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Characteristic patterns of microRNA expression in human bladder cancer.

Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA - Front Genet (2013)

Bottom Line: We performed a systematic analysis of scientific reports that link differences in miRNA expression with the pathogenesis of bladder cancer (BC).Among the 95 differentially expressed miRNAs that we identified from the literature, we classify 48 as up-regulated in BC, 35 as down-regulated, and 12 as contradictory (contradictory data were reported in one or more studies on the gene).In addition, we discuss the possible roles of differentially expressed miRNAs in the regulation of intracellular signaling pathways in BC.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Bioinformatics, Dima RogachevFederal Research Center of Pediatric Hematology, Oncology and Immunology Moscow, Russia ; Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Moscow, Russia.

ABSTRACT
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene expression. Their altered expression and functional activity have been observed in many human cancers. miRNAs represent promising diagnostic and prognostic molecular biomarkers, and also serve as novel therapeutic targets. We performed a systematic analysis of scientific reports that link differences in miRNA expression with the pathogenesis of bladder cancer (BC). This literature review is the first comprehensive database of miRNA molecules with biased expression profiles in BC. Among the 95 differentially expressed miRNAs that we identified from the literature, we classify 48 as up-regulated in BC, 35 as down-regulated, and 12 as contradictory (contradictory data were reported in one or more studies on the gene). In addition, we discuss the possible roles of differentially expressed miRNAs in the regulation of intracellular signaling pathways in BC.

No MeSH data available.


Related in: MedlinePlus

The two-pathway model of different types of bladder cancer development, and the miRNAs that regulate these pathways. miRNAs that were reported to be down-regulated in BC are highlighted in red, and up-regulated miRNAs are highlighted in green. miRNA target genes are shown in blue in front of the respective miRNA names.
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Figure 1: The two-pathway model of different types of bladder cancer development, and the miRNAs that regulate these pathways. miRNAs that were reported to be down-regulated in BC are highlighted in red, and up-regulated miRNAs are highlighted in green. miRNA target genes are shown in blue in front of the respective miRNA names.

Mentions: Differentially expressed miRNAs may regulate intracellular signaling pathways. For example, it was demonstrated that this is the case for two signaling pathways associated with BC progression. Abnormal activation of the FGFR3 gene by means of either overexpression or mutation can be found in approximately 80% of non-invasive bladder tumors (Cappellen et al., 1999; Billerey et al., 2001). FGFR3 and several other growth factor receptors participate in the activation of the RAS kinase signaling pathway. Activation of this pathway leads to the increased cell proliferation, motility, and cancer transformation through hyperplasia of normal urothelium (Figure 1). Using bioinformatic methods, it was predicted that some miRNA molecules aberrantly expressed in BC actually target the FGFR3 gene product. Examples of this include miR-145, miR-101, miR-99a, and miR-100. Furthermore, the regulation of FGFR3 by miR-99a and miR-100 has been experimentally validated (Catto et al., 2009). Increased expression of miR-143 in BC cells is accompanied by lower expression of RAS genes. Another line of evidence recently confirmed this by showing that induced transcription of miR-143 in BC cell lines led to decreased expression of RAS (Lin et al., 2009; Kent et al., 2010). Another study demonstrates that low expression of miR-7 is associated with the hyperactive FGFR3 mutation status found in BC tissues (Veerla et al., 2009).


Characteristic patterns of microRNA expression in human bladder cancer.

Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA - Front Genet (2013)

The two-pathway model of different types of bladder cancer development, and the miRNAs that regulate these pathways. miRNAs that were reported to be down-regulated in BC are highlighted in red, and up-regulated miRNAs are highlighted in green. miRNA target genes are shown in blue in front of the respective miRNA names.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3539722&req=5

Figure 1: The two-pathway model of different types of bladder cancer development, and the miRNAs that regulate these pathways. miRNAs that were reported to be down-regulated in BC are highlighted in red, and up-regulated miRNAs are highlighted in green. miRNA target genes are shown in blue in front of the respective miRNA names.
Mentions: Differentially expressed miRNAs may regulate intracellular signaling pathways. For example, it was demonstrated that this is the case for two signaling pathways associated with BC progression. Abnormal activation of the FGFR3 gene by means of either overexpression or mutation can be found in approximately 80% of non-invasive bladder tumors (Cappellen et al., 1999; Billerey et al., 2001). FGFR3 and several other growth factor receptors participate in the activation of the RAS kinase signaling pathway. Activation of this pathway leads to the increased cell proliferation, motility, and cancer transformation through hyperplasia of normal urothelium (Figure 1). Using bioinformatic methods, it was predicted that some miRNA molecules aberrantly expressed in BC actually target the FGFR3 gene product. Examples of this include miR-145, miR-101, miR-99a, and miR-100. Furthermore, the regulation of FGFR3 by miR-99a and miR-100 has been experimentally validated (Catto et al., 2009). Increased expression of miR-143 in BC cells is accompanied by lower expression of RAS genes. Another line of evidence recently confirmed this by showing that induced transcription of miR-143 in BC cell lines led to decreased expression of RAS (Lin et al., 2009; Kent et al., 2010). Another study demonstrates that low expression of miR-7 is associated with the hyperactive FGFR3 mutation status found in BC tissues (Veerla et al., 2009).

Bottom Line: We performed a systematic analysis of scientific reports that link differences in miRNA expression with the pathogenesis of bladder cancer (BC).Among the 95 differentially expressed miRNAs that we identified from the literature, we classify 48 as up-regulated in BC, 35 as down-regulated, and 12 as contradictory (contradictory data were reported in one or more studies on the gene).In addition, we discuss the possible roles of differentially expressed miRNAs in the regulation of intracellular signaling pathways in BC.

View Article: PubMed Central - PubMed

Affiliation: Laboratory of Bioinformatics, Dima RogachevFederal Research Center of Pediatric Hematology, Oncology and Immunology Moscow, Russia ; Group for Genomic Regulation of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Moscow, Russia.

ABSTRACT
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene expression. Their altered expression and functional activity have been observed in many human cancers. miRNAs represent promising diagnostic and prognostic molecular biomarkers, and also serve as novel therapeutic targets. We performed a systematic analysis of scientific reports that link differences in miRNA expression with the pathogenesis of bladder cancer (BC). This literature review is the first comprehensive database of miRNA molecules with biased expression profiles in BC. Among the 95 differentially expressed miRNAs that we identified from the literature, we classify 48 as up-regulated in BC, 35 as down-regulated, and 12 as contradictory (contradictory data were reported in one or more studies on the gene). In addition, we discuss the possible roles of differentially expressed miRNAs in the regulation of intracellular signaling pathways in BC.

No MeSH data available.


Related in: MedlinePlus