miRNAs represent promising diagnostic and prognostic molecular biomarkers, and also serve as novel therapeutic targets. We performed a systematic analysis of scientific reports that link differences in miRNA expression with the pathogenesis of bladder cancer (BC). This literature review is the first comprehensive database of miRNA molecules with biased expression profiles in BC. Among the 95 differentially expressed miRNAs that we identified from the literature, we classify 48 as up-regulated in BC, 35 as down-regulated, and 12 as contradictory (contradictory data were reported in one or more studies on the gene). In addition, we discuss the possible roles of differentially expressed miRNAs in the regulation of intracellular signaling pathways in BC.

No MeSH data available.


Related in: MedlinePlus